2004年9月
Forefront of Na+/Ca2+ exchanger studies: Stoichiometry of cardiac Na+/Ca2+ exchanger; 3:1 or 4:1?
Journal of Pharmacological Sciences
- ,
- 巻
- 96
- 号
- 1
- 開始ページ
- 15
- 終了ページ
- 18
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1254/jphs.FMJ04002X3
The stoichiometry of the Na+/Ca2+ exchanger (NCX) had been generally accepted as 3 Na+:1 Ca2+. However, recently a challenging stoichiometry of 4:1 was proposed. Therefore, using guinea pig ventricular cells, we re-examined the stoichiometry by measuring the reversal potential of the NCX current and intracellular Ca2+ concentrations under the whole-cell voltage clamp. We confirmed that the stoichiometry of NCX is 3:1 not 4:1. In addition, we explored the possible reasons for obtaining erroneous results of a 4:1 stoichiometry.
- リンク情報
- ID情報
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- DOI : 10.1254/jphs.FMJ04002X3
- ISSN : 1347-8613
- CiNii Articles ID : 10014166101
- PubMed ID : 15359081
- SCOPUS ID : 4844230631