澤田秀幸 (Hideyuki Sawada) - マイポータル

基本情報

所属: 独立行政法人国立病院機構宇多野病院臨床研究部副院長

学位: 京都大学博士（医学）(京都大学)

J-GLOBAL ID: 200901002985649503
researchmap会員ID: 1000327554

外部リンク: http://www.hosp.go.jp/9,458,30.html

研究キーワード

研究分野

ライフサイエンス / 神経内科学 /

経歴

2016年1月 - 現在

国立病院機構宇多野病院, 副院長
2005年6月 - 2015年12月

国立病院機構宇多野病院, 臨床研究部長
2000年 - 2005年

京都大学助手
2000年 - 2005年

Kyoto University Hospital, Assistant Professor
1997年 - 2000年

京都大学医学部付属病院医員
1997年 - 2000年

Kyoto University Hospital, clinical fellow

学歴

委員歴

受賞

2002年

第2回パーキンソン病フォーラムベストポスター賞

論文

Oxybuprocaine for apraxia of lid opening in Parkinson's disease: A placebo-controlled pilot trial

Masayuki Kohsaka, Tomoko Oeda, Atsushi Umemura, Satoshi Tomita, Kwiyoung Park, Kenji Yamamoto, Hiroshi Sugiyama, Hideyuki Sawada

Movement Disorders 33(3) 494-495 2018年3月査読有り
Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis

Hideyuki Sawada

EXPERT OPINION ON PHARMACOTHERAPY 18(7) 735-738 2017年5月査読有り
メチシリン耐性コアグラーゼ陰性ブドウ球菌による感染性心内膜炎にくも膜下出血を合併した1例

Kajikawa S, Oeda T, Park K, Yamamoto K, Sugiyama H, Sawada H

Rinsho shinkeigaku = Clinical neurology 57(12) 775-777 2017年査読有り
Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease

Tomoko Oeda, Atsushi Umemura, Yuko Mori, Satoshi Tomita, Masayuki Kohsaka, Kwiyoung Park, Kimiko Inoue, Harutoshi Fujimura, Hiroshi Hasegawa, Hiroshi Sugiyama, Hideyuki Sawada

NEUROBIOLOGY OF AGING 36(12) 3306-3313 2015年12月査読有り
Impact of Aspiration Pneumonia on the Clinical Course of Progressive Supranuclear Palsy: A Retrospective Cohort Study

Satoshi Tomita, Tomoko Oeda, Atsushi Umemura, Masayuki Kohsaka, Kwiyoung Park, Kenji Yamamoto, Hiroshi Sugiyama, Chiaki Mori, Kimiko Inoue, Harutoshi Fujimura, Hideyuki Sawada

PLOS ONE 10(8) e0135823 2015年8月査読有り
Baseline Plasma C-Reactive Protein Concentrations and Motor Prognosis in Parkinson Disease

Atsushi Umemura, Tomoko Oeda, Kenji Yamamoto, Satoshi Tomita, Masayuki Kohsaka, Kwiyoung Park, Hiroshi Sugiyama, Hideyuki Sawada

PLOS ONE 10(8) e0136722 2015年8月査読有り
Baseline C-Reactive Protein Levels and Life Prognosis in Parkinson Disease

Hideyuki Sawada, Tomoko Oeda, Atsushi Umemura, Satoshi Tomita, Masayuki Kohsaka, Kwiyoung Park, Kenji Yamamoto, Hiroshi Sugiyama

PLOS ONE 10(7) e0134118 2015年7月査読有り
A case of refractory generalized myasthenia gravis with anti-acetylcholine receptor antibodies treated with rituximab

Ryutaro Hayashi, Masayuki Tahara, Tomoko Oeda, Tetsuro Konishi, Hideyuki Sawada

Clinical Neurology 55(4) 227-232 2015年査読有り
Delirium and High Fever Are Associated with Subacute Motor Deterioration in Parkinson Disease: A Nested Case-Control Study

Atsushi Umemura, Tomoko Oeda, Satoshi Tomita, Ryutaro Hayashi, Masayuki Kohsaka, Kwiyoung Park, Hiroshi Sugiyama, Hideyuki Sawada

PLOS ONE 9(6) e94944 2014年6月査読有り
Rates of Serious Intracellular Infections in Autoimmune Disease Patients Receiving Initial Glucocorticoid Therapy

Kiyoshi Migita, Toru Arai, Naoki Ishizuka, Yuka Jiuchi, Yasuharu Sasaki, Yasumori Izumi, Tetsuyuki Kiyokawa, Eiichi Suematsu, Tomoya Miyamura, Hiroshi Tsutani, Yojiro Kawabe, Ryutaro Matsumura, Shunsuke Mori, Shiro Ohshima, Shigeru Yoshizawa, Kenji Kawakami, Yasuo Suenaga, Hideo Nishimura, Toyohiko Sugimoto, Hiroaki Iwase, Hideyuki Sawada, Haruhiro Yamashita, Shigeyuki Kuratsu, Fumitaka Ogushi, Masaharu Kawabata, Toshihiro Matsui, Hiroshi Furukawa, Seiji Bito, Shigeto Tohma

PLOS ONE 8(11) e78699 2013年11月査読有り
Trigger medications and patient-related risk factors for Parkinson disease psychosis requiring anti-psychotic drugs: a retrospective cohort study

Hideyuki Sawada, Tomoko Oeda, Kenji Yamamoto, Atsushi Umemura, Satoshi Tomita, Ryutaro Hayashi, Masayuki Kohsaka, Takashi Kawamura

BMC NEUROLOGY 13 145 2013年10月査読有り
Clinical Factors Associated with Abnormal Postures in Parkinson's Disease

Tomoko Oeda, Atsushi Umemura, Satoshi Tomita, Ryutaro Hayashi, Masayuki Kohsaka, Hideyuki Sawada

PLOS ONE 8(9) e73547 2013年9月査読有り
Protocol for a randomised controlled trial: efficacy of donepezil against psychosis in Parkinson's disease (EDAP).

Sawada H, Oeda T

BMJ open 3 e003533 2013年9月査読有り
Diagnostic Accuracy of Apparent Diffusion Coefficient and 123I-Metaiodobenzylguanidine for Differentiation of Multiple System Atrophy and Parkinson’s Disease

Umemura A, Oeda T, Hayashi R, Tomita S, Kohsaka M, Yamamoto K, Sawada H

PLOS One 8(4) e61066 2013年4月査読有り
Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein

Sawada H, Oeda T, Yamamoto K

Diagnostics 3(2) 210-221 2013年3月25日査読有り招待有り
Amantadine for Dyskinesias in Parkinson's Disease: A Randomized Controlled Trial

Hideyuki Sawada, Tomoko Oeda, Sadako Kuno, Masahiro Nomoto, Kenji Yamamoto, Mitsutoshi Yamamoto, Kinya Hisanaga, Takashi Kawamura

PLOS ONE 5(12) e15298 2010年12月査読有り
Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat rnesencephalic cultures

Takaaki Matsuo, Yasuhiko Izumi, Toshiaki Kume, Yuki Takada-Takatori, Hideyuki Sawada, Akinori Akaike

NEUROSCIENCE LETTERS 481(2) 78-81 2010年9月査読有り
Reconstruction and quantitative evaluation of dopaminergic innervation of striatal neurons in dissociated primary cultures

Seiko Wakita, Yasuhiko Izumi, Takaaki Matsuo, Toshiaki Kume, Yuki Takada-Takatori, Hideyuki Sawada, Akinori Akaike

JOURNAL OF NEUROSCIENCE METHODS 192(1) 83-89 2010年9月査読有り
Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures: Implication of inhibition of vesicular transport

Takaaki Matsuo, Yasuhiko Izumi, Seiko Wakita, Toshiaki Kume, Yuki Takada-Takatori, Hideyuki Sawada, Akinori Akaike

EUROPEAN JOURNAL OF PHARMACOLOGY 640(1-3) 68-74 2010年8月査読有り
Elevation of Heme Oxygenase-1 by Proteasome Inhibition Affords Dopaminergic Neuroprotection

Noriyuki Yamamoto, Yasuhiko Izumi, Takaaki Matsuo, Seiko Wakita, Toshiaki Kume, Yuki Takada-Takatori, Hideyuki Sawada, Akinori Akaike

JOURNAL OF NEUROSCIENCE RESEARCH 88(9) 1934-1942 2010年7月査読有り

もっとみる

MISC

Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells

Kentaro Yamakawa, Yasuhiko Izumi, Hiroki Takeuchi, Noriyuki Yamamoto, Toshiaki Kume, Akinori Akaike, Ryosuke Takahashi, Shun Shimohama, Hideyuki Sawada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 391(1) 129-134 2010年1月
Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation

Yasuhiko Izumi, Noriyuki Yamamoto, Takaaki Matsuo, Seiko Wakita, Hiroki Takeuchi, Toshiaki Kume, Hiroshi Katsuki, Hideyuki Sawada, Akinori Akaike

JOURNAL OF NEUROCHEMISTRY 110(2) 745-755 2009年7月
Nicotinic Receptor Stimulation Protects Nigral Dopaminergic Neurons in Rotenone-induced Parkinson's Disease Models

Hiroki Takeuchi, Takashi Yanagida, Masatoshi Inden, Kazuyuki Takata, Yoshihisa Kitamura, Kentaro Yamakawa, Hideyuki Sawada, Yasuhiko Izumi, Noriyuki Yamamoto, Takeshi Kihara, Kengo Uemura, Haruhisa Inoue, Takashi Taniguchi, Akinori Akaike, Ryosuke Takahashi, Shun Shimohama

JOURNAL OF NEUROSCIENCE RESEARCH 87(2) 576-585 2009年2月
High risk factors for valvular heart disease from dopamine agonists in patients with Parkinson's disease

Tomoko Oeda, Motoko Masaki, Kenji Yamamoto, Eiji Mizuta, Naoyuki Kitagawa, Tsuyoshi Isono, Satoshi Taniguchi, Kiyoshi Doi, Hitoshi Yaku, Chikao Yutani, Takashi Kawamura, Sadako Kuno, Hideyuki Sawada

JOURNAL OF NEURAL TRANSMISSION 116(2) 171-178 2009年2月
Diagnostic accuracy of cardiac metaiodobenzylguanidine (MIBG) scintigraphy in Parkinson disease

Sawada H, Oeda T, Yamamoto K, Kitagawa N, Hosokawa R, Ohba M, Nishio R, Yamakawa K, Takeuchi H, Shimohama S, Takahashi R, Kawamura T

Eur J Neruol 16(2) 174-182 2009年
Regulation of intracellular dopamine levels by dopaminergic drugs: Involvement of vesicular monoamine transporter

Yasuhiko Izumi, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Hideyuki Sawada, Akinori Akaike

EUROPEAN JOURNAL OF PHARMACOLOGY 582(1-3) 52-61 2008年3月
Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity

Yasuhiko Izumi, Hideyuki Sawada, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinorl Akaike

EUROPEAN JOURNAL OF PHARMACOLOGY 557(2-3) 132-140 2007年2月
Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress - Relevance to Parkinson disease

Noriyuki Yamamoto, Hideyuki Sawada, Yasuhiko Izumi, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaike

JOURNAL OF BIOLOGICAL CHEMISTRY 282(7) 4364-4372 2007年2月
Altered plasticity of the human motor cortex in Parkinson's disease

Y Ueki, T Mima, M Ali Kotb, H Sawada, H Saiki, A Ikeda, T Begum, F Reza, T Nagamine, H Fukuyama

ANNALS OF NEUROLOGY 59(1) 60-71 2006年1月
Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia

Masafumi Ihara, Fumi Makino, Hideyuki Sawada, Takahiro Mezaki, Kotaro Mizutani, Hiroshi Nakase, Makoto Matsui, Hidekazu Tomimoto, Shun Shimohama

INTERNAL MEDICINE 45(3) 135-140 2006年
Rapid recovery from coma with multifocal PLEDs in a patient with severe dementia and transient hypoxemia

Tahamina Begum, Akio Ikeda, Atsuko Yoshioka, Hideyuki Sawada, Hidenao Fukuyama, Hiroshi Shibasaki

INTERNAL MEDICINE 45(13) 823-826 2006年
Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells

Y Izumi, H Sawada, N Yamamoto, T Kume, H Katsuki, S Shimohama, A Akaike

JOURNAL OF NEUROSCIENCE RESEARCH 82(1) 126-137 2005年10月
Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons

T Kume, Y Kawai, K Yoshida, T Nakamizo, R Kanki, H Sawada, H Katsuki, S Shimohama, H Sugimoto, A Akaike

NEUROSCIENCE LETTERS 383(3) 199-202 2005年8月
Stimulation of nicotinic acetylcholine receptors protects motor neurons

T Nakamizo, J Kawamata, H Yamashita, R Kanki, T Kihara, H Sawada, A Akaike, S Shimohama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330(4) 1285-1289 2005年5月
p-quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly

Y Izumi, H Sawada, N Sakka, N Yamamoto, T Kume, H Katsuki, S Shimohama, A Akaike

JOURNAL OF NEUROSCIENCE RESEARCH 79(6) 849-860 2005年3月
Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats

Inden M, Kondo J, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S

J Pharmacol Sci 97(2) 203-211 2005年
Cocaine and phenylephrine eye drop test for Parkinson disease

Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T, Shimohama S

JAMA 293(8) 932-934 2005年
Galantamine modulates nicotinic receptor and blocks A beta-enhanced glutamate toxicity

T Kihara, H Sawada, T Nakamizo, R Kanki, H Yamashita, A Maelicke, S Shimohama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 325(3) 976-982 2004年12月
Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons

R Kanki, T Nakamizo, H Yamashita, T Kihara, H Sawada, K Uemura, J Kawamata, H Shibasaki, A Akaike, S Shimohama

BRAIN RESEARCH 1015(1-2) 73-81 2004年7月
BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line

R Kohno, H Sawada, Y Kawamoto, K Uemura, H Shibasaki, S Shimohama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 318(1) 113-118 2004年5月

もっとみる

講演・口頭発表等

Risk factors for psychosis in Parkinson's disease

3rd International Symposium on Dopaminergic and Nondopaminergic Mechanisms in Parkinson's Disease 2007年
Cardiac metaiodobenzylguanidine scintigraphy as a peripheral bimarker for the diagnosis of Parkinson's disease

XVII WFN World Congress on Parkinson's Disease and Related Disorders 2007年
Cardiac metaiodobenzylguanidine (MIBG) scintigraphy as a peripheral bimarker for the diagnosis of Parkinson's disease

5th Congress of the International Society for Autonomic Neuroscience 2007年
Risk factors for psychosis in Parkinson disease

17th WFN World Congress on Parkinson’s disease and Related Disorders 2007年

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

パーキンソン病におけるジスキネジアに対するアマンタジンの有効性検証

委託研究 2007年 - 2008年
パーキンソン病における神経細胞死
Neuronal death in Parkinson's olisease

産業財産権

パーキンソン病診断キット