竹田直樹 (Naoki Takeda) - マイポータル

基本情報

所属: 熊本大学生命資源研究・支援センター熊本大学生命資源研究・支援センター技術開発助教

J-GLOBAL ID: 200901045438279581
researchmap会員ID: 1000320111

研究分野

ライフサイエンス / 実験動物学 /

経歴

2003年 - 2007年

助手
2003年 - 2007年

Research Associate,
2007年

熊本大学生命資源研究・支援センター技術開発助教
2007年

Assistant Professor, ,Institute of Resource Development and Analysis ,Kumamoto University
1998年 - 2003年

熊本大学助手
1998年 - 2003年

Research Associate,Kumamoto University
1998年

助手
1998年

Research Associate,

学歴

- 1997年

熊本大学, 理学研究科, 修士課程
- 1997年

熊本大学
- 1995年

放送大学, 教養学部
- 1995年

The University of the Air, Faculty of Liberal Arts

論文

Recessive mutation in CD2AP causes focal segmental glomerulosclerosis in humans and mice.

Takano T, Bareke E, Takeda N, Aoudjit L, Baldwin C, Pisano P, Matsuda J, El Andalousi J, Muhtadie L, Bernard C …

Kidney international 95(1) 57-61 2019年1月査読有り
Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine.

Kawaguchi M, Yamamoto K, Takeda N, Fukushima T, Yamashita F, Sato K, Kitamura K, Hippo Y, Janetka JW, Kataoka H

Communications biology 2(1) 11 2019年査読有り
Author Correction: Meikin is a conserved regulator of meiosis-I-specific kinetochore function.

Kim J, Ishiguro KI, Nambu A, Akiyoshi B, Yokobayashi S, Kagami A, Ishiguro T, Pendas AM, Takeda N, Sakakibara Y …

Nature 563(7731) E23 2018年11月査読有り
Independent modes of disease repair by AIM protein distinguished in AIM-felinized mice.

Sugisawa R, Komatsu G, Hiramoto E, Takeda N, Yamamura KI, Arai S, Miyazaki T

Scientific reports 8(1) 13157-13157 2018年9月査読有り
Accumulation of HLA-DR4 in Colonic Epithelial Cells Causes Severe Colitis in Homozygous HLA-DR4 Transgenic Mice

Atsushi Irie, Takahisa Imamura, Yayoi Michibata, Ttatsuko Kubo, Naoki Takeda, Isao Shibuya, Shinji Sogo, Kimi Araki, Yasuharu Nishimura

INFLAMMATORY BOWEL DISEASES 23(12) 2121-2133 2017年12月査読有り
Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo

Takao Iwawaki, Ryoko Akai, Takae Toyoshima, Naoki Takeda, Tomo-o Ishikawa, Ken-ichi Yamamura

SCIENTIFIC REPORTS 7 46230 2017年4月査読有り
Inflammatory and anti-inflammatory states of adipose tissue in transgenic mice bearing a single TCR

Ayaka Matsumoto, Kaori Taniguchi, Naoki Takeda, Ken-ichi Yamamura, Satoko Arai, Toru Miyazaki

INTERNATIONAL IMMUNOLOGY 29(1) 21-30 2017年1月査読有り
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.

Hiroki Tanigawa, Keishi Miyata, Zhe Tian, Jun Aoi, Tsuyoshi Kadomatsu, Satoshi Fukushima, Aki Ogata, Naoki Takeda, Jiabin Zhao, Shunshun Zhu …

Scientific reports 6 34690-34690 2016年10月4日査読有り
Impact of feline AIM on the susceptibility of cats to renal disease

Ryoichi Sugisawa, Emiri Hiramoto, Shigeru Matsuoka, Satomi Iwai, Ryosuke Takai, Tomoko Yamazaki, Nobuko Mori, Yuki Okada, Naoki Takeda, Ken-ichi Yamamura …

SCIENTIFIC REPORTS 6 35251 2016年10月査読有り
ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism

Zhe Tian, Keishi Miyata, Tsuyoshi Kadomatsu, Haruki Horiguchi, Hiroyuki Fukushima, Shugo Tohyama, Yoshihiro Ujihara, Takahiro Okumura, Satoshi Yamaguchi, Jiabin Zhao …

NATURE COMMUNICATIONS 7 13016 2016年9月査読有り
Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development

Hisayoshi Omori, Soichiro Ogaki, Daisuke Sakano, Mutsumi Sato, Kahoko Umeda, Naoki Takeda, Naomi Nakagata, Shoen Kume

FEBS Letters 590(16) 2584-2593 2016年8月1日査読有り
Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background

Jingling Shen, Dan Shi, Tomohiro Suzuki, Zunping Xia, Hanli Zhang, Kimi Araki, Shigeharu Wakana, Naoki Takeda, Ken-ichi Yamamura, Shoude Jin …

LABORATORY INVESTIGATION 96(6) 680-691 2016年6月査読有り
Viable offspring obtained from Prm1-deficient sperm in mice

Naoki Takeda, Kazuya Yoshinaga, Kenryo Furushima, Kazufumi Takamune, Zhenghua Li, Shin-ichi Abe, Shin-ichi Aizawa, Ken-ichi Yamamura

SCIENTIFIC REPORTS 6 27409 2016年6月査読有り
Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo.

Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K

Scientific reports 5 17205 2015年11月査読有り
Determining c-Myb Protein Levels Can Isolate Functional Hematopoietic Stem Cell Subtypes

Hiroshi Sakamoto, Naoki Takeda, Fumio Arai, Kentaro Hosokawa, Paloma Garcia, Toshio Suda, Jon Frampton, Minetaro Ogawa

STEM CELLS 33(2) 479-490 2015年2月査読有り
Meikin is a conserved regulator of meiosis-I-specific kinetochore function

Jihye Kim, Kei-ichiro Ishiguro, Aya Nambu, Bungo Akiyoshi, Shihori Yokobayashi, Ayano Kagami, Tadashi Ishiguro, Alberto M. Pendas, Naoki Takeda, Yogo Sakakibara …

NATURE 517(7535) 466-+ 2015年1月査読有り
Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice

Koichiro Susa, Eisei Sohara, Tatemitsu Rai, Moko Zeniya, Yutaro Mori, Takayasu Mori, Motoko Chiga, Naohiro Nomura, Hidenori Nishida, Daiei Takahashi …

HUMAN MOLECULAR GENETICS 23(19) 5052-5060 2014年10月査読有り
Establishment of HLA-DR4 Transgenic Mice for the Identification of CD4(+) T Cell Epitopes of Tumor-Associated Antigens

Junji Yatsuda, Atsushi Irie, Kumiko Harada, Yayoi Michibata, Hirotake Tsukamoto, Satoru Senju, Yusuke Tomita, Akira Yuno, Masatoshi Hirayama, Mohammad Abu Sayem …

PLOS ONE 8(12) e84908 2013年12月査読有り
Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.

Keiko Ikeda, Shin'Ichiro Satake, Tatsushi Onaka, Hiroki Sugimoto, Naoki Takeda, Keiji Imoto, Kiyoshi Kawakami

The Journal of physiology 591(13) 3433-49 2013年7月1日査読有り
Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells

Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Naoki Takeda, Chika Sakamoto, Hirotaka Kawano, Takenobu Nii, Shohei Miyamato, Yoko Nagai …

Molecular Therapy 21(6) 1242-1250 2013年査読有り

もっとみる

MISC

Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII

Masayoshi Souri, Shiori Koseki-Kuno, Naoki Takeda, Mitsunori Yamakawa, Yasuchika Takeishi, Jay L. Degen, Akitada Ichinose

THROMBOSIS AND HAEMOSTASIS 99(2) 401-408 2008年2月
Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice

Masayoshi Souri, Shiori Koseki-Kuno, Naoki Takeda, Jay L. Degen, Akitada Ichinose

INTERNATIONAL JOURNAL OF HEMATOLOGY 87(1) 60-68 2008年1月
The Rab8 GTPase regulates apical protein localization in intestinal cells

Takashi Sato, Sotaro Mushiake, Yukio Kato, Ken Sato, Miyuki Sato, Naoki Takeda, Keiichi Ozono, Kazunori Miki, Yoshiyuki Kubo, Akira Tsuji …

NATURE 448(7151) 366-369 2007年7月
Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice.

87(1) 60-60 2007年
Heat shock protein 40/DjB1 is required for thermotolerance in early phase

Yukako Uchiyama, Naoki Takeda, Masataka Mori, Kazutoyo Terada

JOURNAL OF BIOCHEMISTRY 140(6) 805-812 2006年12月
Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe

H Niida, S Tsuge, Y Katsuno, A Konishi, N Takeda, M Nakanishi

JOURNAL OF BIOLOGICAL CHEMISTRY 280(47) 39246-39252 2005年11月
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

M Tachibana, J Ueda, M Fukuda, N Takeda, T Ohta, H Iwanari, T Sakihama, T Kodama, T Hamakubo, Y Shinkai

GENES & DEVELOPMENT 19(7) 815-826 2005年4月
A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis

K Terada, K Yomogida, T Imai, H Kiyonari, N Takeda, T Kadomatsu, M Yano, S Aizawa, M Mori

EMBO JOURNAL 24(3) 611-622 2005年2月
Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) Is Required for Branching Morphogenesis in the Chorioallantoic Placenta

Hiroyuki Tanaka, Koki Nagaike, Naoki Takeda, Hiroshi Itoh, Kazuyo Kohama, Tsuyoshi Fukushima, Shiro Miyata, Shuichiro Uchiyama, Shunro Uchinokura, Takeshi Shimomura …

MOLECULAR AND CELLULAR BIOLOGY 25(13) 5687-5687 2005年
Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

Noriyuki Kuroda, Tasuku Mitani, Naoki Takeda, Naozumi Ishimaru, Rieko Arakaki, Yoshio Hayashi, Yoshimi Bando, Keisuke Izumi, Takeshi Takahashi, Takashi Nomura …

The Journal of Immunology 2005年
Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) Is Required for Branching Morphogenesis in the Chorioallantoic Placenta

25(13) 5687-5687 2005年
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

(19) 815-815 2005年
N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing

K Uchimura, K Kadomatsu, FM El-Fasakhany, MS Singer, M Izawa, R Kannagi, N Takeda, SD Rosen, T Muramatsu

JOURNAL OF BIOLOGICAL CHEMISTRY 279(33) 35001-35008 2004年8月
Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities

S Yamazaki, R Iwamoto, K Saeki, M Asakura, S Takashima, A Yamazaki, R Kimura, H Mizushima, H Moribe, S Higashiyama …

JOURNAL OF CELL BIOLOGY 163(3) 469-475 2003年11月
Bcl11b is required for differentiation and survival of alpha beta T lymphocytes

Y Wakabayashi, H Watanabe, J Inoue, N Takeda, J Sakata, Y Mishima, J Hitomi, T Yamamoto, M Utsuyama, O Niwa …

NATURE IMMUNOLOGY 4(6) 533-539 2003年6月
Expression of Tom34 splicing isoforms in mouse testis and knockout of Tom34 in mice

K Terada, S Ueno, K Yomogida, T Imai, H Kiyonari, N Takeda, M Yano, S Abe, S Aizawa, M Mori

JOURNAL OF BIOCHEMISTRY 133(5) 625-631 2003年5月
Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion.

Senoo M, Wang L, Suzuki D, Takeda N, Shinkai Y, Habu S

J Immunol. 171 829-829 2003年
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis

Y Komatsu, H Shibuya, N Takeda, J Ninomiya-Tsuji, T Yasui, K Miyado, T Sekimoto, N Ueno, K Matsumoto, G Yamada

MECHANISMS OF DEVELOPMENT 119(2) 239-249 2002年12月
A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation

Y Shinkai, H Satoh, N Takeda, M Fukuda, E Chiba, T Kato, T Kuramochi, Y Araki

MOLECULAR AND CELLULAR BIOLOGY 22(10) 3276-3280 2002年5月
Otx2 is required to respond to signals from anterior neural ridge for forebrain specification

E Tian, C Kimura, N Takeda, S Aizawa, Matsuo, I

DEVELOPMENTAL BIOLOGY 242(2) 204-223 2002年2月

もっとみる

所属学協会

発生生物学会

Works(作品等)

プロタミンノックアウトマウスを用いた精子の核凝縮とRNA制御機構の解明

2007年 - 2008年
無力精子症様を示す遺伝子改変マウスの機能解析

2005年 - 2007年
精子の機能障害による生殖不全機構の解明

2002年 - 2004年
可変型遺伝子トラップによる挿入突然変異マウス作製とそのカタログ化

2000年 - 2001年