2011年1月18日
Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.
Cancer Cell
- 巻
- 19
- 号
- 1
- 開始ページ
- 125
- 終了ページ
- 37
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ccr.2010.11.008
- 出版者・発行元
- CELL PRESS
Metastasis is responsible for most cancer deaths. Here, we show that Aes (or Grg5) gene functions as an endogenous metastasis suppressor. Expression of Aes was decreased in liver metastases compared with primary colon tumors in both mice and humans. Aes inhibited Notch signaling by converting active Rbpj transcription complexes into repression complexes on insoluble nuclear matrix. In tumor cells, Notch signaling was triggered by ligands on adjoining blood vessels, and stimulated transendothelial migration. Genetic depletion of Aes in Apc(Δ716) intestinal polyposis mice caused marked tumor invasion and intravasation that were suppressed by Notch signaling inhibition. These results suggest that inhibition of Notch signaling can be a promising strategy for prevention and treatment of colon cancer metastasis.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.ccr.2010.11.008
- ISSN : 1535-6108
- PubMed ID : 21251616
- Web of Science ID : WOS:000287290300015