Apr, 2017 - Mar, 2020
Elucidation of clinical significance and chemotherapy resistance mechanism of NAD(P)H:quinone oxidoreductase 1 (NQO1) expression for colorectal liver metastasis
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
- Grant number
- 17K10663
- Japan Grant Number (JGN)
- JP17K10663
- Grant amount
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- (Total)
- 4,550,000 Japanese Yen
- (Direct funding)
- 3,500,000 Japanese Yen
- (Indirect funding)
- 1,050,000 Japanese Yen
NQO1 is an antioxidant stress protein. The expression of NQO1 is enhanced under stressed environment in vivo. We studied how NQO1 expression affects response of preoperative chemotherapy and prognosis in colorectal liver metastasis. In this study, immunohistochemistry using monoclonal antibody was performed on the resected specimen of colorectal liver metastasis, and the expression of NQO1 was analyzed. The NQO1 positive group had worse overall survival than the NQO1 negative group, and the presence of NQO1 polymorphism was associated with a better response to preoperative chemotherapy. The expression pattern of NQO1 can predict the prognosis and the response of preoperative chemotherapy in patients with colorectal liver metastasis.
- Link information
- ID information
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- Grant number : 17K10663
- Japan Grant Number (JGN) : JP17K10663