MISC

2001年8月

Effect of endogenous dopamine on extrastriatal [C-11]FLB 457 binding measured by PET

SYNAPSE
  • T Okauchi
  • ,
  • T Suhara
  • ,
  • J Maeda
  • ,
  • K Kawabe
  • ,
  • S Obayashi
  • ,
  • K Suzuki

41
2
開始ページ
87
終了ページ
95
記述言語
英語
掲載種別
DOI
10.1002/syn.1063
出版者・発行元
WILEY-LISS

Central dopaminergic systems are known to be implicated in the pathophysiology of schizophrenia and recent in vivo dopamine receptor imaging studies have focused on the measurement of extrastriatal dopamine receptor. However, there are only a limited number of ligands that can measure the low-density D, receptor in extrastriatal regions and their sensitivity to endogenous dopamine in extrastriatal regions has not yet been fully examined. In this study, the effect of endogenous dopamine on the extrastriatal binding of [C-11]FLB 457 was examined in the rhesus monkey after facilitation with 1 mg/kg of methamphetamine (MAP) and was compared with the effect on the striatal binding of [C-11]raclopride. The indices of receptor binding were obtained by four methods using cerebellum as a reference region. The bindings of [C-11]FLB 457 in the frontal cortex, temporal cortex, and thalamus were not significantly changed after MAP treatment, while the striatal binding of [C-11]raclopride was decreased by more than 20%. These results suggest that [C-11]FLB 457 is not sensitive to endogenous dopamine in the extrastriatal regions of rhesus monkeys, despite a sufficient dose of MAP to decrease the binding of [C-11]raclopride in the striatum. (C) 2001 Wiley-Liss, Inc.

Web of Science ® 被引用回数 : 57

リンク情報
DOI
https://doi.org/10.1002/syn.1063
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000169303500001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/syn.1063
  • ISSN : 0887-4476
  • Web of Science ID : WOS:000169303500001

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