MISC

2000年8月

Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression

NATURE CELL BIOLOGY
  • K Usui-Aoki
  • H Ito
  • K Ui-Tei
  • K Takahashi
  • T Lukacsovich
  • W Awano
  • H Nakata
  • ZF Piao
  • EE Nilsson
  • J Tomida
  • D Yamamoto
  • 全て表示

2
8
開始ページ
500
終了ページ
506
記述言語
英語
掲載種別
DOI
10.1038/35019537
出版者・発行元
MACMILLAN PUBLISHERS LTD

The Drosophila fruitless (fru) gene product Fru has been postulated to be a neural sex-determination factor that directs the development of at least two male-specific characteristics, namely courtship behaviour and formation of the muscle of Lawrence (MOL). The fru gene encodes a putative transcription factor with a BTB domain and two zinc-finger motifs, and with consensus Tra-binding sequences. The binding of Tra to these sequences results in sex-specific alternative splicing of the fru mRNA, leading to production of the 'male-type' or 'female-type' Fru protein. We show here that the Fru protein is not detected in the female central nervous system (CNS), despite the similar level of expression of fru mRNA in both male and female CNS. As ectopic expression of both the 'male-type' (with the sequence for the aminoterminal extension) and 'female-type' (without the sequence for the amino-terminal extension) fru cDNA can induce formation of the MOL in females, the presence or absence of the Fru protein, and not its sex-specific structure, seems to be responsible for the sexually dimorphic actions of the fru gene.

リンク情報
DOI
https://doi.org/10.1038/35019537
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000088605000015&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/35019537
  • ISSN : 1465-7392
  • Web of Science ID : WOS:000088605000015

エクスポート
BibTeX RIS