2000年8月
Mutations of the bak gene in human gastric and colorectal cancers
CANCER RESEARCH
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- 巻
- 60
- 号
- 16
- 開始ページ
- 4328
- 終了ページ
- 4330
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- AMER ASSOC CANCER RESEARCH
The Bcl-2 homologue Bak is a potent inducer of apoptosis. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the entire coding region of the bak gene (exons 2-6) in 24 primary gastric cancers (6 early-stage and 18 advanced-stage cancers) and 20 primary colorectal cancers (6 early-stage and 14 advanced-stage cancers). The data herein demonstrate, for the first time, the mutation of the bak gene in gastric and colorectal cancers. Missense bak gene mutations were observed in 3 of 24 (12.5%) gastric cancers and 2 of 20 (10.0%) colorectal cancers. Sequence alterations without amino acid alteration were observed 1 of 24 (4.2%) gastric cancers and 2 of 20 (10.0%) colorectal canters. Mutations in the bak gene were observed only in advanced-stage gastrointestinal cancers but not in early-stage cancers. Our observations suggest that mutations in this gene predispose bearers to the development of gastrointestinal malignancies in at least a subset of the cases.
- リンク情報
- ID情報
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- ISSN : 0008-5472
- Web of Science ID : WOS:000088961100007