SEINO Hiroaki

J-GLOBAL         Last updated: Dec 16, 2019 at 10:37
SEINO Hiroaki
Research Organization of Information and Systems
National Institute of Genetics
Job title
Assisntant Professor

Research Areas


Academic & Professional Experience

Jan 2019
Assistant Professor, Office for Research Development, National Institute of Genetics
Apr 2007
Dec 2018
Assistant Professor, National Institute of Genetics
Mar 2007
Assistant Professor, Department of Molecular Genetics, National Institute of Genetics
Assistant Professor, Department of Molecular Genetics, National Institute of Genetics
Research Associate


Molecular Life Science, Graduate School, Division of Medical Sciences, Kyushu University

Published Papers

Hiroaki Seino, Tsutomu Kishi, Tsutomu Kishi, Hideo Nishitani, Fumiaki Yamao
Molecular and Cellular Biology   23 3497-3505   May 2003
Cell cycle events are regulated by sequential activation and inactivation of Cdk kinases. Mitotic exit is accomplished by the inactivation of mitotic Cdk kinase, which is mainly achieved by degradation of cyclins. The ubiquitin-proteasome system i...
Hiroshi Mitsuzawa, Hiroaki Seino, Fumiaki Yamao, Akira Ishihama
J Biol Chem.   276(20) 17117-17124   May 2001
The general transcription factor IID consists of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs). Here we report the isolation of two related TAF genes from the fission yeast Schizosaccharomyces pombe as multicopy suppres...
Takuma Nakajima, Michiko Kimura, Kazufumi Kuroda, Masato Tanaka, Akihiko Kikuchi, Hiroaki Seino, Fumiaki Yamao, Kinichiro Oda
Biochemical and Biophysical Research Communications   239 823-829   Oct 1997
Topoisomerase (topo) IIα is degraded via polyubiquitination during adenovirus E1A-induced apoptosis in MA1 cells, a derivative of the human epidermoid carcinoma cell line KB. Topo IIα ubiquitination activity in MA1 cells increased nearly 10-fold a...
Fumio Osaka, Hiroaki Seino, Takeshi Seno, Fumiaki Yamao, Fumiaki Yamao
Molecular and Cellular Biology   17 3388-3397   Jun 1997
A cDNA encoding a ubiquitin-conjugating enzyme designated UbcP4 in fission yeast was isolated. Disruption of its genomic gene revealed that it was essential for cell viability. In vivo depletion of the UbcP4 protein demonstrated that it was necess...
N. Hayashi, H. Seino, H. Seino, K. Irie, M. Watanabe, M. Watanabe, K. L. Clark, K. Matsumoto, T. Nishimoto
M.G.G.   253(1/2) 149-156   Dec 1996
The Saccharomyces cerevisiae temperature sensitive mutants srm1-1, mtr1-2 and prp20-1 carry alleles of a gene encoding a homolog of mammalian RCC1. In order to identify a protein interacting with RCC1, a series of suppressors of the srm1-1 mutatio...


Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous gene of Drosophila and S.cerevisiae(共著)
EMBO J.   10 1265-1273   1991
RCC1 is a nuclear protein required for coupling activation of cdc2 kinase with DNA synthesis and for start of the cell cycle.(共著)
Cold Spring Harb.Symp.Quant.Biol.   56 367-375   1992
DNA binding domain of RCC1 protein is not essential for coupling mitosis with DNA replication(共著)
J.Cell Sci.   102 394-400   1992
Loss of RCC1 leads to suppression of nuclear protein import in living cell(共著)
J.Bio.chem.   269 24542-24545   1994
Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran(共著)
J.B.   120 82-91   1996

Conference Activities & Talks

You got a Ph.D! What next? [Invited]
SEINO Hiroaki
MBSJ 2109   3 Dec 2019   
染色体ワークショップ   2004   
Ubiquitin-conjugating enzyme Ubc11 regulates DNA-damage checkpoint signaling pathway.
Seino, H.
The 32th Annual Meeting of The Molecular Biology Society of Japan   Dec 2009   

Research Grants & Projects

Regulation of Cell cycle by ubiquitin pathway