MISC

2002年

Clinicopathological significance of human macrophage metalloelastase expression in esophageal squamous cell carcinoma

ONCOLOGY
  • YZ Ding
  • Y Shimada
  • MJ Gorrin-Rivas
  • A Itami
  • ZG Li
  • T Hong
  • M Maeda
  • Komoto, I
  • A Kawabe
  • J Kaganoi
  • M Imamura
  • 全て表示

63
4
開始ページ
378
終了ページ
384
記述言語
英語
掲載種別
DOI
10.1159/000066231
出版者・発行元
KARGER

Objective: Human macrophage metalloelastase is referred to as matrix metal loproteinase MMP-12), its function in tumors is contradictory. The current study was undertaken to investigate the role of MMP-12 in esophageal squamous cell carcinoma (SCC).
Patients and Methods: We analyzed the levels of MMP-12 mRNA expression in 67 patients with primary esophageal SCC by Northern blot analysis and the tissues were subjected to in situ hybridization analysis for MMP-12. lmmunohistochemical staining was performed to detect the macrophages infiltrated in esophageal SCCs.
Results: MMP-12 mRNA was detected in 27 of 67 esophageal SCC samples by Northern blot analysis. In situ hybridization and immunohistochemical staining revealed that MMP-12 mRNA signals are located mainly in tumor cells. The frequency of lymph node metastasis was significantly higher in the MMP-12-positive (MMP-12+) subgroup than MMP-12-negative ((MMP-12(-))(-)) subgroup (p < 0.05); furthermore, invasion was significantly deeper in the MMP-12(+) subgroup than in the MMP-12(-) subgroup (p < 0.01). MMP-12 mRNA was inversely correlated with prognosis (p < 0.05). However, Cox multivariate analysis revealed that upregulation of MMP-12 was not related to prognosis.
Conclusions: MMP-12 gene expression was associated with the progression of esophageal SCC; however, it was not an independent prognostic factor.
Copyright (C) 2002 S. Karger AG, Basel.

リンク情報
DOI
https://doi.org/10.1159/000066231
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000179465100009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1159/000066231
  • ISSN : 0030-2414
  • Web of Science ID : WOS:000179465100009

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