2021年1月7日
The effect of breast density on the missed lesion rate in screening digital mammography determined using an adjustable-density breast phantom tailored to Japanese women
PLOS ONE
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- 巻
- 16
- 号
- 1
- 開始ページ
- e0245060
- 終了ページ
- e0245060
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1371/journal.pone.0245060
- 出版者・発行元
- Public Library of Science (PLoS)
<sec id="sec001"><title>Objective</title>Despite the high risk of missing lesions in mammography, the missed lesion rate is yet to be clinically established. Further, no breast phantoms with adjustable breast density currently exist. We developed a novel, adjustable-density breast phantom with a composition identical to that of actual breasts, and determined the quantitative relationship between breast density and the missed lesion rate in mammography.
</sec><sec id="sec002"><title>Methods</title>An original breast phantom consisting of adipose- and fibroglandular-equivalent materials was developed, and a receiver operating characteristic (ROC) study was performed. Breast density, which is the fraction by weight of fibroglandular to total tissue, was adjusted to 25%, 50%, and 75% by arbitrarily mixing the two materials. Microcalcification, mass lesions, and spiculated lesions, each with unique characteristics, were inserted into the phantom. For the above-mentioned fibroglandular densities, 50 positive and 50 negative images for each lesion type were used as case samples for the ROC study. Five certified radiological technologists participated in lesion detection.
</sec><sec id="sec003"><title>Results</title>The mass-lesion detection rate, according to the area under the curve, decreased by 18.0% (<italic>p</italic>= 0.0001, 95% Confidence intervals [CI] = 0.1258 to 0.1822) and 37.8% (<italic>p</italic>= 0.0003, 95% CI = 0.2453 to 0.4031) for breast densities of 50% and 75%, respectively, compared to that for a 25% breast density. A similar tendency was observed with microcalcification; however, spiculated lesions did not follow this tendency.
</sec><sec id="sec004"><title>Conclusions</title>We quantified the missed lesion rate in different densities of breast tissue using a novel breast phantom, which is imperative for advancing individualized screening mammography.
</sec>
</sec><sec id="sec002"><title>Methods</title>An original breast phantom consisting of adipose- and fibroglandular-equivalent materials was developed, and a receiver operating characteristic (ROC) study was performed. Breast density, which is the fraction by weight of fibroglandular to total tissue, was adjusted to 25%, 50%, and 75% by arbitrarily mixing the two materials. Microcalcification, mass lesions, and spiculated lesions, each with unique characteristics, were inserted into the phantom. For the above-mentioned fibroglandular densities, 50 positive and 50 negative images for each lesion type were used as case samples for the ROC study. Five certified radiological technologists participated in lesion detection.
</sec><sec id="sec003"><title>Results</title>The mass-lesion detection rate, according to the area under the curve, decreased by 18.0% (<italic>p</italic>= 0.0001, 95% Confidence intervals [CI] = 0.1258 to 0.1822) and 37.8% (<italic>p</italic>= 0.0003, 95% CI = 0.2453 to 0.4031) for breast densities of 50% and 75%, respectively, compared to that for a 25% breast density. A similar tendency was observed with microcalcification; however, spiculated lesions did not follow this tendency.
</sec><sec id="sec004"><title>Conclusions</title>We quantified the missed lesion rate in different densities of breast tissue using a novel breast phantom, which is imperative for advancing individualized screening mammography.
</sec>
- リンク情報
- ID情報
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- DOI : 10.1371/journal.pone.0245060
- eISSN : 1932-6203
- PubMed ID : 33411847
- PubMed Central 記事ID : PMC7790234