論文

査読有り
2014年

Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window.

Biomed Res Int
  • Nawa Hiroyuki
  • ,
  • Sotoyama Hidekazu
  • ,
  • Iwakura Yuriko
  • ,
  • Takei Nobuyuki
  • ,
  • Namba Hisaaki

2014
開始ページ
697935
終了ページ
697935
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1155/2014/697935

Neuregulin-1 and epidermal growth factor (EGF) are implicated in the pathogenesis of schizophrenia. To test the developmental hypothesis for schizophrenia, we administered these factors to rodent pups, juveniles, and adults and characterized neurobiological and behavioral consequences. These factors were also provided from their transgenes or infused into the adult brain. Here we summarize previous results from these experiments and discuss those from neuropathological aspects. In the neonatal stage but not the juvenile and adult stages, subcutaneously injected factors penetrated the blood-brain barrier and acted on brain neurons, which later resulted in persistent behavioral and dopaminergic impairments associated with schizophrenia. Neonatally EGF-treated animals exhibited persistent hyperdopaminergic abnormalities in the nigro-pallido-striatal system while neuregulin-1 treatment resulted in dopaminergic deficits in the corticolimbic dopamine system. Effects on GABAergic and glutamatergic systems were transient or limited. Even in the adult stage, intracerebral administration and transgenic expression of these factors produced similar but not identical behavioral impairments, a

リンク情報
DOI
https://doi.org/10.1155/2014/697935
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24949465