- LIPPINCOTT WILLIAMS & WILKINS
This study was carried out to investigate the long-term effects of chronic neonatal antagonism of N-methyl-D-aspartate (NMDA) receptors, a subtype of glutamate receptors, on working memory. Rats were tested on the delayed nonmatching-to-position task in adulthood after repeated treatment of a noncompetitive NMDA antagonist MK-801 in postnatal days 7-20. As a result, this treatment led to deficits in learning and/or performance of delayed non matching-to-position responses, suggesting that chronic neo-natal NMDA antagonism persistently impairs working memory. Furthermore, it decreased body and brain weight, and induced stereotyped head-rotation behavior. As working memory deficits are shown in several mental disorders such as schizophrenia and developmental disorders, rats with chronic neonatal NMDA antagonism might be useful for a better understanding of these disorders.
Web of Science ® 被引用回数 : 20
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- DOI : 10.1097/WNR.0b013e328302ee31
- ISSN : 0959-4965
- PubMed ID : 18521003
- Web of Science ID : WOS:000256741800014