MISC

1998年11月

Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520 - II. Physico-chemical properties and structure elucidation

JOURNAL OF ANTIBIOTICS
  • K Suzuki
  • ,
  • S Yahara
  • ,
  • Y Kido
  • ,
  • K Nagao
  • ,
  • Y Hatano
  • ,
  • M Uyeda

51
11
開始ページ
999
終了ページ
1003
記述言語
英語
掲載種別
DOI
10.7164/antibiotics.51.999
出版者・発行元
JAPAN ANTIBIOT RES ASSN

Topostatin is a new topoisomerase inhibitor isolated from the culture filtrate of Thermomonospora alba strain No. 1520. The inhibitor inhibits topoisomerases I and II, and it has neither ability to stabilize the cleavable complex nor ability to intercalate into DNA strands. The molecular formula of topostatin was determined as C36H58N4O11S based on the FAB-MS analyses, and the structure was elucidated to be a novel 14-membered ring containing peptide and terpenoid by various NMR spectroscopies.

Web of Science ® 被引用回数 : 15

リンク情報
DOI
https://doi.org/10.7164/antibiotics.51.999
CiNii Articles
http://ci.nii.ac.jp/naid/10005885594
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9918392
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000077211700004&DestApp=WOS_CPL