論文

査読有り
2002年2月

A positron-emitter labeled Glycine(B) site antagonist, [C-11]L-703,717, preferentially binds to a cerebellar NMDA receptor subtype consisting of GluR epsilon 3 subunit in vivo, but not in vitro

SYNAPSE
  • T Haradahira
  • ,
  • T Okauchi
  • ,
  • J Maeda
  • ,
  • MR Zhang
  • ,
  • T Kida
  • ,
  • K Kawabe
  • ,
  • M Mishina
  • ,
  • Y Watanabe
  • ,
  • K Suzuki
  • ,
  • T Suhara

43
2
開始ページ
131
終了ページ
133
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/syn.10029
出版者・発行元
WILEY-LISS

In previous studies, we have found that [C-11]L-703,717, a positron-emitter labeled antagonist for the glycine-binding site of NMDA receptors, only localizes in rodent cerebellum under in vivo conditions. In order to understand the unusual cerebellar localization, we have examined the binding of [C-11]L-703,717 to a cerebellar-specific NMDA receptor subtype consisting of GLuR epsilon3 subunit, by comparing its auto-radiographic distributions between GluR epsilon3-deficient and wild-type mice. Ex vivo [C-11]L-703,717 binding to wild-type mice showed a highly specific localization of radioactivity in the cerebellum, whereas that to the GluR epsilon3-deficient mice showed no specific localization of radioactivity in any of the brain regions. In contrast to the ex vivo binding, in vitro [C-11]L-703,717 binding displayed a similar binding characteristic between GluR epsilon3-deficient and wild-type mice with highly specific localizations in the hippocampus and cerebral cortex. Therefore, the present study clearly demonstrated that [C-11]L-703,717 preferentially binds to a cerebellar NMDA receptor subtype consisting of GluR epsilon3 subunit in vivo, but not in vitro. (C) 2001 Wiley-Liss, Inc.

Web of Science ® 被引用回数 : 13

リンク情報
DOI
https://doi.org/10.1002/syn.10029
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11754492
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000173040200006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/syn.10029
  • ISSN : 0887-4476
  • PubMed ID : 11754492
  • Web of Science ID : WOS:000173040200006

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