MISC

2003年8月

Insulin resistance/beta-cell function and serum ferritin level in non-diabetic patients with hepatitis C virus infection

LIVER INTERNATIONAL
  • M Furutani
  • ,
  • T Nakashima
  • ,
  • Y Sumida
  • ,
  • A Hirohama
  • ,
  • T Yoh
  • ,
  • Y Kakisaka
  • ,
  • H Mitsuyoshi
  • ,
  • H Senmaru
  • ,
  • T Okanoue

23
4
開始ページ
294
終了ページ
299
記述言語
英語
掲載種別
出版者・発行元
BLACKWELL MUNKSGAARD

Background: Since impaired glucose tolerance and iron overload are frequently demonstrated in hepatitis C virus (HCV)-related liver diseases, in this study we investigated insulin resistance, pancreatic beta-cell function, i.e., insulin secretion, and serum ferritin levels in patients with HCV infection, especially non-diabetic patients. Methods: Homeostasis model assessments for insulin resistance (HOMA-IR) and beta-cell function (HOMA-beta) were performed in 92 HCV-infected patients. Results: The levels of plasma immunoreactive insulin (IRI), HOMA-IR, and HOMA-beta were significantly correlated with fasting plasma glucose (FPG) levels. Among the 86 non-diabetics (with an FPG of <126 mg/dl), IRI, HOMA-IR, and HOMA-beta were significantly higher in patients with liver cirrhosis than in patients with persistently normal alanine aminotransferase levels. The IRI and HOMA-IR values, but not the HOMA-beta values, were correlated with both serum transaminase and ferritin levels in the 65 non-diabetic chronic hepatitis patients. Conclusion: Insulin resistance was connected with impaired glucose tolerance and the severity of liver diseases in non-diabetic patients with HCV infection. Iron overload may be responsible for insulin resistance, or vice versa. Pancreatic beta-cell function was unrelated to the patients' serum ferritin levels.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000184484800012&DestApp=WOS_CPL
ID情報
  • ISSN : 1478-3231
  • Web of Science ID : WOS:000184484800012

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