論文

1998年12月

Intrahippocampal D-cycloserine improves MK-801-induced memory deficits: radial-arm maze performance in rats

BRAIN RESEARCH
  • K Kawabe
  • ,
  • T Yoshihara
  • ,
  • Y Ichitani
  • ,
  • T Iwasaki

814
1-2
開始ページ
226
終了ページ
230
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0006-8993(98)01043-9
出版者・発行元
ELSEVIER SCIENCE BV

In order to investigate whether strychnine-insensitive glycine sites coupled with hippocampal NMDA( N-methyl-D-aspartate) receptors are involved in spatial memory in rats, we examined the effects of intrahippocampal treatment of D-cycloserine (DCS), a glycine-site agonist, on spatial-memory deficits which were produced by an NMDA antagonist MK-801 (dizocilpine) on the radial-arm maze task. After the acquisition of this task, the radial-maze performance was tested under the combined treatments of intraperitoneal MK-801 or saline (SAL) and intrahippocampal DCS or SAL. The results showed that MK-801 impaired the performance, and that DCS improved the MK-801-induced performance impairment. These results suggest that glycine sites are involved in spatial memory through their modulatory action on hippocampal NMDA receptors. (C) 1998 Elsevier Science B.V. All rights reserved.

Web of Science ® 被引用回数 : 40

リンク情報
DOI
https://doi.org/10.1016/S0006-8993(98)01043-9
CiNii Articles
http://ci.nii.ac.jp/naid/30003066197
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9838131
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000077849300027&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0006-8993(98)01043-9
  • ISSN : 0006-8993
  • CiNii Articles ID : 30003066197
  • PubMed ID : 9838131
  • Web of Science ID : WOS:000077849300027

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