SONOSHITA Masahiro

J-GLOBAL         Last updated: Aug 2, 2019 at 20:07
 
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Name
SONOSHITA Masahiro
Affiliation
Hokkaido University
Section
Institute for Genetic Medicine
Degree
(BLANK)(The University of Tokyo), Ph.D(Kyoto University)

Research Areas

 

Education

 
 
 - 
2001
Graduate School, Department of Pharmaceutical Sciences, The University of Tokyo
 
 
 - 
2003
Physiology, Graduate School, Division of Medicine, Kyoto University
 

Published Papers

 
Okada Y, Sonoshita M, Kakizaki F, Aoyama N, Itatani Y, Uegaki M, Sakamoto H, Kobayashi T, Inoue T, Kamba T, Suzuki A, Ogawa O, Taketo MM
Cancer Science   108(4) 744-752   Apr 2017   [Refereed]
Aoyama N, Miyoshi H, Miyachi H, Sonoshita M, Okabe M, Taketo MM
Genes to Cells : devoted to molecular & cellular mechanisms   23(7) 580-589   Jul 2018   [Refereed]
Current Topics Developmental Biology   121 287-309   Jun 2016   [Refereed]
Itatani Y, Sonoshita M, Kakizaki F, Okawa K, Stifani S, Itoh H, Sakai Y, Taketo MM
Journal of Biochemistry   159(1) 133-140   Jan 2016   [Refereed]
Kakizaki F, Sonoshita M, Miyoshi H, Itatani Y, Ito S, Kawada K, Sakai Y, Taketo MM
Cancer Science   107(11) 1622-1631   Nov 2016   [Refereed]
Sonoshita M, Scopton AP, Ung PMU, Murray MA, Silber L, Maldonado AY, Real A, Schlessinger A, Cagan RL, Dar AC
Nature Chemical Biology   14(3) 291-298   Mar 2018   [Refereed]
Sonoshita M, Itatani Y, Kakizaki F, Sakimura K, Terashima T, Katsuyama Y, Sakai Y, Taketo MM
Cancer Discovery   5(2) 198-211   Feb 2015   [Refereed]
Kawada K, Hasegawa S, Murakami T, Itatani Y, Hosogi H, Sonoshita M, Kitamura T, Fujishita T, Iwamoto M, Matsumoto T, Matsusue R, Hida K, Akiyama G, Okoshi K, Yamada M, Kawamura J, Taketo MM, Sakai Y
International Journal of Clinical Oncology   16(5) 464-472   Oct 2011   [Refereed]
Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A, Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura T, Oshima M, Taketo MM
Cancer Cell   19(1) 125-137   Jan 2011   [Refereed]
Fujishita T, Doi Y, Sonoshita M, Hiai H, Oshima M, Huebner K, Croce CM, Taketo MM
British Journal of Cancer   91 1571-1574   Oct 2004   [Refereed]
The fragile histidine triad (FHIT) gene is frequently inactivated in various types of tumours. However, the system-wide pathology caused by FHIT inactivation has not been examined in detail. Here we demonstrate that Fhit gene knockout mice develop...
Kawada K, Sonoshita M, Sakashita H, Takabayashi A, Yamaoka Y, Manabe T, Inaba K, Minato N, Oshima M, Taketo MM
Cancer Research   64(11) 4010-4017   Jun 2004   [Refereed]
Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.
Takeda H, Sonoshita M, Oshima H, Sugihara K, Chulada PC, Langenbach R, Oshima M, Taketo MM
Cancer Research   63(16) 4872-4877   Aug 2003   [Refereed]
Taketo MM, Sonoshita M
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids   1585 72-76   Dec 2002   [Refereed]
Phospolipase A2(PLA2) is the esterase activity that cleaves the sn-2 ester bond in glycerophospholipids, releasing free fatty acids and lysophospholipids. The PLA2activity is found in a variety of enzymes which can be divided in several types base...
Sonoshita M, Takaku K, Oshima M, Sugihara K, Taketo MM
Cancer Research   62 6846-6849   Dec 2002   [Refereed]
Cyclooxygenase-2 (COX-2), the inducible COX isozyme, plays a key role in intestinal tumorigenesis. We have demonstrated recently that COX-2 protein is induced in the polyp stroma near the intestinal luminal surface in the ApcΔ716 mouse, a model fo...
Sonoshita M, Takaku K, Sasaki N, Sugimoto Y, Ushikubi F, Narumiya S, Oshima M, Taketo MM
Nature Medicine   7 1048-1051   Jan 2001   [Refereed]
Arachidonic acid is metabolized to prostaglandin H2(PGH2) by cyclooxygenase (COX). COX-2, the inducible COX isozyme, has a key role in intestinal polyposis. Among the metabolites of PGH2, PGE2is implicated in tumorigenesis because its level is mar...
Takaku K, Sonoshita M, Sasaki N, Uozumi N, Doi Y, Shimizu Y, Taketo MM
Journal of Biological Chemistry   275 34013-34016   Nov 2000   [Refereed]
Arachidonic acid is a precursor for biosynthesis of eicosanoids, including prostaglandins, thromboxanes, leukotrienes, and lipoxins. Cytosolic phospholipase A2(cPLA2) plays a key role in the release of arachidonic acid as the substrate of cyclooxy...

Conference Activities & Talks

 
A whole animal platform to develop novel anti-cancer drugs [Invited]
SONOSHITA Masahiro
Jul 2019   

Research Grants & Projects

 
The analysis of colonic tumorigenesis
Project Year: 2000