2010年6月
Inhibitory activity of blasticidin A, a strong aflatoxin production inhibitor, on protein synthesis of yeast: selective inhibition of aflatoxin production by protein synthesis inhibitors
JOURNAL OF ANTIBIOTICS
- ,
- ,
- ,
- ,
- ,
- 巻
- 63
- 号
- 6
- 開始ページ
- 309
- 終了ページ
- 314
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ja.2010.36
- 出版者・発行元
- JAPAN ANTIBIOTICS RESEARCH ASSOC
Blasticidin A (BcA), an antibiotic produced by Streptomyces, inhibits aflatoxin production without strong growth inhibition toward aflatoxin-producing fungi. During the course of our study on the mode of action of BcA by two-dimensional differential gel electrophoresis (2D-DIGE), we found a decrease in the abundances of ribosomal proteins in Saccharomyces cerevisiae after exposure to BcA. This phenomenon was also observed by treatment with blasticidin S (BcS) or cycloheximide. BcA inhibited protein synthesis in a galactose-induced expression system in S. cerevisiae similar to BcS and cycloheximide. BcS, but not cycloheximide, inhibited aflatoxin production in Aspergillus parasiticus without inhibition of fungal growth, similar to BcA. A decrease in the abundances of aflatoxin biosynthetic enzymes was observed in 2D-DIGE experiments with Aspergillus flavus after exposure to BcA or BcS. These results suggested that protein synthesis inhibitors are useful to control aflatoxin production. The Journal of Antibiotics (2010) 63, 309-314; doi:10.1038/ja.2010.36; published online 23 April 2010
- リンク情報
-
- DOI
- https://doi.org/10.1038/ja.2010.36
- CiNii Articles
- http://ci.nii.ac.jp/naid/80021206351
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20414321
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000279418800006&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1038/ja.2010.36
- ISSN : 0021-8820
- CiNii Articles ID : 80021206351
- PubMed ID : 20414321
- Web of Science ID : WOS:000279418800006