Okita Hajime - My portal

Profile Information

Affiliation: Associate Professor, School of Medicine Division of Diagnostic Pathology, Keio University

Degree: 博士（医学）(慶應義塾大学)

J-GLOBAL ID: 200901063375034042
researchmap Member ID: 1000314966

Research Interests

Research Areas

Life sciences / Human pathology /

Research History

Dec, 2014 - Present

Department of Pathology, Keio University School of Medicine
Apr, 2010 - Nov, 2014

National Center for Child Health and Development, Department of Pediatric Hematology and Oncology Research
May, 2003 - Mar, 2010

National Center for Child Health and Development, Department of Developmental Biology

Education

- 1999

Graduate School of Medicine, Keio University

Papers

116

Integrated diagnosis based on transcriptome analysis in suspected pediatric sarcomas

Ichikawa D, Yamashita K, Okuno Y, Muramatsu H, Murakami N, Suzuki K, Kojima D, Kataoka S, Hamada M, Taniguchi R …

npj Genomic Medicine, 6(1) 49-49, Dec, 2021
Frequent breakpoints of focal deletion and uniparental disomy in 22q11.1 or 11.2 segmental duplication region reveal distinct tumorigenesis in rhabdoid tumor of the kidney

Haruta M, Arai Y, Okita H, Tanaka Y, Takimoto T, Kamijo T, Oue T, Souzaki R, Taguchi T, Kuwahara Y …

Genes Chromosomes and Cancer, 60(8) 546-558, Aug, 2021
Clinical outcome of patients with recurrent or refractory localized Ewing's sarcoma family of tumors: A retrospective report from the Japan Ewing Sarcoma Study Group

Umeda K, Miyamura T, Yamada K, Sano H, Hosono A, Sumi M, Okita H, Kumamoto T, Kawai A, Hirayama J …

Cancer Reports, 4(3) e1329, Jun, 2021
Estimating copy number using next-generation sequencing to determine ERBB2 amplification status

Nakamura K, Aimono E, Oba J, Hayashi H, Tanishima S, Hayashida T, Chiyoda T, Kosaka T, Hishida T, Kawakubo H …

Medical Oncology, 38(4) 36-36, Apr, 2021
Prognostic and therapeutic factors influencing the clinical outcome of metastatic Ewing sarcoma family of tumors: A retrospective report from the Japan Ewing Sarcoma Study Group

Umeda K, Miyamura T, Yamada K, Sano H, Hosono A, Sumi M, Okita H, Kamio T, Maeda N, Fujisaki H …

Pediatric Blood and Cancer, 68(3) e28844, Mar, 2021
Dedifferentiated Osteosarcoma of the Distal Ulna: A Case Report

Tsujisaka R, Nakayama R, Sekita T, Asano N, Kikuta K, Oguro S, Takeuchi K, Sasaki A, Okita H, Nakamura M …

Case Reports in Oncology, 14(2) 1228-1236, 2021
A rare case of dumbbell-shaped lymphoplasmacyte-rich meningioma arising at the upper cervical spinal cord

Fukui K, Tsuji O, Suzuki S, Nori S, Nagoshi N, Okada E, Yagi M, Okita H, Fujita N, Watanabe K …

Journal of Orthopaedic Science, 28(6) 1439-1444, 2021
High prevalence of SMARCB1 constitutional abnormalities including mosaicism in malignant rhabdoid tumors

Shirai R, Osumi T, Terashima K, Kiyotani C, Uchiyama M, Tsujimoto S, Yoshida M, Yoshida K, Uchiyama T, Tomizawa D …

European Journal of Human Genetics, 28(8) 1124-1128, Aug 1, 2020 Peer-reviewed
Central nervous system ganglioneuroblastoma harboring MYO5A-NTRK3 fusion

Ito J, Nakano Y, Shima H, Miwa T, Kogure Y, Isshiki K, Yamazaki F, Oishi Y, Morimoto Y, Kataoka K …

Brain Tumor Pathology, 37(3) 105-110, Jul 1, 2020
Multimodal treatment including standard chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide for the Ewing sarcoma family of tumors in Japan: Results of the Japan Ewing Sarcoma Study 04

Chin M, Yokoyama R, Sumi M, Okita H, Kawai A, Hosono A, Koga Y, Sano H, Watanabe H, Ozaki T …

Pediatric Blood and Cancer, 67(5) e28194, May 1, 2020
Pseudomyogenic hemangioendothelioma of bone treated with denosumab: A case report

Otani S, Nakayama R, Sekita T, Hirozane T, Asano N, Nishimoto K, Sasaki A, Okita H, Morioka H, Nakamura M …

BMC Cancer, 19(1), Sep 3, 2019
Blastemal predominant type Wilms tumor in Japan: Japan Children's Cancer Group

Koshinaga T, Takimoto T, Okita H, Tanaka Y, Inoue E, Oue T, Nozaki M, Tsuchiya K, Haruta M, Kaneko Y …

Pediatrics International, 61(4) 351-357, Apr, 2019 Peer-reviewed
Classic-type epithelioid sarcoma arising from the sciatic nerve: A case report

Maeda K, Asano N, Kikuta K, Okita H, Nakamura M, Matsumoto M, Nakayama R

Journal of Orthopaedic Science, 2019
Combined Genetic and Chromosomal Characterization of Wilms Tumors Identifies Chromosome 12 Gain as a Potential New Marker Predicting a Favorable Outcome.

Masayuki Haruta, Yasuhito Arai, Hajime Okita, Yukichi Tanaka, Tetsuya Takimoto, Ryuichi P Sugino, Yasuhiro Yamada, Takehiko Kamijo, Takaharu Oue, Masahiro Fukuzawa …

Neoplasia (New York, N.Y.), 21(1) 117-131, Jan, 2019
A curative treatment strategy using tumor debulking surgery combined with immune checkpoint inhibitors for advanced pediatric solid tumors: An in vivo study using a murine model of osteosarcoma

Shimizu T, Fuchimoto Y, Okita H, Fukuda K, Kitagawa Y, Ueno S, Kuroda T

Journal of Pediatric Surgery, 53(12) 2460-2464, Dec, 2018
Preoperative diagnosis of clear cell sarcoma of the kidney by detection of BCOR internal tandem duplication in circulating tumor DNA.

Hitomi Ueno-Yokohata, Hajime Okita, Keiko Nakasato, Tomoro Hishiki, Ryota Shirai, Shinichi Tsujimoto, Tomoo Osumi, Satoshi Yoshimura, Yuji Yamada, Yoko Shioda …

Genes, chromosomes & cancer, 57(10) 525-529, Oct, 2018
Outcome of renal tumors registered in Japan Wilms Tumor Study-2 (JWiTS-2): A report from the Japan Children's Cancer Group (JCCG)

Tsugumichi Koshinaga, Tetsuya Takimoto, Takaharu Oue, Hajime Okita, Yukichi Tanaka, Miwako Nozaki, Kunihiko Tsuchiya, Eisuke Inoue, Masayuki Haruta, Yasuhiko Kaneko …

Pediatric Blood and Cancer, 65(7) e27056, Jul 1, 2018
Outcome of renal tumors registered in Japan Wilms Tumor Study-2 (JWiTS-2): A report from the Japan Children's Cancer Group (JCCG)

Koshinaga, T, Takimoto, T, Oue, T, Okita, H, Tanaka, Y, Nozaki, M, Tsuchiya, K, Inoue, E, Haruta, M, Kaneko, Y …

Pediatr Blood Cancer, 65(7) e27056, Apr 6, 2018 Peer-reviewed
The effect of immune checkpoint inhibitors on lung metastases of osteosarcoma

Takahiro Shimizu, Yasushi Fuchimoto, Kazumasa Fukuda, Hajime Okita, Yuko Kitagawa, Tatsuo Kuroda

Journal of Pediatric Surgery, 52(12) 2047-2050, Dec 1, 2017
Infantile fibrosarcoma treated with postoperative vincristine and dactinomycin

Hiroki Yoshihara, Yuri Yoshimoto, Yosuke Hosoya, Daisuke Hasegawa, Takafumi Kawano, Akiko Sakoda, Hajime Okita, Atsushi Manabe

PEDIATRICS INTERNATIONAL, 59(3) 371-374, Mar, 2017

Presentations

Bcl-2関連遺伝子EATのトランスジェニック・マウスでは，多彩な腫瘍が発生する

Ookita Hajime, Umezawa Akihiro, Matsushita Kenichi, Suzuki Atsushi, Shimoda Kouji, Fukuda Mariko, Sano Makoto, Yamada Taketo, Hata Junichi

第90回日本病理学会総会, Apr, 2001
Molecular analysis of the Ewing family of tumors in japan:EWS/ETS fusion genes are availablefor diagnosis

Okita H, Umezawa A, Urano F, Yabe H, Fukuma M, Hata J

Interanational Congress of the international Academy of Pathology, Oct, 2000 Invited
Islet cells hyperplasia/Adenoma in the EAT transgenic mice

Umezawa A, Matsusita K, Okita H, Suzuki A, Ando T, Shimoda K, Sano M, Fukuma M, Yamada T, Urano F, Hata J

International Congress of the International Academy of Pathology, Oct, 2000 Invited
Bcl-2関連遺伝子EATのトランスジェニック・マウスでは多彩な腫瘍が発生する

Ookita Hajime, Umezawa Akihiro, Matsushita Kenichi, Suzuki Jun, Shimoda Kouji, Fukuma Mariko, Sano Makoto, Yamada Taketo, Hata Junichi

第59回日本癌学会総会, Oct, 2000 Invited
EAT/（Bcl-2関連遺伝子）トランスジェニック・マウスにおける膵ラ氏島の過形成及び腺腫

Ookita Hajime, Umezawa Akihiro, Matsushita Kenichi, Suzuki Jun, Shimoda Kouji, Fukuma Mariko, Sano Makoto, Yamada Taketo, Hata Junichi

第89回日本病理学会, Apr, 2000 Invited
EATトランスジェニックマウスにおける膵ラ氏島の過形成および腺腫

Ookita Hajime, Umezawa Akihiro, Matsushitakenichi, Honda Takahiro, Suzuki Jun, Shimoda Kouji, Fukuma Mariko, Sano Makoto, Yamada Taketo, Hata Junichi

第58回日本癌学会総会, Sep, 1999
Ewing 肉腫にみられるキメラ遺伝子のタイプ別にみた臨床経過の検討

Yabe Hiroki, Yabe Hiroo, Morioka Hideo, Ookita Hajime, Umezawa Akihiro, Hata Junichi

第32回日本整形外科学会，骨・軟部腫瘍学術集会, Jul, 1999
Ewing肉腫にみられるキメラ遺伝子のタイプ別にみた臨床経過の検討

Yabe Hiroki, Yabe Hiroo, Morioka Hideo, Ootaki Hajime, Umezawa Akihiro, Hata Junichi, Toyama Yoshiaki

第32回日本整形外科学会骨・軟部腫瘍学術集会, Jul, 1999
ヒト胎児性癌細胞の分化関連分子EATの生物学的機能

Umezawa Akihiro, Matsushita Kenichi, Suzuki Jun, Shimoda Kouji, Ookita Hajime, Fukuma Mariko, Yamada Taketo, Sano Makoto, Hata Junichi

第88回日本病理学会総会，ワークショップII アポトーシスと疾患, Apr, 1999
Ewing/PNET腫瘍群におけるキメラ遺伝子と標的遺伝子（シンポジウム）

Ookita Hajime, Umezawa Akihiro, Fukuma Mariko, Urano Fumihiko, Hata Junichi

第88回日本病理学会総会, Apr, 1999
ヒト胎児性癌細胞の分化関連分子EATの生物学的機能

Umezawa Akihiro, Matsushita Kenichi, Suzuki Jun, Shimoda Kouji, Ookita Hajime, Fukuma Mariko, Yamada Taketo, Sano Makoto, Hata Junichi

第88回日本病理学会総会, Apr, 1999
Ewing/PNET腫瘍群におけるキメラ遺伝子

Ookita Hajime, Umezawa Akihiro, Urano Fumihiko, Fukuma Mariko, Yabe Hiroki, Hata Junichi

第14回日本小児がん学会, Oct, 1998
Bcl-2関連遺伝子EATの機能解析：化学療法剤によるアポトーシス誘発の抑制―トランスジェニックマウスを用いて―

Suzuki Atsushi, Andou Takashi, Matsushita Kenichi, Shimoda Kouji, Sano Makoto, Ookita Hajime, Yamada Taketo, Umezawa Akihiro, Hata Junichi

第57回日本癌学会総会, Sep, 1998
EATトランスジェニック・マウスにおける膵ラ氏島過形成及び腺腫

Matsushita Kenichi, Suzuki Atsushi, Andou Takashi, Shimoda Kouji, Ookita Hajime, Fukuma Mariko, Yamada Taketo, Sano Makoto, Urano Fumihiko, Umezawa Akihiro, Hata Junichi

第57回日本癌学会総会, Sep, 1998
マウスEAT遺伝子の単離と胎児性癌細胞ならびに胚性幹細胞の分化初期における発現

Ookita Hajime, Umezawa Akihiro, Atsumi Tooru, Suzuki Atsushi, Sano Makoto, Hata Junichi

第57回日本癌学会総会, Sep, 1998
ヒト胎児性癌細胞の分化関連分子EATのアポトーシスに対する機能―トランスジェニック・マウスを用いて

Umezawa Akihiro, Suzuki Atsushi, Andou Takashi, Matsushita Kenichi, Shimoda Kouji, Sano Makoto, Yamada Taketo, Urano Fumihiko, Ookita Hajime, Hata Junichi

第87回日本病理学会総会, Apr, 1998
bcl-2関連遺伝子EATトランスジェニック・マウスにおける膵ラ氏島の過形成

Matsushita Kenichi, Suzuki Atsushi, Andou Takashi, Shimoda Kouji, Ookita Hajime, Fukuma Mariko, Yamada Taketo, Sano Makoto, Urano Fumihiko, Umezawa Akihiro, Hata Junichi

第87回日本病理学会総会, Apr, 1998 Invited
マウスEAT遺伝子の単離と胎児性癌細胞の分化初期における発現

Ookita Hajime, Umezawa Akihiro, Suzuki Atsushi, Hata Junichi

第87回日本病理学会総会, Apr, 1998
Islet cell hyperplasia/adenoma in the EAT transgenic mice

Umezawa Akihiro, Matsushita Kenichi, Suzuki Atsushi, Ando Takashi, Shimoda Kouji, Sano Makoto, Fukuma Mariko, Yamada Taketo, Okita Hajime, Urano Fumihiko, Hata Jun-ichi

AACR/JCR Joint Conference, Innovative Approaches to the Prevention, Diagnosis, and Therapy of Cancer. (4th; 1998; USA), Feb, 1998
Islet cell hyperplasia/adenoma in the EAT transgenic mice

Umezawa A, Matsushita K, Suzuki A, Ando T, Shimoda K, Sano M, Fukuma M, Yamada T, Okita H, Urano F, Hata J

AACR/JCR Joint Conference, Innovative Approaches to the Prevention, Diagnosis, and Therapy of Cancer(4th;1998;Maui,Hawaii), Feb, 1998

Teaching Experience

Apr, 2022 - Mar, 2023

DIAGNOSTIC PATHOLOGY (Keio University)
Apr, 2021 - Mar, 2022

DIAGNOSTIC PATHOLOGY (Keio University)
Apr, 2020 - Mar, 2021

GENERAL PATHOLOGY (Keio University)
Apr, 2020 - Mar, 2021

DISEASES OF ORGAN SYSTEMS (Keio University)
Apr, 2019 - Mar, 2020

GENERAL PATHOLOGY (Keio University)
Apr, 2019 - Mar, 2020

DISEASES OF ORGAN SYSTEMS (Keio University)

Professional Memberships

Research Projects

エピゲノム修飾因子の機能解析による小児固形腫瘍の発症機構解明

Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), MEXT,JSPS, Apr, 2016 - Mar, 2019

大喜多肇
Pediatric cancer

JST Development of Systems and Technology for Advanced Measurement and Analysis
小児固形腫瘍の生物学的特性の研究

厚生労働科学研究費補助金