1995年
Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats
Journal of Biochemistry
- ,
- ,
- ,
- 巻
- 118
- 号
- 3
- 開始ページ
- 643
- 終了ページ
- 649
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/oxfordjournals.jbchem.a124958
- 出版者・発行元
- Oxford University Press
Hepatic fibrosis/cirrhosis is a common hepatic disease characterized by the hyper-accumulation of connective tissue components, and hepatic necrosis. Chronic alcohol inges-tion, viral infection, and metabolic disorders are contributing factors and there has been no effective treatment. Hepatocyte growth factor (HGF), originally identified as a potent mitogen for mature hepatocytes, is a long-sought hepatotrophic factor for liver regeneration. Administration of human recombinant HGF into rats with hepatic fibrosis/cirrhosis caused by dimethylnitrosamine (DMN) elicited mitogenic action for hepatocytes, stimulated hepatic collagenase activity, and prevented the onset and progression of hepatic fibrosis/cirrhosis. Accumulation of fibrous tissue components in the liver due to DMN-treatment were markedly decreased in HGF-injected rats. Moreover, HGF completely abrogated death caused by severe hepatic cirrhosis and dysfunction. We postulate that HGF may prove to be an effective treatment for human liver fibrosis/cirrhosis and for chronic hepatic failure. © 1995 by the Journal of Biochemistry.
- リンク情報
- ID情報
-
- DOI : 10.1093/oxfordjournals.jbchem.a124958
- ISSN : 0021-924X
- PubMed ID : 8690730
- SCOPUS ID : 0029146465