2010年
Insights into the structures of DNA damaged by hydroxyl radical: Crystal structures of DNA duplexes containing 5-formyluracil
Journal of Nucleic Acids
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- 巻
- 2010
- 号
- 開始ページ
- 107289
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.4061/2010/107289
Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. One of the major damaged thymine derivatives is 5-formyluracil (fU), which induces pyrimidine transition during replication. In order to establish the structural basis for such mutagenesis, the crystal structures of two kinds of DNA d(CGCGRATfUCGCG) with R = A/G have been determined by X-ray crystallography. The fU residues form a Watson-Crick-type pair with A and two types of pairs (wobble and reversed wobble) with G, the latter being a new type of base pair between ionized thymine base and guanine base. In silico structural modeling suggests that the DNA polymerase can accept the reversed wobble pair with G, as well as the Watson-Crick pair with A. © 2010 Masaru Tsunoda et al.
- リンク情報
- ID情報
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- DOI : 10.4061/2010/107289
- ISSN : 2090-0201
- ISSN : 2090-021X
- SCOPUS ID : 84869005984