豊岡利正 (Toshimasa Toyo'oka) - マイポータル

基本情報

所属: 静岡県立大学薬学部薬学科特任教授

学位: 薬学博士(東京大学)

J-GLOBAL ID: 200901054230090743
researchmap会員ID: 1000356935

外部リンク: http://w3pharm.u-shizuoka-ken.ac.jp/~analchem/

研究キーワード

研究分野

受賞

論文

134

Risk assessment of diabetes mellitus using dried saliva spot followed by ultra-performance liquid chromatography with fluorescence and mass spectrometry

Numako Masahiro, Toyo'oka Toshimasa, Noge Ichiro, Kitagawa Yutaka, Mizuno Hajime, Todoroki Kenichiro

MICROCHEMICAL JOURNAL 142 202-207 2018年11月査読有り
Sensitive and Comprehensive LC-MS/MS Analyses of Chiral Pharmaceuticals and Their Hepatic Metabolites Using Ovomucoid Column.

Todoroki K, Kudoh Y, Nakamura M, Shimizu Y, Sasaki T, Otsuki H, Wada K, Min JZ, Mizuno H, Yoshinari K, Toyo'oka T

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 34(9) 1011-1015 2018年9月査読有り
Development of Highly Sensitive Analysis Method for Histamine and Metabolites in Pregnant Women's Fingernail by UPLC-ESI-MS.

Ma Q, Uchibe A, Shi Q, Toyo'oka T, Xu CY, Min JZ

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 34(9) 1023-1029 2018年9月査読有り
A novel, simplified strategy of relative quantification N-glycan: Quantitative glycomics using electrospray ionization mass spectrometry through the stable isotopic labeling by transglycosylation reaction of mutant enzyme Endo-M-N175Q

Qing Shi, Ryugo Hashimoto, Tadamune Otsubo, Kiyoshi Ikeda, Kenichiro Todoroki, Hajime Mizuno, Dongri Jin, Toshimasa Toyo'oka, Zhe Jiang, Jun Zhe Min

Journal of Pharmaceutical and Biomedical Analysis 149 365-373 2018年2月5日査読有り
High Sensitivity and Precision High-Temperature Reversed-Phase LC Analysis of Bevacizumab for Intact Bioanalysis of Therapeutic Monoclonal Antibodies

Yamada Tomohiro, Mizuno Hajime, Min Jun Zhe, Toyo'oka Toshimasa, Todoroki Kenichiro

CHROMATOGRAPHY 39(1) 21-26 2018年査読有り
Current mass spectrometric tools for the bioanalyses of therapeutic monoclonal antibodies and antibody-drug conjugates

Kenichiro Todoroki, Tomohiro Yamada, Hajime Mizuno, Toshimasa Toyo'Oka

Analytical Sciences 34(4) 397-406 2018年査読有り
Gas-Phase Stability of Negatively Charged Organophosphate Metabolites Produced by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization

Daiki Asakawa, Hajime Mizuno, Toshimasa Toyo'oka

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 28(12) 2561-2568 2017年12月査読有り
Retention of glycopeptides analyzed using hydrophilic interaction chromatography is influenced by charge and carbon chain length of ion-pairing reagent for mobile phase

Kenichiro Furuki, Toshimasa Toyo'oka

BIOMEDICAL CHROMATOGRAPHY 31(11) 2017年11月査読有り
Simultaneous optimization of pH and binary organic composition by grid form modeling of the retention behavior in reversed-phase ultra high-performance liquid chromatography

Tsukasa Sasaki, Kenichiro Todoroki, Toshimasa Toyo'oka

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 146 251-260 2017年11月査読有り
A novel rapid analysis using mass spectrometry to evaluate downstream refolding of recombinant human insulin-like growth factor-1 (mecasermin)

Kenichiro Furuki, Toshimasa Toyo'oka, Hideto Yamaguchi

RAPID COMMUNICATIONS IN MASS SPECTROMETRY 31(15) 1267-1278 2017年8月査読有り
Relationship between dexmedetomidine dose and plasma dexmedetomidine concentration in critically ill infants: A prospective observational cohort study

Yoshihito Fujita, Koichi Inoue, Tasuku Sakamoto, Saya Yoshizawa, Maiko Tomita, Toshimasa Toyo’oka, Kazuya Sobue

Korean Journal of Anesthesiology 70(4) 426-433 2017年8月1日査読有り
Determination of thiol-to-protein ratio and drug-to-antibody ratio by in-line size exclusion chromatography with post-column reaction

Kenichiro Furuki, Toshimasa Toyo'oka

ANALYTICAL BIOCHEMISTRY 527 33-44 2017年6月査読有り
Caffeine Suppresses the Activation of Hepatic Stellate Cells cAMP-Independently by Antagonizing Adenosine Receptors

Momoka Yamaguchi, Shin-ya Saito, Ryota Nishiyama, Misuzu Nakamura, Kenichiro Todoroki, Toshimasa Toyo'oka, Tomohisa Ishikawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN 40(5) 658-664 2017年5月査読有り
Derivatization-based High-throughput Bioanalysis by LC-MS

Toshimasa Toyo'oka

ANALYTICAL SCIENCES 33(5) 555-564 2017年5月査読有り
Highly sensitive glycosylamine labelling of O-glycans using non-reductive β-elimination.

Furuki K, Toyo'oka T, Ban K

Analytical and bioanalytical chemistry 409(9) 2269-2283 2017年3月査読有り
The great importance of normalization of LC-MS data for highly-accurate non-targeted metabolomics

Hajime Mizuno, Kazuki Ueda, Yuta Kobayashi, Naohiro Tsuyama, Kenichiro Todoroki, Jun Zhe Min, Toshimasa Toyo'oka

BIOMEDICAL CHROMATOGRAPHY 31(1) 2017年1月査読有り
A rapid and sensitive detection of D-Aspartic acid in Crystallin by chiral derivatized liquid chromatography mass spectrometry

Hajime Mizuno, Yasuto Miyazaki, Keisuke Ito, Kenichiro Todoroki, Jun Zhe Min, Toshimasa Toyo'oka

JOURNAL OF CHROMATOGRAPHY A 1467 318-325 2016年10月査読有り
Diagnostic Approach to Disease Using Non-invasive Samples Based on Derivatization and LC-ESI-MS/MS

Toshimasa Toyo'oka

BIOLOGICAL & PHARMACEUTICAL BULLETIN 39(9) 1397-1411 2016年9月査読有り
Highly sensitive derivatization reagents possessing positively charged structures for the determination of oligosaccharides in glycoproteins by high-performance liquid chromatography electrospray ionization tandem mass spectrometry

Jun Zhe Min, Keisuke Nagai, Qing Shi, Wenjun Zhou, Kenichiro Todoroki, Koichi Inoue, Yong-Ill Lee, Toshimasa Toyo'oka

JOURNAL OF CHROMATOGRAPHY A 1465 79-89 2016年9月査読有り
Principal component analysis of molecularly based signals from infant formula contaminations using LC-MS and NMR in foodomics

Koichi Inoue, Chihiro Tanada, Takahiro Hosoya, Shuhei Yoshida, Takashi Akiba, Jun Zhe Min, Kenichiro Todoroki, Yutaka Yamano, Shigenori Kumazawa, Toshimasa Toyo'oka

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 96(11) 3876-3881 2016年8月査読有り

もっとみる

MISC

147

Determination of rat hepatocellular glutathione by reversed-phase liquid chromatography with fluorescence detection and cytotoxicity evaluation of environmental pollutants based on the concentration change

T Toyo'oka, J Tanabe, H Jinno

BIOMEDICAL CHROMATOGRAPHY 15(4) 240-247 2001年6月
R(-)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, a fluorescent chiral tagging reagent: sensitive resolution of chiral amines and amino acids by reversed-phase liquid chromatography

T Toyo'oka, D Jin, N Tomoi, T Oe, H Hiranuma

BIOMEDICAL CHROMATOGRAPHY 15(1) 56-67 2001年2月
Determination of Triazolam involving the Hydroxy Metabolites in Hair Shaft and Hair Root by Reversed-phase liquid chromatography with Electrospray Ionization Mass Spectrometry and Application to Human Hair Analysis. (共著)

Anal. Biochem. in press 2001年
Simultaneous Determination of Morphine and its Glucuronides in Rat Hair and in Rat Plasma by Reversed-phase Liquid Chromatography with Electrospray Ionization Mass Spectrometry. (共著)

Analyst 126(8) 1339-1345 2001年
Determination of Intracellular Glutathione in Rat Hepatocytes after Treatment of Environmental Pollutants by Capillary Electrophoresis with Laser-induced Fluorescence Detection. (共著)

Anal. Chim. Acta 433(1) 1-12 2001年
平成10年度〜平成11年度文部省科学研究基盤研究A(1)哺乳類体内に存在するD型アミノ酸の総合的研究.

研究成果報告書 1-248 2000年
レーザー蛍光検出キャピラリ電気泳動法による官能基特異的分析法の開発.

平成9〜11年度科学研究費補助金(基盤研究C)研究成果報告書 1-87 2000年
日本薬学会第120年会講演ハイライト(共著)

2000年
生体分子の分析科学2、第6部分析法の応用 4.医薬品分析(共著)

広川書店 450-471 2000年
最新機器分析学、3 蛍光分析法(共著)

南山堂 35-56 2000年
Determination of Alkylphenols in Mineral Water packed in Pet Bottles by Liquid Chromatography. (共著)

Toshimasa TOYO&rsquo, OKA, Yukari OSHIGE

Anal. Sci 16(10) 1071-1076 2000年
Detection of Triazolam and its Hydroxy Metabolites in Rat Hair by Reversed-phase liquid chromatography with Electrospray Ionizaiton Mass Spectrometry. (共著)

J. Anal. Toxicol. 24(April) 194-201 2000年
Separation of 17 DL-amino acids and chiral sequential analysis of peptides by reversed-phase liquid chromatography after labeling with R(-)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(NN-dimethylaminosu lfonyl)-2,1,3-benzoxadiazole

T Toyo'oka, N Tomoi, T Oe, T Miyahara

ANALYTICAL BIOCHEMISTRY 276(1) 48-58 1999年12月
平成10年度文部省科学研究基盤研究A(1)哺乳類体内に存在するD型アミノ酸の総合的研究.(共著)

研究実績報告書 1999年
レーザー蛍光検出キャピラリ電気泳動法による官能基特異的分析法の開発.

平成10年度科学研究費補助金(基盤研究C)研究実績報告書 1999年
薬物中毒、薬害、農薬中毒等の予防と原因解明のための毛髪診断研究.(共著)

平成10年度厚生科学研究報告書 39-69 1999年
Chiral separation by high-performance liquid chromatography of D/L-amino acids labelled with a chiral fluorescent reagent

Toshimasa Toyo'oka, Dongri Jin, Kayoko Nagakura, Sumiyo Murofushi

Biomedical Chromatography 13(2) 103-104 1999年
Development of assay system for anti-oxidants by high-performance liquid chromatography with chemiluminescence detection

Toshimasa Toyo'oka, Ayako Ogawa, Hisako Arai, Hisayuki Tanizawa

Biomedical Chromatography 13(2) 101-102 1999年
Derivatizaiton for Resolution of Chiral Compounds (chapter 6) in MODERN DERIVATIZATION METHODS FOR SEPARATION SCIENCES (共著)

John Wiley & Sons, Chichester, England. 217-289 1999年
A Novel Bi-Functional Fluorescent Probe for Hydrophobicity and Alkali Metal Ions. (共著)

Tomoyuki OE, Mitsuru MORITA, Toshimasa TOYO&rsquo, OKA

Anal. Sci. 15(10) 1021-1023 1999年

もっとみる

所属学協会

Works(作品等)

D-アミノ酸の総合的研究

1997年 - 1998年
Total Study of D-Amino Acids

1997年 - 1998年
ペプチド性医薬品の高感度特異的検出法の開発

1995年 - 1997年
Development of Sensitive and Selective Method for peptide Drugs

1995年 - 1997年
ルミネッセンスを用いる光学活性薬物の分析技術開発

1992年 - 1994年
Development of Analytical Method for chiral Drugs with Luminescence

1992年 - 1994年

豊岡利正

基本情報

研究キーワード

研究分野

受賞

論文

MISC

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

産業財産権

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