論文

国際誌
2021年

Cerebrospinal Fluid Amyloid-β Oligomer Levels in Patients with Idiopathic Normal Pressure Hydrocephalus.

Journal of Alzheimer's disease : JAD
  • Kaito Kawamura
  • Masakazu Miyajima
  • Madoka Nakajima
  • Mitsuyasu Kanai
  • Yumiko Motoi
  • Shuko Nojiri
  • Chihiro Akiba
  • Ikuko Ogino
  • Hanbing Xu
  • Chihiro Kamohara
  • Shinya Yamada
  • Kostadin Karagiozov
  • Takeshi Ikeuchi
  • Akihide Kondo
  • Hajime Arai
  • 全て表示

83
1
開始ページ
179
終了ページ
190
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3233/JAD-210226

BACKGROUND: The amyloid-β oligomers, consisting of 10-20 monomers (AβO10-20), have strong neurotoxicity and are associated with cognitive impairment in Alzheimer's disease (AD). However, their role in patients with idiopathic normal pressure hydrocephalus (iNPH) is poorly understood. OBJECTIVE: We hypothesized that cerebrospinal fluid (CSF) AβO10-20 accumulates in patients with iNPH, and its clearance after CSF shunting contributes to neurological improvement. We measured CSF AβO10-20 levels before and after CSF shunting in iNPH patients evaluating their diagnostic and prognostic role. METHODS: We evaluated two iNPH cohorts: "evaluation" (cohort-1) with 32 patients and "validation" (cohort-2) with 13 patients. Comparison cohorts included: 27 neurologically healthy controls (HCs), and 16 AD, 15 Parkinson's disease (PD), and 14 progressive supranuclear palsy (PSP) patients. We assessed for all cohorts CSF AβO10-20 levels and their comprehensive clinical data. iNPH cohort-1 pre-shunting data were compared with those of comparison cohorts, using cohort-2 for validation. Next, we compared cohort-1's clinical and CSF data: 1) before and after CSF shunting, and 2) increased versus decreased AβO10-20 levels at baseline, 1 and 3 years after shunting. RESULTS: Cohort-1 had higher CSF AβO10-20 levels than the HCs, PD, and PSP cohorts. This result was validated with data from cohort-2. CSF AβO10-20 levels differentiated cohort-1 from the PD and PSP groups, with an area under receiver operating characteristic curve of 0.94. AβO10-20 levels in cohort-1 decreased after CSF shunting. Patients with AβO10-20 decrease showed better cognitive outcome than those without. CONCLUSION: AβO10-20 accumulates in patients with iNPH and is eliminated by CSF shunting. AβO10-20 can be an applicable diagnostic and prognostic biomarker.

リンク情報
DOI
https://doi.org/10.3233/JAD-210226
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34275898
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461658
ID情報
  • DOI : 10.3233/JAD-210226
  • PubMed ID : 34275898
  • PubMed Central 記事ID : PMC8461658

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