2015年8月
Proposal of inducible skin-associated lymphoid tissue (iSALT)
EXPERIMENTAL DERMATOLOGY
- ,
- 巻
- 24
- 号
- 8
- 開始ページ
- 630
- 終了ページ
- 631
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/exd.12716
- 出版者・発行元
- WILEY-BLACKWELL
In the 1980s, Streilein etal. introduced the term skinassociated lymphoid tissue (SALT)' based on observations that revealed the existence of T cells and dendritic cells (DCs) in the skin and that T cells are activated in the skin draining lymph nodes. However, in the perspective of SALT, it remains still unclear whether and how cellular components in the skin interact with each other. In addition, whether the T-cell activation occurs in the skin insitu has also been unrevealed. With the close observation of a skin specimen obtained from a patient with contact dermatitis, we discovered that dermal DCs (dDCs) clustered and closely attached to T cells. Thus, we hypothesized that this clustering might be essential for the establishment of the dermatitis and the T-cell activation insitu. Through the detailed examination of the elicitation phase of contact hypersensitivity as a murine model of contact dermatitis, we demonstrated the formation of sequential leukocyte clusters at the postcapillary venules. The clusters include perivascular macrophages that are activated by IL-1a produced by keratinocytes and dDCs that are attracted by these macrophages through CXCL2 signalling, both of which are essential for the efficient activation of memory T cells insitu. The structure does not exist in the steady state, but is induced' in response to local inflammatory conditions. Herein, we propose that this structure to be termed as inducible SALT (iSALT)'.
- リンク情報
- ID情報
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- DOI : 10.1111/exd.12716
- ISSN : 0906-6705
- eISSN : 1600-0625
- PubMed ID : 25865042
- Web of Science ID : WOS:000358676000014