論文

査読有り
2001年

Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo

Synapse
  • Takashi Okauchi
  • ,
  • Tetsuya Suhara
  • ,
  • Jun Maeda
  • ,
  • Kouichi Kawabe
  • ,
  • Shigeru Obayashi
  • ,
  • Kazutoshi Suzuki

41
2
開始ページ
172
終了ページ
175
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/syn.1071

The activity of DOPA decarboxylase measured in homogenates from rat striatum, or calculated from the rate of tracer decarboxylation measured ex vivo, is stimulated following acute treatment with antagonists of dopamine D2-like receptors. We used compartmental kinetics to test the hypothesis that utilization of the DOPA decarboxylase substrate [18F]fluorodopa is potentiated in living striatum following acute treatment with a typical neuroleptic. The kinetics of the tracer uptake were determined in eight anesthetized female pigs (40 kg) and in three animals receiving an infusion of haloperidol (75 μg kg-1 h-1) for 1 h prior to tracer administration and throughout the 2-h positron emission recording. The relative activity of DOPA decarboxylase in striatum was increased threefold by the treatment. This potentiation of DOPA decarboxylation after pharmacological blockade of dopamine D2-like receptors may be used to optimize the utilization of exogenous DOPA in the treatment of Parkinson's disease. © 2001 Wiley-Liss, Inc.

リンク情報
DOI
https://doi.org/10.1002/syn.1071
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11400183
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034965097&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0034965097&origin=inward
ID情報
  • DOI : 10.1002/syn.1071
  • ISSN : 0887-4476
  • PubMed ID : 11400183
  • SCOPUS ID : 0034965097

エクスポート
BibTeX RIS