論文

査読有り
2015年7月

Hippocampal AP5 treatment impairs both spatial working and reference memory in radial maze performance in rats

EUROPEAN JOURNAL OF PHARMACOLOGY
  • Kazuo Yamada
  • ,
  • Makoto Shimizu
  • ,
  • Kouichi Kawabe
  • ,
  • Yukio Ichitani

758
開始ページ
137
終了ページ
141
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ejphar.2015.03.080
出版者・発行元
ELSEVIER SCIENCE BV

The possible involvement of hippocampal N-methyl-D-aspartate (NMDA) receptors in spatial reference and working memory was investigated. Rats were first trained in a four-baited/four-unbaited version of the eight-arm radial maze task in which only predetermined four arms for each rat were baited with a Food pellet. After rats reached the learning criterion, their performance was tested under the treatment of a NMDA antagonist, AP5 (D,L-2-amino-5-phosphonopentanoic acid, 20-40 nmol), or vehicle into the dorsal hippocampus through the bilaterally implanted guide cannulae. AP5 produced dose-dependent increments on both reference and working memory errors, but did not have any effect on the running speed. Additionally, there were significant correlations between the number of trials to criterion in acquisition and the number of reference and working memory errors induced by AP5 treatment. The results suggest that hippocampal NMDA receptors are involved in both spatial reference and working memory. (C) 2015 Elsevier By. All rights reserved,

Web of Science ® 被引用回数 : 14

リンク情報
DOI
https://doi.org/10.1016/j.ejphar.2015.03.080
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25863255
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000353787300018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.ejphar.2015.03.080
  • ISSN : 0014-2999
  • eISSN : 1879-0712
  • PubMed ID : 25863255
  • Web of Science ID : WOS:000353787300018

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