論文

査読有り
2012年6月

Causes of thrombocytopenia in chronic hepatitis C viral infection

Clinical and Applied Thrombosis/Hemostasis
  • Makoto Osada
  • Makoto Kaneko
  • Minoru Sakamoto
  • Masumi Endoh
  • Koichi Takigawa
  • Katsue Suzuki-Inoue
  • Osamu Inoue
  • Kaneo Satoh
  • Nobuyuki Enomoto
  • Yutaka Yatomi
  • Yukio Ozaki
  • 全て表示

18
3
開始ページ
272
終了ページ
280
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/1076029611429124

We retrospectively studied 89 patients with chronic hepatitis C virus (HCV) infection, including 50 chronic hepatitis (CH) cases, 18 liver cirrhosis (LC) cases, and 21 LC with hepatocellular carcinoma (LC + HCC) cases, with regard to various factors related with thrombocytopenia. The platelet count decreased with the stage advancement of liver diseases. Multiple regression analysis revealed that splenomegaly and von Willebrand factor (vWF) were explanatory variables that correlated with thrombocytopenia. Splenomegaly appears to be the most responsible factor, although there are a considerable number of thrombocytopenic cases without splenomegaly, suggesting other factors may also be responsible. The vWF level is inversely correlated with the platelet count. Soluble thrombomodulin, a marker of endothelial dysfunction, increases with the advancement of liver fibrosis. It is positively correlated with vWF and inversely with the platelet count. Our present results imply that vascular endothelial dysfunction is also involved in thrombocytopenia during chronic HCV infection. © 2012 The Author(s).

リンク情報
DOI
https://doi.org/10.1177/1076029611429124
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22327815
ID情報
  • DOI : 10.1177/1076029611429124
  • ISSN : 1076-0296
  • ISSN : 1938-2723
  • PubMed ID : 22327815
  • SCOPUS ID : 84860779117

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