論文

査読有り
2016年9月

1 '-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells

CHEMICO-BIOLOGICAL INTERACTIONS
  • Akiko Kojima-Yuasa
  • ,
  • Tomiya Yamamoto
  • ,
  • Keisuke Yaku
  • ,
  • Shiori Hirota
  • ,
  • Shigeo Takenaka
  • ,
  • Kouichi Kawabe
  • ,
  • Isao Matsui-Yuasa

257
開始ページ
101
終了ページ
109
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cbi.2016.07.031
出版者・発行元
ELSEVIER IRELAND LTD

1 '-Acetoxychavicol acetate (ACA) is naturally obtained from the rhizomes and seeds of Alpinia galangal. Here, we examined the effect of ACA on learning and memory in senescence-accelerated mice prone 8 (SAMP8). In mice that were fed a control diet containing 0.02% ACA for 25 weeks, the learning ability in the Morris water maze test was significantly enhanced in comparison with mice that were fed the control diet alone. In the Y-maze test, SAMP8 mice showed decreased spontaneous alterations in comparison with senescence-accelerated resistant/1 (SAMR1) mice, a homologous control, which was improved by ACA pretreatment. Serum metabolite profiles were obtained by GC-MS analysis, and each metabolic profile was plotted on a 3D score plot. Based upon the diagram, it can be seen that the distribution areas for the three groups were completely separate. Furthermore, the contents of B-hydroxybutyric acid and palmitic acid in the serum of SAMP8-ACA mice were higher than those of SAMP8-control mice and SAMR1-control mice. We also found that SAMR1 mice did not show histological abnormalities, whereas histological damage in the CM region of the hippocampus in SAMP8-control mice was observed. However, SAMP8-ACA mice were observed in a similar manner as SAMR1 mice. These findings confirm that ACA increases the serum concentrations of beta-hydroxybutyric acid and palmitic acid levels and thus these fuels might contribute to the maintenance of the cognitive performance of SAMP8 mice. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1016/j.cbi.2016.07.031
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27481192
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000383526800012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.cbi.2016.07.031
  • ISSN : 0009-2797
  • eISSN : 1872-7786
  • PubMed ID : 27481192
  • Web of Science ID : WOS:000383526800012

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