Hisaya Akiba

J-GLOBAL         Last updated: Oct 18, 2019 at 16:50
 
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Name
Hisaya Akiba
Affiliation
Juntendo University
Section
Graduate School of Medicine
Job title
Associate Professor
Degree
(BLANK)(Juntendo University)
Other affiliation
Juntendo University

Research Interests

 
 

Research Areas

 

Education

 
 
 - 
1990
Graduate School, Division of Hygienic Science, Kitasato University
 
 
 - 
1988
Faculty of Hygienic Science, Kitasato University
 

Published Papers

 
Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S
Journal of immunology (Baltimore, Md. : 1950)   199(11) 3733-3737   Dec 2017   [Refereed]
Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J
Investigative ophthalmology & visual science   57(15) 6815-6823   Dec 2016   [Refereed]
Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, Brahiti H, Ponsoye M, Fréchet M, Burgevin A, Pezet S, Sadoine J, Guilbert T, Nicco C, Akiba H, Heissmeyer V, Subramaniam A, Resnick R, Molberg Ø, Kahan A, Chiocchia G, Allanore Y
Proceedings of the National Academy of Sciences of the United States of America   113(27) E3901-10   Jul 2016   [Refereed]
Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S
Biochemical and biophysical research communications   463(4) 739-745   Aug 2015   [Refereed]
Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K
Experimental lung research   41(7) 370-382   2015   [Refereed]
Tripathi S, Chabtini L, Dakle PJ, Smith B, Akiba H, Yagita H, Guleria I
PloS one   10(4) e0123439   2015   [Refereed]
Kaneyama T, Tomiki H, Tsugane S, Inaba Y, Ichikawa M, Akiba H, Yagita H, Kim BS, Koh CS
International immunology   26(7) 369-381   Jul 2014   [Refereed]
Nozaki Y, Kitching AR, Akiba H, Yagita H, Kinoshita K, Funauchi M, Matsumura I
American journal of physiology. Renal physiology   306(10) F1210-21   May 2014   [Refereed]
Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H
Biochemical and biophysical research communications   444(2) 235-240   Feb 2014   [Refereed]
Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
Immunity   39(6) 1070-1081   Dec 2013   [Refereed]
Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H
Journal of immunology (Baltimore, Md. : 1950)   191(9) 4562-4572   Nov 2013   [Refereed]
Foks AC, Ran IA, Wasserman L, Frodermann V, Ter Borg MN, de Jager SC, van Santbrink PJ, Yagita H, Akiba H, Bot I, Kuiper J, van Puijvelde GH
Arteriosclerosis, thrombosis, and vascular biology   33(11) 2558-2565   Nov 2013   [Refereed]
Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, Najafian N
Journal of immunology (Baltimore, Md. : 1950)   191(8) 4447-4455   Oct 2013   [Refereed]
Ohyagi H, Onai N, Sato T, Yotsumoto S, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, Müller W, Kurabayashi K, Hosoi-Amaike M, Takahashi N, Hirokawa M, Matsushima K, Sawada K, Ohteki T
Immunity   39(3) 584-598   Sep 2013   [Refereed]
Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M
Cancer immunology, immunotherapy : CII   62(4) 629-637   Apr 2013   [Refereed]
Chabtini L, Mfarrej B, Mounayar M, Zhu B, Batal I, Dakle PJ, Smith BD, Boenisch O, Najafian N, Akiba H, Yagita H, Guleria I
Journal of immunology (Baltimore, Md. : 1950)   190(1) 88-96   Jan 2013   [Refereed]
Shimmura-Tomita M, Wang M, Taniguchi H, Akiba H, Yagita H, Hori J
PloS one   8(5) e63620   2013   [Refereed]
Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M
Nature immunology   13(9) 832-842   Sep 2012   [Refereed]
Makino F, Ito J, Abe Y, Harada N, Kamachi F, Yagita H, Takahashi K, Okumura K, Akiba H
American journal of respiratory cell and molecular biology   47(3) 298-305   Sep 2012   [Refereed]
Sugiyama M, Nakato G, Jinnohara T, Akiba H, Okumura K, Ohno H, Yoshida H
International immunology   24(6) 369-378   Jun 2012   [Refereed]

Misc

 
【免疫チェックポイント阻害薬:免疫学から理解する副作用】 基礎免疫からの考察
一色 琢磨, 秋葉 久弥
Keynote R・A   5(3) 109-113   Dec 2017
免疫チェックポイント分子は、活性化したT細胞に負のシグナルを伝達する補助シグナル分子である。これまでにPD-1、CTLA-4に対する中和抗体が抗がん剤として承認され、新たな免疫チェックポイント阻害薬も臨床応用に向けて開発が進められている。一方で、副作用も臨床的な問題となっているが、その機序に関しては不明な点が多い。われわれは新たな免疫チェックポイント阻害薬として期待される抗TIM-3抗体に関して、副作用が危惧される間質性肺炎への影響についてモデルマウスを用いて検討を行った。結果、抗TIM-...
TIM-4を標的にした関節炎制御
安倍 能之, 秋葉 久弥
臨床免疫・アレルギー科   66(2) 189-193   Aug 2016
【自己免疫疾患の発症における関与分子】 自己免疫疾患の発症とPD-1
臼井 嘉彦, 秋葉 久弥
臨床免疫・アレルギー科   53(5) 475-480   May 2010
CXCR5陽性follicular B helper T(TFH)細胞の生体内誘導におけるICOSの関与
秋葉 久弥
臨床免疫   45(4) 441-446   Apr 2006
【補助刺激 T細胞の活性化と補助刺激】 TIMファミリー分子
秋葉 久弥, 馬 娟
炎症と免疫   13(6) 698-704   Oct 2005
CD4T細胞の活性化にはTCRを介した抗原認識シグナルのほかに補助シグナル分子によるシグナルの伝達が必要である.この両方のシグナルがCD4T細胞に伝達されたとき,初めてCD4T細胞は抗原に反応して増殖,Th1やTh2細胞のエフェクター細胞へと分化する.生体内ではホメオスタシスを維持するべく通常これらTh1細胞,Th2細胞はバランスを保って存在するが,このバランスが何らかの原因で崩れることにより自己免疫疾患やアレルギー疾患の発症をもたらすと考えられている.TIMファミリー分子は新たに同定され...
【臨床免疫学 基礎研究の進歩と最新の臨床】 基礎編 リンパ球の活性化・機能調節とリンパ球機能分子
秋葉 久弥
日本臨床   63(増刊4 臨床免疫学(上)) 34-39   Apr 2005
OX40による免疫制御
秋葉 久弥
免疫Immunology Frontier   11(2) 81-88   Apr 2001
Amelioration of experimental atuoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody : a critical role for OX40 ligand in migration, but not development, of pathogenic T cells.(共著)
J Immunol   166 2108-2115   2001
接着分子・共刺激分子 OX40/OX40リガンドの生理的役割
秋葉 久弥
Annual Review免疫   2001 195-204   Nov 2000
Biochem Biophys Res Commun   270(3) 1041-1048   2000
CD27-mediated activation of murine NK cells.(共著)
J Immunol   164 1741-1745   2000
Blockade of CD134(OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation.(共著)
Blood   95 2434-2439   2000
CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.(共著)
J Immunol   162 7058-7066   1999
Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity.(共著)
J Immunol   162 2639-2647   1999
Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells.(共著)
J Immunol   163 1906-1913   1999
Biochem Biophys Res Commun   251(1) 131-136   1998

Conference Activities & Talks

 
Expression of TIM-4 in normal cornea and corneal grafts
A. Takeda, H. Taniguchi, T. Kunishige, H. Akiba, H. Yagita, J. Hori
The Annual Meeting of the Association for Research in Vision and Ophthalmology   29 Apr 2018   
Chitin Induced Airway Inflammation and Production of Prostaglandin E2
T. Takeshige, N. Harada, K. Matsuno, A. Ishimori, Y. Tanabe, H. Sasano, A. Nakamura, S. Harada, Y. Katsura, F. Makino, J. Ito, R. Atsuta, H. Akiba, K. Takahashi
27 Apr 2018   
Circulating levels of tenascin-C as type 2 biomarkers in the patients with asthma
M. Asaji, N. Harada, S. Harada, A. Ishimori, Y. Katsura, Y. Itoigawa, K. Matsuno, F. Makino, J. Ito, J. Ono, K. Tobino, H. Akiba, R. Atsuta, K. Izuhara, K. Takahashi
27 Apr 2018   
The effect of mepolizumab treatment in patients with severe asthma
Y. Sandhu, N. Harada, K. Matsuno, S. Harada, T. Takeshige, A. Ishimori, Y. Katsura, F. Makino, J. Ito, R. Atsuta, H. Akiba, K. Takahashi
The 22nd Congress of the Asian Pacific Society of Respirology   23 Nov 2017   
Serum tenascin-C levels in patients with asthma
N. Harada, M. Asaji, S. Harada, A. Ishimori, Y. Katsura, Y. Itoigawa, K. Matsuno, F. Makino, J. Ito, J. O., K. Tobino, H. Akiba, R. Atsuta1, K. Izuhara, K. Takahashi
The 22nd Congress of the Asian Pacific Society of Respirology   23 Nov 2017   
TWEAK and TGF-β induced chemokine production in human bronchial epithelial cells during epithelial mesenchymal transition
K. Matsuno, N. Harada, T. Takeshige, A. Ishimori, Y. Tanabe, H. Sasano, A. Nakamura, Y. Katsura, F. Makino, J. Ito, R. Atsuta, H. Akiba, K. Takahashi
The 22nd Congress of the Asian Pacific Society of Respirology   23 Nov 2017   
Takahashi Chitin induced airway inflammation and production of prostaglandin E2
T. Takeshige, N. Harada, K. Matsuno, A. Ishimori, Y. Tanabe, H. Sasano, A. Nakamura, S. Harada, Y. Katsura, F. Makino, J. Ito, R. Atsuta, H. Akiba
The 22nd Congress of the Asian Pacific Society of Respirology   23 Nov 2017   
Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts
H. Taniguchi, H. Hase, H. Akiba, H. Yagita, M. Azuma, J. Hori
The Annual Meeting of the Association for Research in Vision and Ophthalmology   7 May 2017   
OX40L blockade protects against skin and lung inflammation-driven fibrosis
M. Elhai, J. Avouac, A.-M. Hoffmann-Vold, J. Sadoine, T. Guilbert, H. Akiba, V. Heissmeyer, A. Subramaniam, R. Resnick, G. Chiocchia, Y. Allanore
Annual European Congress of Rheumatology   11 Aug 2016   
Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts
H. Taniguchi, T. Kunishige, H. Akiba, H. Yagita, R. Abe, J. Hori:
The Annual Meeting of the Association for Research in Vision and Ophthalmology   1 May 2016   
Anti-TIM-4 mAb ameliorates allergic lung inflammation
F. Kamachi, N. Harada, J. Ito, K. Takahashi, K. Okumura, S. Miyake, H. Akiba
The Multifaceted Roles of Type 2 Immunity   10 Dec 2014   
Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation
F. Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba
15th International Congress of Immunology   22 Aug 2013   
Investigation of the role of CD70 in the development of experimental autoimmune uveitis in mice
Y. Okunuki, Y. Usui, R. Matsuda, F. Kamachi, A. Umazume, S. Ueda, T. Kezuka, H. Akiba, H. Goto
The Annual Meeting of the Association for Research in Vision and Ophthalmology   5 May 2013   
Expression and function of inducible costimulator on peripheral blood CD4 T cells in patients with ocular Behcets disease: a new activity marker?
Y. Usui, M. Takeuchi, T. Kezuka, Y. Okunuki, H. Akiba, H. Goto
15th International Conference on Behcet’s disease   13 Jul 2012   
Therapeutic effect of anti-TIM-4 mAb in mouse models of arthritis
Y. Abe, F. Kamachi, T. Kawamoto, Y. Kojima, F. Makino, J. Ito, A.E.D.H. Moustapha, Y. Usui, K. Okumura, Y. Takasaki, H. Akiba
8th International Congress on Autoimmunity   9 May 2012   
Suppression of corneal graft rejection by blocking CD27/CD70
R. Motohashi, T. Hattori, Y. Usui, H. Nakagawa, H. Akiba, H. Goto
The Annual Meeting of the Association for Research in Vision and Ophthalmology   6 May 2012   
CD70-CD27 interaction regulates asthmatic response in a murine model of asthma
F. Makino, N. Harada, J. Ito, Y. Abe, F. Kamachi, K. Takahashi, K. Okumura, H. Akiba
XXII World Allergy Congress   4 Dec 2011   
Correlation between proportion of splenic Foxp3+ CD8+ T regulatory cells and corneal allograft survival
K. Wakayama, H. Taniguchi. H. Akiba, H. Yagita, M. Azuma, J. Hori
The Annual Meeting of the Association for Research in Vision and Ophthalmology   1 May 2011   
Expression of TLT-2 in corneal tissue and macrophages after corneal transplantation and association with immune privilege of corneal allografts
H. Taniguchi, H. Hase, H. Akiba, H. Yagita, M. Azuma, J. Hori
The Annual Meeting of the Association for Research in Vision and Ophthalmology   1 May 2011   
Secretion of wound-induced TGF-β1 and TGF-β2 enhance airway epithelial wound repair via HB-EGF and TGF-α
J. Ito, N. Harada, O. Nagashima, F. Makino, H. Yagita, K. Okumura, R. Atsuta, H. Akiba, K. Takahashi
European Respiratory Society Annual Congress   18 Sep 2010   

Association Memberships

 
 

Research Grants & Projects

 
Study on regulation of lymphocyte activation