DEGUCHI Yoshiharu


DEGUCHI Yoshiharu

J-GLOBAL         Last updated: Sep 28, 2019 at 19:15
 
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Name
DEGUCHI Yoshiharu
Affiliation
Teikyo University
Section
Faculty of Pharmaceutical Sciences, Drug Disposition and Pharmacokinetics
Job title
Associate Professor
Degree
Ph. D.(Kanazawa University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2005
 - 
Today
Professor, Faculty of Pharma Sciences, Teiko University
 
Apr 2000
 - 
Mar 2002
Assistant Professor, Hokkaido Colledge of Pharmacy
 

Education

 
Jan 1997
 - 
Mar 1997
Post Doc Fellow in Medicine, UCLA School of Medicine
 
 
 - 
1982
Graduate School, Division of Pharmaceutical Sciences, Kanazawa University
 
 
 - 
1980
Faculty of Pharmaceutical Science, Kanazawa University
 

Committee Memberships

 
 
 - 
Today
Associate Editor of Biological Pharmaceutical Bulletin  The Pharmaceutical Society of Japan
 
 
 - 
Today
Editorial Advisory Board of Journal of Pharmaceutical Sciences  The Japanese Society of the Study of Xenobiotics
 
 
 - 
Today
Associate Editor of Drug Metabolism and Pharmacokinetics  The Japanese Society for the Study of Xenobiotics
 
 
 - 
Today
Editorial Board  Fluids and Barriers of the CNS
 

Awards & Honors

 
Dec 2014
Top Reviewers of J. Pharm. Sci., American Pharmacist Association
 
Mar 2009
Top Reviewer of J. Pharm. Sci., American Pharmacist Association
 
2001
The Encouraging Prize of Japanese Society for the Study of Xenobiotics
 

Published Papers

 
Kurosawa T, Tega Y, Higuchi K, Yamaguchi T, Nakakura T, Mochizuki T, Kusuhara H, Kawabata K, Deguchi Y
Molecular pharmaceutics      Nov 2018   [Refereed]
Takahashi Y, Nishimura T, Higuchi K, Noguchi S, Tega Y, Kurosawa T, Deguchi Y, Tomi M
Pharmaceutical research   35(12) 246   Oct 2018   [Refereed]
Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi Y, Arata M, Ito A, Yoshida M, Nagaoka Y, Sumiyoshi T
ACS medicinal chemistry letters   9(9) 884-888   Sep 2018   [Refereed]
Nakamura Y, Nakanishi T, Shimada H, Shimizu J, Aotani R, Maruyama S, Higuchi K, Okura T, Deguchi Y, Tamai I
The Journal of neuroscience : the official journal of the Society for Neuroscience   38(24) 5584-5595   Jun 2018   [Refereed]
Nakanishi T, Tamai I, Deguchi Y
Biological & pharmaceutical bulletin   41(9) 1322-1323   2018   [Refereed]
Kurosawa T, Higuchi K, Okura T, Kobayashi K, Kusuhara H, Deguchi Y
Journal of pharmaceutical sciences   106(9) 2576-2582   Sep 2017   [Refereed]
Usui T, Nakazawa A, Okura T, Deguchi Y, Akanuma SI, Kubo Y, Hosoya KI
Journal of neurochemistry   139(3) 408-418   Nov 2016   [Refereed]
Kitamura A, Okura T, Higuchi K, Deguchi Y
Journal of pharmaceutical sciences   105(2) 935-940   Feb 2016   [Refereed]
Higuchi K, Kitamura A, Okura T, Deguchi Y
Drug metabolism and pharmacokinetics   30(2) 182-187   Apr 2015   [Refereed]
Okura T, Higuchi K, Deguchi Y
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   135(5) 697-702   2015   [Refereed]
Kitamura A, Higuchi K, Okura T, Deguchi Y
Journal of pharmaceutical sciences      Aug 2014   [Refereed]
Okura T, Higuchi K, Kitamura A, Deguchi Y
Biological & pharmaceutical bulletin   37 286-291   2014   [Refereed]
Yoshida A, Kuraoka S, Ito Y, Okura T, Deguchi Y, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Yamada S
Journal of pharmacological sciences   124 40-46   2014   [Refereed]
Osano A, Yokoyama Y, Hayashi H, Itoh K, Okura T, Deguchi Y, Ito Y, Yamada S
Journal of pharmacological sciences   124 86-91   2014   [Refereed]
Yokoyama Y, Osano A, Hayashi H, Itoh K, Okura T, Deguchi Y, Ito Y, Yamada S
Biological & pharmaceutical bulletin   37 461-465   2014   [Refereed]
Tomioka NH, Nakamura M, Doshi M, Deguchi Y, Ichida K, Morisaki T, Hosoyamada M
Fluids and barriers of the CNS   10 31   Oct 2013   [Refereed]
Fujii S, Hayashi H, Itoh K, Yamada S, Deguchi Y, Kawazu K
The Journal of pharmacy and pharmacology   65 171-180   Feb 2013   [Refereed]
Shimomura K, Okura T, Kato S, Couraud PO, Schermann JM, Terasaki T, Deguchi Y
Fluids and barriers of the CNS   10 8   Jan 2013   [Refereed]
Sadiq MW, Borgs A, Okura T, Shimomura K, Kato S, Deguchi Y, Jansson B, Björkman S, Terasaki T, Hammarlund-Udenaes M
Journal of pharmaceutical sciences   100(9) 3912-3923   Sep 2011   [Refereed]
Okura T, Kato S, Takano Y, Sato T, Yamashita A, Morimoto R, Ohtsuki S, Terasaki T, Deguchi Y
Journal of pharmaceutical sciences   100 3924-3938   Sep 2011   [Refereed]
Deguchi Y
Drug metabolism and pharmacokinetics   26(3) 219   2011   [Refereed]
Maeda Y, Araki Y, Uno T, Yoshida A, Nishigaki K, Inaba N, Hayashi H, and Deguchi Y.
Journal of Rural Medicine   6(1) 9-15   2011   [Refereed]
The blood-brain barrier as a focus of drug metabolism and pharmacokinetics
Deguchi Y
Drug Metabolism and Pharmacokinetics   26 1-1   2011   [Refereed]
Nakazawa Y, Okura T, Shimomura K, Terasaki T, Deguchi Y
Journal of pharmaceutical sciences   99(1) 467-474   Jan 2010   [Refereed]
Kato S, Kato Y, Nakamura T, Sugiura T, Kubo Y, Deguchi Y, Tsuji A
Biopharmaceutics & drug disposition   30(9) 495-507   Dec 2009   [Refereed]
Okura T, Hattori A, Takano Y, Sato T, Hammarlund-Udenaes M, Terasaki T, Deguchi Y
Drug metabolism and disposition: the biological fate of chemicals   36(10) 2005-2013   Oct 2008   [Refereed]
Okura T, Ito R, Ishiguro N, Tamai I, Deguchi Y
Life sciences   80(17) 1564-1571   Apr 2007   [Refereed]
Okura T, Komiyama N, Morita Y, Kimura M, Deguchi Y, Yamada S
Life sciences   80(14) 1319-1326   Mar 2007   [Refereed]
Sun J, Deguchi Y, Tauchi Y, He Z, Cheng G, Morimoto K
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V   64(2) 238-245   Oct 2006   [Refereed]
Chono S, Tauchi Y, Deguchi Y, Morimoto K
Journal of drug targeting   13(4) 267-276   May 2005   [Refereed]
Characterization of the blood-brain barrier transport of promipexole, a dopamine D2 agonist.
Okura T, Ito R, Ishiguro N, Igarashi T, Tamai I and Deguchi Y.
Drug Metabolism Review of Biotransformation and Disposition of Xenobiotics   37(suppl 2) 179   2005   [Refereed]
Blood-Brain Barrier Transport and Neuroprotective Effect of a novel cationic VIP analogue.
Deguchi Y, Okura T, Yamaguchi T, Takeda N, Ito R and Watanabe Y.
Drug Metabolism Review of Biotransformation and Disposision of Xenobiotics   37(supp 2) 273   2005   [Refereed]
Deguchi Y, Naito Y, Ohtsuki S, Miyakawa Y, Morimoto K, Hosoya K, Sakurada S, Terasaki T
The Journal of pharmacology and experimental therapeutics   310 177-184   Jul 2004   [Refereed]
Makino T, Wakushima H, Okamoto T, Okukubo Y, Deguchi Y, Kano Y
Phytotherapy research : PTR   17 1021-1024   Nov 2003   [Refereed]
Sun J, Sakai S, Tauchi Y, Deguchi Y, Cheng G, Chen J, Morimoto K
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V   56 223-229   Sep 2003   [Refereed]
Urayama A, Yamada S, Deguchi Y, Ohmori Y, Kimura R
The Journal of pharmacy and pharmacology   55 603-608   May 2003   [Refereed]
Deguchi Y, Miyakawa Y, Sakurada S, Naito Y, Morimoto K, Ohtsuki S, Hosoya K, Terasaki T
Journal of Neurochemistry   84 1154-1161   Mar 2003   [Refereed]
Urayama A, Yamada S, Ohmori Y, Deguchi Y, Uchida S, Kimura R
Drug metabolism and pharmacokinetics   18 310-318   2003   [Refereed]
Deguchi Y, Sun J, Tauchi Y, Sakai S, Morimoto K
Drug metabolism and pharmacokinetics   18 319-326   2003   [Refereed]
Deguchi Y, Okutsu H, Okura T, Yamada S, Kimura R, Yuge T, Furukawa A, Morimoto K, Tachikawa M, Ohtsuki S, Hosoya K, Terasaki T
Journal of Neurochemistry   83 381-389   Oct 2002   [Refereed]
Makino T, Wakushima H, Okamoto T, Okukubo Y, Deguchi Y, Kano Y
Journal of ethnopharmacology   82 35-40   Sep 2002   [Refereed]
Sun J, Sakai S, Tauchi Y, Deguchi Y, Chen J, Zhang R, Morimoto K
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V   54 51-58   Jul 2002   [Refereed]
Interactions between quinolone antibiotics and phospholipid membrane for prediction of alveolar macrophage uptake in vitro.
Sun J, Deguchi Y, Chen JM, Zhang RH, Morimoto K
Acta pharmacologica Sinica   23 430-438   May 2002   [Refereed]
Wang J, Sakai S, Deguchi Y, Bi D, Tabata Y, Morimoto K
The Journal of pharmacy and pharmacology   54 181-188   Feb 2002   [Refereed]
Deguchi Y
Drug metabolism and pharmacokinetics   17 395-407   2002   [Refereed]
Deguchi Y, Morimoto K and Terasaki T.
SEITAI NO KAGAKU.   52(6) 563-570   Nov 2001   [Refereed][Invited]
DEGUCHI Yoshiharu, OKUTSU Hiroshi, NAITO Takafumi, OKURA Takashi, YAMADA Shizuo, YUGE Takuro, FURUKAWA Akihiko, OHTSUKI Sumio, HOSOYA Ken-ichi, TERASAKI Tetsuya, MORIMOTO Kazuhiro, KIMURA Ryohei
Drug Metabolism and Pharmacokinetics   16(2) 140-144   2001
The purpose of the present study was to characterize the transport mechanism of basic fibroblast growth factor (bFGF) through the blood-brain barrier (BBB). Following internal carotid artery perfusion, 125I-bFGF was transcytosed through...
Development of drug delivery system for atherosclerotic therapy using dexamethasone incorporated into liposomes.
Chono S, Tauchi Y, Deguchi Y and Morimoto K.
Progress in Drug Dlivery System   10 1-11   2001   [Refereed]
Urayama A, Yamada S, Hirano K, Deguchi Y and Kimura R.
Life Sciences   70 647-657   2001   [Refereed]
Deguchi Y, Naito T, Yuge T, Furukawa A, Yamada S, Pardridge WM, and Kimura R.
Pharmaceutical Research   17 63-69   2000   [Refereed]
Deguchi Y, Yokoyama Y, Sakamoto T, Hayashi H, Naito T, Yamada S and Kimura R.
Life Siences   66 649-662   2000   [Refereed]
Uchida S, Yamada S, Deguchi Y, Yamamoto M and Kimura R.
Pharmaceutical Research   17 844-850   2000   [Refereed]
Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori.
Wang J, Tauchi Y, Deguchi Y, Morimoto K, Tabata Y and Ikada Y.
Drug Delivery   7 237-243   2000   [Refereed]
Disposition and α1-adrenoceptor binding characteristics of JHT-601 and its metabolites in rat tissues.
Yamada S, Okura T, Kimura R, Deguchi Y, Suzuki Y, Kobayashi T and Aisaka K.
Drug Metabolism and Disposition   28 1487-1492   2000   [Refereed]
Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: a preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer’s disease.
Deguchi Y, Hayashi H, Fujii S, Naito T, Yokoyama Y, Yamada S and Kimura R
Journal of Drug Targeting   8 371-381   2000   [Refereed]
Ohkura T, Yamada S, Deguchi Y, and Kimura R.
Biological and Pharmaceutical Bulletin   22 412-417   1999   [Refereed]
In vivo measurement by [3H]tamuslosin of α-adrenoceptors in rat tissues in relation to the pharmacokinetics.
Yamada S, Ohkura T, Deguchi Y, and Kimura R.
Journal of Pharmacology and Experimental Therapeutics   289 1575-1583   1999   [Refereed]
Urayama A, Yamada S, Deguchi Y, Kimura R, Maeda Y, and Kobayashi T.
Life Sciences   65 2407-2415   1999   [Refereed]
Study on the blood-brain barrier transport of human basic fibroblast growth factor.
Deguchi Y, Naito T, Yuge T, Wakao A, Kato Y, Yamada S and Kimura R.
Progress in Drug Dlivery System   7 61-69   1998   [Refereed]
An attempt to develop new CNS pharmaceuticals against Alzheimer’s disease. Improvement of brain delivery of nonsteroidal antiinflammatory drugs (NSAIDs) by its lipophilic prodrug.
Hayashi H, Deguchi Y, Tanaka M, Yokoyama Y, Yamada S and Kimura R.
Progress in Drug Dlivery System   6 53-61   1997   [Refereed]
Ohkura T, Yamada S, Deguchi Y, Kimura R, Matsushima H, Higuchi S, Inagaki O, Honda K, and Takenaka T.
Life Sciences   63 2147-2155   1998   [Refereed]
Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: Possible involvement of the monocarboxylic acid transport system.
Deguchi Y, Nozawa K, Yamada S, Yokoyama Y, and Kimura R.
Journal of Pharmacology and Experimental Therapeutics   280 551-560   1997   [Refereed]
Uchida S, Yamada S, Nagai K, Deguchi Y, and Kimura R.
Life Sciences   61 2083-2090   1997   [Refereed]
Pharmacokinetics of a third-generation dihydropyridine calcium antagonist, amlodipine and its occupation of cardiovacular receptors.
Yamada S, Uchida S, Okura T, Sugimoto N, Deguchi Y, and Kimura R.
Japanese Pharmacology and Therapeutics   23 75-86   1995   [Refereed]
Deguchi Y, Inabe K, Tomiyasu K, Nozawa K, Yamada S, and Kimura R.
Pharmaceutical Research   12 1838-1844   1995   [Refereed]
Uchida S, Yamada S, Sugimoto N, Deguchi Y, and Kimura R.
Japanese Heart Journal   35 SHR(29)   1994   [Refereed]
Pharmacokinetics of amlodipine and its occupancy of calcium antagonist receptors.
Yamada S, Sugimoto N, Uchida S, Deguchi Y, and Kimura R.
Journal of Cardiovascular Pharmacology   23 466-472   1994   [Refereed]
Sakata A, Tamai I, Kawazu K, Deguchi Y, Ohnishi T, Saheki A and Tsuji A.
Biochemical Pharmacology   48 1989-1992   1994   [Refereed]
Shimura T, Tabata S, Matsumoto T, Kondo S, Tsuda S, Deguchi Y, Terasaki T, and Tsuji A.
Annals of New York Academy of Sciences   680 609-611   1993   [Refereed]
Terasaki T, Deguchi Y, Kasama Y, Pardridge WM, and Tsuji A.
International Journal of Pharmaceutics   81 143-152   1992   [Refereed]
Shimura T, Tabata S, Terasaki T, Deguchi Y, and Tsuji A.
Journal of Pharmacy and Pharmacology   44 583-588   1992   [Refereed]
Terasaki T, Deguchi Y, Kawasaki S, Kasama Y and Tsuji A.
Journal of Pharmacobio-Dynamics   14 s-58   1991   [Refereed]
Terasaki T, Deguchi Y, Sato H, Hirai K, and Tsuji A.
Pharmaceutical Research   8 815-820   1991   [Refereed]
Deguchi Y, Terasaki T, Kawasaki S, and Tsuji A.
Journal of Pharmacobio-Dynamics   14 483-492   1991   [Refereed]
Ichimura F, Matsushita R, Tsuji A, and Deguchi Y.
Journal of Pharmaceutical Sciences   79 1041-1042   1990   [Refereed]
Effects of palmitic acid on human serum albumin binding interaction between phenytoin and valproate in vitro.
Matsushita R, Deguchi Y, Yokogawa K, Nakashima E, and Ichimura F.
YAKUZAIGAKU (in japanese)   49 221-226   1989   [Refereed]
Nakashima E, Ishikawa F, Sato H, Deguchi Y, Tamai I, Matsushita R, Ichimura F, and Tsuji A.
Journal of Pharmaceutical Sciences   77 481-488   1988   [Refereed]
Deguchi Y, Nakashima E, Ishikawa F, Sato H, Tamai I, Matsushita R, Tofuku Y, Ichimura F, and Tsuji A.
Journal of Pharmaceutical Sciences   77 559-564   1988   [Refereed]
Sato H, Ishikawa F, Okezaki E, Nagata O, Nakashima E, Deguchi Y, Ichimura F, and Tsuji A.
Chemal and Pharmaceutical Bulletin   36 3180-3185   1988   [Refereed]
Deguchi Y, Koshida R, Nakashima E, Watanabe R, Taniguchi N, Ichimura F, and Tsuji A.
Journal of Pharmaceutical Sciences   77 674-678   1988   [Refereed]
Ichimura F, Deguchi Y, Yokogawa K, and Nakashima E.
Chemical and Pharmaceutical Bulletin   35 2030-2037   1987   [Refereed]
Ichimura F, Deguchi Y, Yokogawa K and Yamana T.
International Journal of Pharmaceutics   27 45-60   1985   [Refereed]
Tsuji A, Nakashima E, Nishide K, Deguchi Y, Hamano S, and Yamana T.
Chemical and Pharmaceutical Bulletin   31 4057-4069   1983   [Refereed]
Tsuji A, Nakashima E, Deguchi Y, Nishide K, Shimizu T, Horiuchi S, Ishikawa K, and Yamana T.
Journal of Pharmaceutical Sciences   70 1120-1128   1981   [Refereed]

Misc

 
永島一輝, 板垣文雄, 片桐幸子, 出口芳春, 栗原順一, 渡邊真知子
日本薬学会年会要旨集(CD-ROM)   133rd ROMBUNNO.30AMG-114   2013
DEGUCHI Yoshiharu
71(3) 153-158   May 2011
丸山桂司, 宇都口直樹, 渡部多真紀, 渡辺茂和, 齋藤百枝美, 曽賀千智, 高橋和子, 下平秀夫, 出口芳春, 土屋雅勇, 江戸清人, 丸山一雄, 小佐野博史, 栗原順一, 井上圭三
日本薬学会年会要旨集   130th(4) 344   Mar 2010
佐藤武則, 黄倉崇, 高野祐輔, 山下純, 寺崎哲也, 出口芳春
薬剤学   68(Supplement) 98   Apr 2008
高野祐輔, 黄倉崇, 佐藤武則, 山下純, 寺崎哲也, 出口芳春
日本薬学会年会要旨集   128th(4) 92   Mar 2008

Books etc

 
Bioactives in Fruit: Health benefits and functional foods, First edition
Shizuo Yamada, Yuko Taki, Shingen Misaka, Takashi Okura, Yoshiharu Deguchi, Keizo umegaki, Hiroshi Watanabe, Yasuo Watanabe, Margot Skinner (Ed. by Margot Skinner and Denise Hunter) (Part:Contributor, Pharmacokinetic and pharmacodynamic interaction of functional foods with medicines.)
Wiley-Blackwell   2013   
Handbook of Biologically Active Peptides
Deguchi Y and Terasak T. (Part:Contributor, Transport of basic peptides at the blood-brain barrier)
Elsevier   2006   
Calcium Ion Modulators- The New Wave of Psychotropic Drugs (Ed. by K. Inoue and Y. Watanabe)
S. Yamada, S. Uchida, Y. Deguchi and R. Kimura (Part:Contributor, Receptor binding characteristics of nimodipine and other 1,4-dihydropyridine Ca2+ antagonists in relation to their pharmacokinetics in senescent brain)
Harwood academic publishers   1998   

Conference Activities & Talks

 
Expression and functional characterization of SLC transporters in brain microvascular endothelial cells derived from human induced pluripotent stem cells.
KUROSAWA T., Tega Y., DEGUCHI Y.
13th International Conference on Cerebral Vascular Biology (Miami)   Jun 2019   
Screening of proton-coupled organic cation antiporter substrates using hCMEC/D3 cells: an in vitro human blood-brain barrier model
KITAMURA A., DEGUCHI Y.
Oct 2018   
Analysis of gene expression profiles to the transport activity of the proton/ organic cation antiport system in hCMEC/D3 cells [Invited]
DEGUCHI Yoshiharu
Barcelone BioMed Conferences   Nov 2015   
大澤岳史, 有賀悦子, 黛芽衣子, 大野智, 久保佳子, 赤垣みゆき, 樋口慧, 黄倉崇, 出口芳春
日本緩和医療学会学術大会プログラム・抄録集   2014   
樋口慧, 北村敦, 黄倉崇, 出口芳春
日本薬学会年会要旨集(CD-ROM)   2014   
黄倉崇, 樋口慧, 出口芳春
日本薬学会年会要旨集(CD-ROM)   2014   
野原雪菜, 嘉山奨, 谷紀彦, 田畑英嗣, 北村敦, 出口芳春, 夏苅英昭, 高橋秀依
日本薬学会関東支部大会講演要旨集   15 Oct 2013   
鈴木正, 水野夏海, 福嶋彩葉, 樋口慧, 北村敦, 黄倉崇, 出口芳春
日本薬学会関東支部大会講演要旨集   15 Oct 2013   
北村敦, 樋口慧, 黄倉崇, 出口芳春
日本薬学会関東支部大会講演要旨集   15 Oct 2013   
石井雅人, 檜章子, 水野良美, 宮あずさ, 渡邉夏妃, 樋口慧, 北村敦, 黄倉崇, 出口芳春
日本薬学会関東支部大会講演要旨集   Oct 2013   
黄倉崇, 樋口慧, 出口芳春
日本薬剤学会年会講演要旨集(Web)   26 Apr 2013   
樋口慧, 黄倉崇, 出口芳春
日本薬剤学会年会講演要旨集(Web)   26 Apr 2013   
富岡直子, 道志勝, 市田公美, 森崎隆幸, 出口芳春, 細山田真
日本薬学会年会要旨集(CD-ROM)   2013   
黄倉崇, 加藤清香, 出口芳春
日本薬剤学会年会講演要旨集(Web)   25 Apr 2012   
呉春勇, 楠原洋之, 出口芳春, 杉山雄一
日本薬剤学会年会講演要旨集(Web)   25 Apr 2012   
加藤清香, 黄倉崇, 細山田真, 出口芳春
日本薬学会年会要旨集   5 Mar 2012   
黄倉崇, 加藤清香, 森本理代, 油井聡, 山下純, 寺崎哲也, 出口芳春
生体膜と薬物の相互作用シンポジウム講演要旨集   24 Nov 2011   
森本理代, 加藤清香, 黄倉崇, 加藤将夫, 森山芳則, 出口芳春
日本薬剤学会年会講演要旨集   1 May 2011   
黄倉崇, 加藤清香, COURAUD Pierre‐Oliver, 出口芳春
日本薬剤学会年会講演要旨集   1 May 2011   
黄倉崇, 加藤清香, COURAUD Pierre‐Oliver, 出口芳春
日本薬学会年会要旨集   5 Mar 2011   
森本理代, 加藤清香, 黄倉崇, 加藤将夫, 森山芳則, 帯刀章子, 出口芳春
日本薬学会年会要旨集   5 Mar 2011   
前田益孝, 林広紹, 宇野智美, 吉田顕子, 高橋暁子, 稲葉直人, 出口芳春
日本腎臓学会誌   25 May 2010   
下村慶太, 黄倉崇, 加藤清香, COURAUD Pierre‐Oliver, 出口芳春
薬剤学   20 Apr 2010   
黄倉崇, 加藤清香, COURAUD Pierre‐Oliver, 出口芳春
日本緩和医療薬学会年会プログラム・要旨集   2010   
Okura Takashi, Kato Sayaka, Deguchi Yoshiharu
Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics   2010   
KATO Sayaka, OKURA Takashi, DEGUCHI Yoshiharu
Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics   2010   
下村慶太, 黄倉崇, 加藤清香, HUMMERLUND‐UDENAES Margareta, COURAUD Pierre‐Oliver, 寺崎哲也, 出口芳春
薬剤学   30 Apr 2009   
加藤清香, 黄倉崇, 佐藤武則, 若山友彦, 大槻純男, 寺崎哲也, 出口芳春
薬剤学   30 Apr 2009   
佐藤武則, 黄倉崇, 加藤清香, 大槻純男, 寺崎哲也, 出口芳春
日本薬学会年会要旨集   5 Mar 2009   
下村慶太, 黄倉崇, 加藤清香, HAMMARLUND‐UDENAES Margareta, 寺崎哲也, 出口芳春
日本薬学会年会要旨集   5 Mar 2009   
Okura Takashi, Shimomura Keita, Kato Sayaka, Couraud Pierre-Oliver, Hammarlund-Udenaes Margareta, Terasaki Tetsuya, Deguchi Yoshiharu
Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics   2009   
Gene Expression and Transport Function of a Novel Cation Transporter PMAT in the Blood-Brain Barrier [Invited]
DEGUCHI Yoshiharu
Japan-France Joint Symposium on the Membrane Transport and Drug Targeting   16 Mar 2008   

Works

 
Blood-brain barrier transport mechanism of bFGF
1998
Analysis of brain distribution mechanism of a novel drug against Alzheimer's disease.
1999
Studies on corneal drug transport mechanism and ocular drug delivery system.
1997
Analysis of the blood-brain barrier transport mechanism of a novel mu1-selective opioid peptide.
2000
Study on the pulmonary distribution of new quinolone antibacterials.
2002

Research Grants & Projects

 
The Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(C)
Project Year: 2013 - 2015    Investigator(s): DEGUCHI, Yoshiharu
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2010 - 2012    Investigator(s): Yoshiharu DEGUCHI
Prediction of the brain distribution of drugs, based on the transport function of the human blood-brain barrier (BBB), is important for not only development of new central nervous system (CNS)-acting drugs, but also pharmacotherapy for CNS disease...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2008    Investigator(s): Yoshlharu DEGUCHI
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Yoshiharu DEGUCHI
This study was to investigate functional changes in the blood-brain barrier (BBB) and mechanism for neuron protection in the ischemic brain. Firstly, the neuroprotective effects was examined in transient brain ischemia induced by bilateral carotid...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2002 - 2003    Investigator(s): Yoshiharu DEGUCHI
The adsorptive-mediated transport system (AMTS) has been believed to be one of the most advantageous system for the delivery of the pep tides and protein to the brain. The objective in this research is to clarify the adsorptive-mediated transport ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1999 - 2000    Investigator(s): Yoshiharu DEGUCHI
The final goal of this study is to control the expression of drug efflux transporter in the blood-brain barrier (BBB) and to improve the brain transferability of the drug. There is the possibility of suppressing the efflux transporter by introduci...
Analysis of Blood-Brain Barrier Transport Mechanism of Drugs and Peptides
Project Year: 2000   
Development of drug delivery system to the brain using blood-brain barrier transport function
Project Year: 2003   
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1997 - 1998    Investigator(s): Yoshiharu DEGUCHI
There are increasing evidences that the drug efflux pump like P-glycoprotein in the blood- brain barrier (BBB) is actively extruded many drugs from brain to blood circulation, resulting in the limited distribution to the brain. The goal of this re...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C), 基盤研究(C))
Project Year: 1995 - 1996    Investigator(s): 出口 芳春, Yoshiharu DEGUCHI
Clarification of the brain distribution of centrally acting pharmaceuticals after systemic administration is important to better understanding their pharmacological effects in the central nervous system. As a rule, the drug concentration in the br...
Analysis of blood-brain barrier transport using the brain microdialysis technique
Project Year: 1995   
The Development of the Blood-Brain Barrier Transport Vector.
The development of the brain delivery system of peptide, protein and gene.
Analysis of the blood-brain barrier transport of drugs via the transporters and the receptors.