2013年6月1日
TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1
Journal of General Virology
- 巻
- 94
- 号
- PART 6
- 開始ページ
- 1318
- 終了ページ
- 1324
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1099/vir.0.050252-0
- 出版者・発行元
- Pt 6
TRIM5α restricts human immunodeficiency virus type 1 (HIV-1) infection in cynomolgus monkey (CM) cells. We previously reported that a TRIMCyp allele expressing TRIM5-cyclophilin A fusion protein was frequently found in CMs. Here, we examined the influence of TRIM5 gene variation on the susceptibility of CMs to a monkey-tropic HIV-1 derivative (HIV-1mt) and found that TRIMCyp homozygotes were highly susceptible to HIV-1mt not only in vitro but also in vivo. These results provide important insights into the inter-individual differences in susceptibility of macaques to HIV-1mt. © 2013 SGM.
- リンク情報
-
- DOI
- https://doi.org/10.1099/vir.0.050252-0
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/23486671
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84877949483&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84877949483&origin=inward
- ID情報
-
- DOI : 10.1099/vir.0.050252-0
- ISSN : 0022-1317
- eISSN : 1465-2099
- PubMed ID : 23486671
- SCOPUS ID : 84877949483