2014年1月
Inhibition of endocytic vesicle fusion by Plk1-mediated phosphorylation of vimentin during mitosis
CELL CYCLE
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 13
- 号
- 1
- 開始ページ
- 126
- 終了ページ
- 137
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.4161/cc.26866
- 出版者・発行元
- LANDES BIOSCIENCE
Endocytic vesicle fusion is inhibited during mitosis, but the molecular pathways that mediate the inhibition remain unclear. Here we uncovered an essential role of Polo-like kinase 1 (Plk1) in this mechanism. Phosphoproteomic analysis revealed that Plk1 phosphorylates the intermediate filament protein vimentin on Ser459, which is dispensable for its filament formation but is necessary for the inhibition of endocytic vesicle fusion in mitosis. Furthermore, this mechanism is required for integrin trafficking toward the cleavage furrow during cytokinesis. Our results thus identify a novel mechanism for fusion inhibition in mitosis and implicate its role in vesicle trafficking after anaphase onset.
- リンク情報
-
- DOI
- https://doi.org/10.4161/cc.26866
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/24196446
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925722
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000331449600022&DestApp=WOS_CPL
- URL
- http://europepmc.org/articles/PMC3925722
- URL
- http://orcid.org/0000-0001-7633-8495
- ID情報
-
- DOI : 10.4161/cc.26866
- ISSN : 1538-4101
- eISSN : 1551-4005
- ORCIDのPut Code : 58378613
- PubMed ID : 24196446
- PubMed Central 記事ID : PMC3925722
- Web of Science ID : WOS:000331449600022