NAKAGAWA HIROSHI

J-GLOBAL         Last updated: Nov 25, 2019 at 09:14
 
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Name
NAKAGAWA HIROSHI
Affiliation
Chubu University
Section
College of Bioscience and Biotechnology
Job title
Assistant Professor
Degree
Doctor of Engineering(Tokyo Institute of Technology)
ORCID ID
0000-0002-9697-164X

Research Areas

 
 

Academic & Professional Experience

 
Apr 2019
 - 
Today
Associate Professor, Department of Applied Biological Chemistry, College of Bioscience and Biotechnology, Chubu University
 
Aug 2019
 - 
Sep 2019
The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery, Heidelberg University Hospital
 
Apr 2018
 - 
Mar 2019
Associate Professor, Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University
 
Mar 2019
 - 
Mar 2019
The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery, Heidelberg University Hospital
 
Jul 2018
 - 
Aug 2018
Visiting scientist, The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery, Heidelberg University Hospital
 
Mar 2018
 - 
Mar 2018
Visiting scientist, The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery, Heidelberg University Hospital
 
Sep 2010
 - 
Nov 2017
Lecturer, Department of Applied Biological Chemistry, College of Bioscience and Biotechnology, Chubu University
 
Aug 2017
 - 
Sep 2017
Visiting scientist, The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery, Heidelberg University Hospital
 
Dec 2017
 - 
Mar 2017
Lecturer, Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University
 
Feb 2017
 - 
Mar 2017
Visiting scientist, The laboratory of Dr. Jochen Heß at Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery, Heidelberg University Hospital
 

Education

 
Apr 2001
 - 
Mar 2004
Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
 
Apr 2001
 - 
Mar 2004
the laboratory of Prof. Keiji Hasumi, Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology
 
 
 - 
2004
Graduate School, Division of Life Science and Engineering, Tokyo Institute of Technology
 
Apr 1999
 - 
Mar 2001
Department of Biotechnology, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
 
Apr 1995
 - 
Mar 1999
Department of Bioengineering, School of Bioscience and Biotechnology, Tokyo Institute of Technology
 

Awards & Honors

 
Mar 2010
The impacts of posttranslational modifications and non-synonymous SNPs on the protein stability of human ABC transporter ABCG2 protein in culture cells., Special ABC2010 Poster Recognition Award, FEBS-ABC2010 - 3rd FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases.
 

Published Papers

 
Parallel Synthesis and Biological Evaluation of Destruxin E Analogs Modified with a Side Chain in the α-Hydroxycarboxylic Acid Moiety.
Yoshida, M., Adachi, K., Murase, H., Nakagawa, H., and Doi, T.
European J Org Chem.      2019   [Refereed]
A human ABC transporter ABCC4 gene SNP (rs11568658, 559 G>T, G187W) reduces ABCC4-dependent drug resistance.
Tsukamoto, M., Yamashita, M., Nishi, T., and Nakagawa, H.
Cells      2019   [Refereed]
Nakagawa H, Toyoda Y, Albrecht T, Tsukamoto M, Praetorius M, Ishikawa T, Kamiya K, Kusunoki T, Ikeda K, Sertel S
Medical hypotheses   114 19-22   May 2018   [Refereed]
Possible Association between Middle Ear Cholesteatoma and A Single Nucleotide Polymorphism 538G>A in ABCC11, A Human Earwax Type Determinant.
Kusunoki, T., Nakagawa, H., Tsukamoto, M., Toyoda, Y., Kamiya, K., Okada, H., Hara, S., Furukawa, M. and Ikeda, K.
J. Mol. Genet. Med.   12 362-364   2018   [Refereed]
Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts.
Efferth, T., Banerjee, M., Abu-Darwish, MS., Abdelfatah, S., Böckers, M., Bhakta-Guha, D., Bolzani, V., Daak, S., Demirezer, ÖL., Dawood, M., Efferth, M., El-Seedi, HR., Fischer, N., Greten, HJ., Hamdoun, S., Hong, C., Horneber, M., Kadioglu, O., Khalid, HE., Khalid, SA., Kuete, V., Mahmoud, N., Marin, J., Mbaveng, A., Midiwo, J., Nakagawa, H., Naß, J., Ngassapa, O., Ochwang'I, D., Omosa, LK., Ooko, EA., Özenver, N., Poornima, P., Romero, MR., Saeed, MEM., Salgueiro, L., Seo, EJ., Yan, G., Yasin, Z., Saeed, EM., and Paul, NW.
Phytomedicine   11 30190-30199   2018   [Refereed]
Tsukamoto M, Sato S, Satake K, Miyake M, Nakagawa H
International journal of molecular sciences   18(7)    Jul 2017   [Refereed]
Toyoda Y, Takada T, Gomi T, Nakagawa H, Ishikawa T, Suzuki H
International journal of molecular sciences   18(2)    Feb 2017   [Refereed]
Sato H, Yoshida M, Murase H, Nakagawa H, Doi T
ACS combinatorial science   18(9) 590-595   Sep 2016   [Refereed]
Fukunaga K, Nakagawa H, Ishikawa T, Kubo M, Mushiroda T
BMC genetics   17(1) 79   Jun 2016   [Refereed]
Efferth T, Banerjee M, Paul NW, Abdelfatah S, Arend J, Elhassan G, Hamdoun S, Hamm R, Hong C, Kadioglu O, Naß J, Ochwangi D, Ooko E, Ozenver N, Saeed ME, Schneider M, Seo EJ, Wu CF, Yan G, Zeino M, Zhao Q, Abu-Darwish MS, Andersch K, Alexie G, Bessarab D, Bhakta-Guha D, Bolzani V, Dapat E, Donenko FV, Efferth M, Greten HJ, Gunatilaka L, Hussein AA, Karadeniz A, Khalid HE, Kuete V, Lee IS, Liu L, Midiwo J, Mora R, Nakagawa H, Ngassapa O, Noysang C, Omosa LK, Roland FH, Shahat AA, Saab A, Saeed EM, Shan L, Titinchi SJ
Phytomedicine : international journal of phytotherapy and phytopharmacology   23(2) 166-173   Feb 2016   [Refereed]
Toyoda Y, Gomi T, Nakagawa H, Nagakura M, Ishikawa T
BioMed research international   2016 7670483   2016   [Refereed]
Yoshida M, Ishida Y, Adachi K, Murase H, Nakagawa H, Doi T
Chemistry (Weinheim an der Bergstrasse, Germany)   21(50) 18417-18430   Dec 2015   [Refereed]
Tajima Y, Murase H, Satake K, Mitani Y, Regasini LO, da Silva Bolzani V, Efferth T, Nakagawa H
Cytotechnology   67(4) 585-592   Aug 2015   [Refereed]
Satake K, Tsukamoto M, Mitani Y, Regasini LO, da Silva Bolzani V, Efferth T, Nakagawa H
Bio-medical materials and engineering   25(3) 249-256   2015   [Refereed]
Tajima Y, Nakagawa H, Tamura A, Kadioglu O, Satake K, Mitani Y, Murase H, Regasini LO, Bolzani Vda S, Ishikawa T, Fricker G, Efferth T
Phytomedicine : international journal of phytotherapy and phytopharmacology   21(3) 323-332   Feb 2014   [Refereed]
Yoshida M, Sato H, Ishida Y, Nakagawa H, Doi T
The Journal of organic chemistry   79(1) 296-306   Jan 2014   [Refereed]
Ishikawa T, Kajimoto Y, Sun W, Nakagawa H, Inoue Y, Ikegami Y, Miyatake S, Kuroiwa T
Journal of pharmaceutical sciences   102(9) 3058-3069   Sep 2013   [Refereed]
Inoue Y, Ikegami Y, Sano K, Suzuki T, Yoshida H, Nakamura Y, Nakagawa H, Ishikawa T
Chemotherapy   59(4) 260-272   2013   [Refereed]
Ishikawa T, Wakabayashi-Nakao K, Nakagawa H
Methods in molecular biology (Clifton, N.J.)   1015 225-250   2013   [Refereed]
Takahashi K, Ikeda N, Nonoguchi N, Kajimoto Y, Miyatake S, Hagiya Y, Ogura S, Nakagawa H, Ishikawa T, Kuroiwa T
Neuro-oncology   13(11) 1234-1243   Nov 2011   [Refereed]
Nakagawa H, Toyoda Y, Wakabayashi-Nakao K, Tamaki H, Osumi M, Ishikawa T
Journal of pharmaceutical sciences   100(9) 3602-3619   Sep 2011   [Refereed]
Wakabayashi-Nakao K, Tamura A, Koshiba S, Toyoda Y, Nakagawa H, Ishikawa T
Methods in molecular biology (Clifton, N.J.)   648 139-159   2010   [Refereed]
Ishikawa T, Nakagawa H, Hagiya Y, Nonoguchi N, Miyatake S, Kuroiwa T
Advances in pharmacological sciences   2010 587306   2010   [Refereed]
Nakagawa H, Wakabayashi-Nakao K, Tamura A, Toyoda Y, Koshiba S, Ishikawa T
The FEBS journal   276(24) 7237-7252   Dec 2009   [Refereed]
Adachi T, Nakagawa H, Hagiya Y, Yasuoka T, Ishikawa T
Molecular pharmaceutics   6(6) 1678-1688   Nov 2009   [Refereed]
Toyoda Y, Sakurai A, Mitani Y, Nakashima M, Yoshiura K, Nakagawa H, Sakai Y, Ota I, Lezhava A, Hayashizaki Y, Niikawa N, Ishikawa T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   23(6) 2001-2013   Jun 2009   [Refereed]
Furukawa T, Wakabayashi K, Tamura A, Nakagawa H, Morishima Y, Osawa Y, Ishikawa T
Pharmaceutical research   26(2) 469-479   Feb 2009   [Refereed]
Wakabayashi-Nakao K, Tamura A, Furukawa T, Nakagawa H, Ishikawa T
Advanced drug delivery reviews   61(1) 66-72   Jan 2009   [Refereed]
Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics.
Ishikawa T, Nakagawa H
Journal of experimental therapeutics & oncology   8(1) 5-24   2009   [Refereed]
Nakagawa H, Tamura A, Wakabayashi K, Hoshijima K, Komada M, Yoshida T, Kometani S, Matsubara T, Mikuriya K, Ishikawa T
The Biochemical journal   411(3) 623-631   May 2008   [Refereed]
Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy.
Hagiya Y, Adachi T, Ogura S, An R, Tamura A, Nakagawa H, Okura I, Mochizuki T, Ishikawa T
Journal of experimental therapeutics & oncology   7(2) 153-167   2008   [Refereed]
Wakabayashi K, Nakagawa H, Tamura A, Koshiba S, Hoshijima K, Komada M, Ishikawa T
The Journal of biological chemistry   282(38) 27841-27846   Sep 2007   [Refereed]
Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress.
Adachi T, Nakagawa H, Chung I, Hagiya Y, Hoshijima K, Noguchi N, Kuo MT, Ishikawa T
Journal of experimental therapeutics & oncology   6(4) 335-348   2007   [Refereed]
Hiroshi Nakagawa, Hasumi, K., Takami, M., Aida-Hyugaji, S., Woo, J. T., Kazuo Nagai, Toshihisa Ishikawa, Masaaki Wachi
Biochem. Pharmacol.   73(1) 34-43   2007   [Refereed]
Theoretical Studies for Molecular Modeling of New Camptothecin Analogues.
Aida-Hyugaji, S., Nakagawa, H., Nomura, J., Sakurai, M., Nagashima, U., Ishikawa, T.
Croat. Chemica. Acta   80 277-281   2007   [Refereed]
Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Kanoh N, Nakagawa H, Takami M, Lee KH, Stern PH, Nagai K, Osada H
Proceedings of the National Academy of Sciences of the United States of America   103(12) 4729-4734   Mar 2006   [Refereed]
Identification of cysteine residues critically involved in homodimer formation and protein expression of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system.
Wakabayashi K, Nakagawa H, Adachi T, Kii I, Kobatake E, Kudo A, Ishikawa T
Journal of experimental therapeutics & oncology   5(3) 205-222   2006   [Refereed]
Cysteine-603 is a critical amino acid forhomodimer formation of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system.
Wakabayashi, K. Nakagawa, H. Adachi, T. Kii, I. Kobatake, E. Kudo, A. Ishikawa, T.
J. Exp. Ther. Oncol.   5 205-222   2006   [Refereed]
Ishikawa, T. Ikegami, Y. Sano, K. Nakagawa, H. Sawada, S.
Curr. Pharm. Des.   12(3) 313-325   2006   [Refereed]
Nakagawa, H. Saito, H. Ikegami, Y. Aida-Hyugaji, S. Sawada, S. Ishikawa, T.
Cancer Lett.   234(1) 81-89   2006   [Refereed]
Saito, H. Hirano, H. Nakagawa, H. Fukami, T. Oosumi, K. Murakami, K. Kimura, H. Kouchi, T. Konomi, M. Tao, E. Tsujikawa, N. Tarui, S. Nagakura, M. Osumi, M. Ishikawa, T.
J. Pharmacol. Exp. Ther.   317(3) 1114-1124   2006   [Refereed]
Hirano, H. Kurata, A. Onishi, Y. Sakurai, A. Saito, H. Nakagawa, H. Nagakura, M. Tarui, S. Kanamori, Y. Kitajima, M. Ishikawa, Y.
Mol. Pharmaceutics   3(3) 252-265   2006   [Refereed]
Genetic Polymorphisms of Human ABC Transporter ABCG2: Development of the Standard Method for Functional Validation of SNPs by using the Flp Recombinase System.
Tamura, A. Wakabayashi, K. Onishi, Y. Nakagawa, H. Tsuji, M. Matsuda, Y. Ishikawa, T.
J. Exp. Ther. Oncol.   6 1-11   2006   [Refereed]
Tamura, A. Watanabe, M. Saito, H. Nakagawa, H. Kamachi, T. Okura, I. Ishikawa, T.
Mol. Pharmacol.   70(1) 287-296   2006   [Refereed]
Woo, JT., Nakagawa, H., Krecic, K.M., Nagai, K., Hamilton, A.D., Sebti, S.M., Stern, P.H.
Biochem Pharmacol.   69(1) 87-95   2005   [Refereed]
Ishikawa, T. Tamura, A. Saito, H. Wakabayashi, K. Nakagawa, H.
Naturwissenschaften   92(10) 451-463   2005   [Refereed]
Takahashi, T. Nakai, K. Doi, T. Yasunaga, M. Nakagawa, H. Ishikawa, T.
Bioorg. Med. Chem. Lett.   15(10) 2601-2605   2005   [Refereed]
Studies on the anti-bone-resorptive mechanism of destruxins and (-)-epigallocatechin-3-gallate
Hiroshi Nakagawa
Tokyo Institute of Technology      Mar 2004   [Refereed]
Nakagawa, H., Hasumi, K., Woo, J.-T., Nagai, K., Wachi, M.
Carcinogenesis   25(9) 1567-1574   2004   [Refereed]
Woo, JT., Nakagawa, H., Notoya, M., Yonezawa, T., Udagawa, N., Lee, IS., Ohnishi, M., Hagiwara, H., Nagai, K.
Biological Pharm. Bull.   27(4) 504-509   2004   [Refereed]
Nakagawa, H., Takami, M., Udagawa, N., Sawae, Y., Suda, K., Sasaki, T., Takahashi, N., Wachi, M., Nagai, K., Woo, JT.
Bone   33(3) 443-455   2003   [Refereed]
Nakagawa, H., Wachi, M., Woo, JT., Kato, M., Kasai, S., Takahashi, F., Lee, IS., Nagai, K.
Biochem. Biophys. Res. Commun.   292(1) 94-101   2002   [Refereed]
Inhibitory effect of destruxins on activation of osteoclasts
Hiroshi Nakagawa
Tokyo Institute of Technology      Mar 2001   [Refereed]
Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance.
Mitani, Y., Satake, K., Tsukamoto, M., Nakamura, I., Kadioglu, O., Teruya, T., Yonezawa, T., Cha, BY., Efferth, T., Woo, JT., and Nakagawa, H.
Phytomedicine   51 112-119   2018   [Refereed]

Books etc

 
Drugs affecting epigenetics of ABC transporters for drug resistance. Thomas E., editor, Resistance to Targeted Anti-Cancer Therapeutics Vol. 4, Resistance to Targeted ABC Transporters in Cancer
Satake, K., Toyoda, Y., and Nakagawa, H. (Part:Joint Work, 273-297)
Springer International Publishing Switzerland   2015   
Progress in Cancer Drug Resistance Research, Transport Mechanism-Based Drug Molecular Design: A New Strategy of High-Speed Screening and Quantitative SAR Analysis of ABC Transport ABCG2 to design Novel Anticancer Drugs.
Saito, H., Hirano, H., Nakagawa, H., Hoshijima, K., and Ishikawa, T. (Part:Joint Work, 43-71)
Nova Publishers   2007   
Multidrug resistance-associated proteins, The GS-X Pumps/Multidrug Resistance Proteins (MRP) Role of Glutathione in Their Function and Gene Regulation. In: Aiello, Christopher V., editor. Multidrug Resistance-associated Proteins.
Ishikawa, T., Nakagawa, H., and Kuo, T.M. (Part:Joint Work, 1-29)
Nova Publishers   2006   

Research Grants & Projects

 
The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2019 - Mar 2022    Investigator(s): NAKAGAWA HIROSHI
Daiichi Sankyo Company: Open Innovation for the Development of Emerging technologies
Project Year: Apr 2018 - Mar 2021    Investigator(s): Kaname Tsutsumiuchi
The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2018 - Mar 2021    Investigator(s): Takeshi Kusunoki
The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2016 - Mar 2019    Investigator(s): Hiroshi Nakagawa
The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Scientific Research (B)
Project Year: Apr 2015 - Mar 2019    Investigator(s): Shinji Yokoyama
Aichi Cancer Research Foundation: Research Grant for Cancer
Project Year: 2017 - Mar 2018    Investigator(s): Hiroshi Nakagawa
The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2015 - Mar 2018    Investigator(s): Takeshi Kusunoki
Aichi Cancer Research Foundation: Research Grant for Cancer
Project Year: 2016 - Mar 2017    Investigator(s): Hiroshi Nakagawa
The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Challenging Exploratory Research
Project Year: Apr 2015 - Mar 2017    Investigator(s): Yu Toyoda
The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Scientific Research (B)
Project Year: Apr 2014 - Mar 2017    Investigator(s): Je-Tae Woo
Aichi Cancer Research Foundation: Research Grant for Cancer
Project Year: 2015 - Mar 2016    Investigator(s): Hiroshi Nakagawa
The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2012 - Mar 2015    Investigator(s): Hiroshi Nakagawa
The Hori Science & Arts Foundation: Research Grant
Project Year: 2014 - Mar 2014    Investigator(s): Hiroshi Nakagawa
Daiko foundation: Research Grant for Science
Project Year: 2013 - Mar 2014    Investigator(s): Je-Tae Woo
Aichi Cancer Research Foundation: Research Grant for Cancer
Project Year: 2013 - Mar 2014    Investigator(s): Hiroshi Nakagawa
Japan Science and Technology Agency: Adaptable and Seamless Technology Transfer Program through Target-driven R&D (A-STEP)
Project Year: 2012 - 2013    Investigator(s): Hiroshi Nakagawa
The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Young Scientists (B)
Project Year: Apr 2010 - Mar 2012    Investigator(s): Hiroshi Nakagawa
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The Japanese Society for the Promotion of Science (JSPS): Grant-in-Aid for Young Scientists (B)
Project Year: Apr 2007 - Mar 2010    Investigator(s): Hiroshi Nakagawa
Japan Science and Technology Agency: Development of advanced measurement and analysis systems
Project Year: 2009 - 2010    Investigator(s): Makoto Nagakura