2007年
Modulation pathways of NCX mRNA stability - Involvement of RhoB
SODIUM-CALCIUM EXCHANGE AND THE PLASMA MEMBRANE CA2+-ATPASE IN CELL FUNCTION: FIFTH INTERNATIONAL CONFERENCE
- ,
- ,
- 巻
- 1099
- 号
- 開始ページ
- 193
- 終了ページ
- 194
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1196/annals.1387.062
- 出版者・発行元
- BLACKWELL PUBLISHING
Cardiac Na+/Ca (2+) exchanger 1 (NCX1) expression levels change under various path op hysiological conditions. However, its mechanism is unknown. We found that fluvastatin, an HMG-CoA reductase inhibitor, decreased NCX1 mRNA and protein by inhibiting a small G protein, RhoB, in H9c2 cardiomyoblasts. Conversely, lysophosphatidylcholine (LPC) increased NCX1 mRNA and protein by activating RhoB. The effect of LPC was mediated by geranylgeranylation but not farnesylation of RhoB. Furthermore, we also detected that activation of RhoB increased NCX1 mRNA stability. Our results suggest that RhoB is involved in modulation of cardiac NCX1 mRNA expression.
- リンク情報
- ID情報
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- DOI : 10.1196/annals.1387.062
- ISSN : 0077-8923
- Web of Science ID : WOS:000245982300022