論文

査読有り
2008年6月

Effects of neonatal repeated MK-801 treatment on delayed non matching-to-position responses in rats

NEUROREPORT
  • Kouichi Kawabe
  • ,
  • Eri Miyamoto

19
9
開始ページ
969
終了ページ
973
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/WNR.0b013e328302ee31
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

This study was carried out to investigate the long-term effects of chronic neonatal antagonism of N-methyl-D-aspartate (NMDA) receptors, a subtype of glutamate receptors, on working memory. Rats were tested on the delayed nonmatching-to-position task in adulthood after repeated treatment of a noncompetitive NMDA antagonist MK-801 in postnatal days 7-20. As a result, this treatment led to deficits in learning and/or performance of delayed non matching-to-position responses, suggesting that chronic neo-natal NMDA antagonism persistently impairs working memory. Furthermore, it decreased body and brain weight, and induced stereotyped head-rotation behavior. As working memory deficits are shown in several mental disorders such as schizophrenia and developmental disorders, rats with chronic neonatal NMDA antagonism might be useful for a better understanding of these disorders.

Web of Science ® 被引用回数 : 20

リンク情報
DOI
https://doi.org/10.1097/WNR.0b013e328302ee31
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18521003
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000256741800014&DestApp=WOS_CPL
ID情報
  • DOI : 10.1097/WNR.0b013e328302ee31
  • ISSN : 0959-4965
  • PubMed ID : 18521003
  • Web of Science ID : WOS:000256741800014

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