Ishikawa Toshihisa

J-GLOBAL         Last updated: Apr 30, 2010 at 00:00
 
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Name
Ishikawa Toshihisa
URL
http://www.humanABC.bio.titech.ac.jp
Affiliation
Former Institution / Organization Tokyo Institute of Technology Graduate School of Biosciences and Biotechnology Department of Biomolecular Engineering
Job title
Professor,Others,Others
Degree
Doctor of Science(Hokkaido University)

Research Areas

 
 

Academic & Professional Experience

 
1982
 - 
1983
:University Dusseldorf Deutsher Akademischer Austauschdienst (DAAD) Scholor
 
1983
 - 
1987
:University Dusseldorf Postdoctoral Fellow
 
1987
 - 
1989
:Osaka University Medical School Assistant Biochemist
 
1989
 - 
1991
:German Cancer Reseach Center Project Leader
 
1991
 - 
1995
:Universty of Texas, M. D. Anderson Cancer Center Assistant Professor
 

Education

 
 
 - 
1982
Research Institute of Applied Electricity, Graduate School, Division of Natural Science, Hokkaido University
 
 
 - 
1977
Faculty of Science, Hokkaido University
 

Committee Memberships

 
2000
   
 
Chem-Bio Informatics Society  
 
2002
   
 
Genomic Drug Discovery Forum  
 
2008
   
 
Japanese Society for the Study of Xenobiotics  
 
2002
 - 
2008
The Biochemical Society  Biochemical Journal Editorial Board/Advisory panel
 

Awards & Honors

 
1993
The 1993 Research Award (International Life sciences Institute, Washington D.C.)
 
2001
The First Biobuisiness Competition JAPAN
 
1982
Deutscher Akademischer Austauschdienst
 

Misc

 
Is the Glutathione S-Conjugate Carrier an mdr1 Gene Product?
Ishikawa, T.
Trends in Biochem. Sci.   15 219-220   1990
Sakurai, A. Tamura, A. Onishi Y. Ishikawa, T.
Expert Opin Pharmacother   6(14) 2455-2473   2005
Ishikawa, T. Onishi, Y. Hirano, H. Oosumi, K. Nagakura, M. Tarui, S.
Biol. Pharm. Bull.   27(7) 939-948   2004
Cardiac Transport of Glutathione Disulfide and S-Conjugate: Studies with Isolated Perfused Rat Heart during Hydroperoxide Metabolism.
Ishikawa, T. Sies, H.
J. Biol. Chem.   259 3838-3843   1984
Brefeldin A Binds to Glutathione S-Transferase and Is Secreted as Glutathione and Cysteine Conjugates by Chinese Hamster Ovary Cells.
Bruing, A. Ishikawa, T. Kneusel, R.E. Matern, U. Lottspeich, F. Wieland, F.
J. Biol. Chem.   267 7726-7732   1992

Books etc

 
Cell Growth Inhibition by Antitumor Prostaglandins and Its Modulation by MRP/GS-X Pump.
Advances in Experimental Medicine and Biology Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury, Honn, K.V., Marnett, L.J., and Wong, P.Y. (eds.) Plenum Press, New York   1997   
Transport of Cysteinyl Leukotrienes.
Transport of Amino Acids. Haussinger, D. and Kilberg, M. (eds.) Academic Press, New York   1992   
Glutathione Conjugation and ATP-dependent Export of Anticancer Drugs.
Drug Transport in Antimicrobial and Anticancer DrugsGeorgopapadakou, N.H. (ed.), Marcel Dekker, New York   1994   
Transport of Glutathione S-Conjugates from Cancer Cells: Function and Structure of GS-X Pump.
Vermeulen, N.P.E., Mulder, G.J., Nieuwenhuyse, H., Peters, W.H.M., van Bladeren, P.J. (eds.) Glutathione S-Transferases: Structure, function, and clinical implications. Taylor and Francis, London   1996   
The Basic Science of Oncology・ Chapter 18 Drug Resistance
2006   

Conference Activities & Talks

 
Intramolecular disulfide bond is a critical checkpoint determining degradative fates of ABC transporter ABCG2 protein.
2007   
Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2
2008   

Works

 
In vivo Molecular Science for Discovery of New Biofunctions and Pharmaceutical Drugs
2001 - 2006

Research Grants & Projects

 
Functional Analysis of ABC transporters and their genetic polymorphism
Identification of intracellular targets for anti-tumor prostaglandins
Toxicogenomic screening for drugs using in vitro liver system
In vivo Molecular Science for Discovery of New Biofunctions and Pharmaceutical Drugs
Grant-in-Aid for Scientific Research
Project Year: 2001 - 2006
design
Grant-in-Aid for Scientific Research
Project Year: 2002 - 2004