2011年
Generalized vitiligo and associated autoimmune diseases in Japanese patients and their families
Allergology International
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- 巻
- 60
- 号
- 4
- 開始ページ
- 505
- 終了ページ
- 508
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2332/allergolint.11-OA-0303
- 出版者・発行元
- Japanese Society of Allergology
Background: Generalized vitiligo is an acquired disorder in which depigmented macules result from the autoimmune loss of melanocytes from the involved regions of skin. Generalized vitiligo is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases (Hashimoto's thyroiditis and Graves' disease), rheumatoid arthritis, adult-onset type 1 diabetes mellitus, psoriasis, pernicious anemia, systemic lupus erythematosus, and Addison's disease. Methods: One hundred to investigate the occurrence of autoimmune diseases in Japanese patients with generalized vitiligo and their families. Results: Twenty-seven of the patients with generalized vitiligo (20.3%) had autoimmune diseases, particularly autoimmune thyroid disease (sixteen patients, 12%) and alopecia areata (seven patients, 5.3%). Thirty-five patients (26.3%) had a family history of generalized vitiligo and/or other autoimmune diseases. Familial generalized vitiligo was present in fifteen (11.3%), including four families with members affected by autoimmune disorders. Twenty (15.0%) had one or more family members with only autoimmune disorders. Conclusions: Among Japanese vitiligo patients, there is a subgroup with strong evidence of genetically determined susceptibility to not only vitiligo, but also to autoimmune thyroid disease and other autoimmune disorders. © 2011 Japanese Society of Allergology.
- ID情報
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- DOI : 10.2332/allergolint.11-OA-0303
- ISSN : 1440-1592
- ISSN : 1323-8930
- SCOPUS ID : 83455258002