Kajimura, Mayumi

J-GLOBAL         Last updated: Aug 24, 2019 at 02:56
 
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Name
Kajimura, Mayumi
Affiliation
Keio University
Section
School of Medicine
Job title
Professor
Degree
Doctor of Philosophy in Physiology(University of California, Davis (Davis, CA, USA))
ORCID ID
orcid.org/0000-0003-3773-6874

Profile

My research focuses on how various gaseous molecules such as molecular hydrogen (H2), molecular oxygen (O2), NO, H2S, CO2 and CO are sensed in our body. We are particularly interested in the interaction between gaseous molecules and their receptor proteins, gas-sensing proteins and how these gaseous molecules modulate vascular tone in various organs. While the NO signaling has been well-defined, the CO signaling requires further investigation with respect to identifying receptor molecules and their downstream effectors. Like NO, CO has an ability to bind to the ferrous heme of a variety of proteins with high affinity; thus, it is capable of either stimulating or inhibiting catalytic activities of heme proteins. Thus in current studies we are investigating the possibility that CO targets for proteins containing prosthetic heme and by altering their activity it controls the CNS function. We use both in vivo and in vitro systems in parallel to compensate inherent weakness of each model. This requires developing techniques which range from molecular biology, cell biology, protein biochemistry, and single vessel studies to whole animals.

Research Areas

 
 

Academic & Professional Experience

 
Nov 1995
 - 
Sep 1999
Postdoctoral Researcher (Wellcome trust fellow), Section of Cellular & Integrative Biology, Division of Biomedical Sciences, Imperial College School of Medicine, London, UK
 
Oct 1999
 - 
Nov 1999
Research Associate, Department of Biochemistry, Keio University School of Medicine
 
Dec 1999
 - 
Sep 2006
Instructor, Department of Biochemistry, Keio University School of Medicine
 
Oct 2006
 - 
Dec 2008
Instructor, Department of Biochemistry, Keio University School of Medicine
 
Jan 2009
 - 
Sep 2012
Assistant Professor, Department of Biochemistry, Keio University School of Medicine
 

Education

 
Oct 1990
 - 
Dec 1995
Physiology Graduate Group, Graduate School, School of Medicine, University of California Davis
 

Committee Memberships

 
Oct 2012
 - 
Mar 2016
慶應義塾大学医学部  学務委員会委員
 
Oct 2011
 - 
Sep 2015
慶應義塾大学医学部  自主学習委員会委員
 
Apr 2011
 - 
Sep 2015
慶應義塾大学  国際センター学生交換・在外研修委員会委員
 
Feb 2010
 - 
Today
日本微小循環学会  国際交流委員長
 
Apr 2009
 - 
Mar 2015
慶應義塾大学医学部  動物実験運営委員会委員
 

Awards & Honors

 
Apr 2004
August Krogh Young Investigator Award, Microcirculatory Society (USA)
 
Apr 2004
Selected for the 50th Anniversary Historical Poster, American Physiology Society/The Microcirculatory Society
 
Oct 1993
International Fellowship, American Association of University Women
 
Oct 1992
Regents Fellowship, University of California
 
Apr 1998
August Krogh Young Investigator Award, The Microcirculatory Society (USA)
 

Published Papers

 
M. Kajimura, R. Fukuda, R. M. Bateman, T. Yamamoto and M. Suematsu
Antioxid Redox Signal   13(2) 157-192   Jul 2010
K. Hattori, M. Kajimura, T. Hishiki, T. Nakanishi, A. Kubo, Y. Nagahata, M. Ohmura, A. Yachie-Kinoshita, T. Matsuura, T. Morikawa, T. Nakamura, M. Setou and M. Suematsu
Antioxid Redox Signal   13(8) 1157-1167   Oct 2010
T. Morikawa, M. Kajimura, T. Nakamura, T. Hishiki, T. Nakanishi, Y. Yukutake, Y. Nagahata, M. Ishikawa, K. Hattori, T. Takenouchi, T. Takahashi, I. Ishii, K. Matsubara, Y. Kabe, S. Uchiyama, E. Nagata, M. M. Gadalla, S. H. Snyder and M. Suematsu
Proc Natl Acad Sci U S A   109(4) 1293-1298   Jan 2012
S. Yamazoe, M. Naya, M. Shiota, T. Morikawa, A. Kubo, T. Tani, T. Hishiki, T. Horiuchi, M. Suematsu and M. Kajimura
ACS Nano   8(6) 5622-5632   Jun 2014
T. Takenouchi, Y. Sugiura, T. Morikawa, T. Nakanishi, Y. Nagahata, T. Sugioka, K. Honda, A. Kubo, T. Hishiki, T. Matsuura, T. Hoshino, T. Takahashi, M. Suematsu and M. Kajimura
J Cereb Blood Flow Metab   35(5) 794-805   May 2015

Conference Activities & Talks

 
Oxidative stress in no-mediated signaling in experimental diabetic retinopathy
Schaefer Silke, Kajimura Mayumi, Hanawa Toshihiko, Suematsu Makoto, Watanabe Kenji
World Congress of Internal Medicine   May 2002   
Oxidative stress in experimental diabetic retinopathy
Schaefer Silke, Kajimura Mayumi, Kashiba Misato, Watanabe Kenji, Uchida Kouji, Suematsu Makoto
第72回日本生化学学会大会 (2001)   Nov 2001   
脳微小循環調節機構における一酸化炭素の役割
Ishikawa Mami,Sekiduka Eiichi,Kajimura Mayumi,Yamaguchi Noriyuki,Terao Satoshi,Kawase Takeshi,Suematsu Makoto
第26回日本微小循環学会   Feb 2001   
Roles of endogenous carbon monoxide in regulation of soluble guanylate cyclase-mediated nitric oxide sensing for neural transmission in rat retina [Invited]
Kajimura Mayumi, Tsuyama Shingo, Ishimura Yuzuru, Suematsu Makoto
日本微小循環学会   Feb 2001   
NO,COによる可溶性グアニル酸シクラーゼ活性化の可視化
Suematsu Makoto,Kajimura Mayumi,Tsuyama Shingo,Ishimura Yuzuru
日本組織細胞化学会シンポジウム「活性酸素の視覚化」   Dec 2000   

Teaching Experience

 

Research Grants & Projects

 
Effects of molecular hydrogen on ischemic brain injury
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2019 - Mar 2022    Investigator(s): 梶村 眞弓
ガス分子依存性脳血流代謝カップリング機構の解明:代謝解剖学的アプローチを用いて
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2019    Investigator(s): 梶村 眞弓
JST戦略的創造研究推進事業 ERATO国際化活動支援
Japan Science and Technology Agency,: The Exploratory Research for Advanced Technology (ERATO)
Project Year: Jul 2015 - Today
公益財団法人鈴木謙三記念医科学応用研究財団 二国間学術交流集会開催助成
Project Year: Jun 2015 - Today
定量的質量イメージング技術とオミクス解析技術を用いたがんおよび感染症の包括的解明と医学応用
島津製作所: 委託研究費
Project Year: Apr 2015 - Mar 2017