論文

査読有り
2016年3月

Perinatal Exposure to Neuregulin-1 Results in Disinhibition of Adult Midbrain Dopaminergic Neurons: Implication in Schizophrenia Modeling.

Sci Rep.
  • Namba H
  • ,
  • Okubo T
  • ,
  • Nawa H

6
開始ページ
終了ページ
22606
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep22606.

Aberrant neuregulin-1 (NRG1) signals are suggested to associate with the<br />
neuropathophysiology of schizophrenia. Employing a mouse schizophrenia model<br />
established by neonatal neuregulin-1 challenge, we analysed postpubertal<br />
consequence of the NRG1 pretreatment for the electrophysiological property of<br />
nigral dopamine neurons. In vivo single unit recordings from anaesthetized<br />
NRG1-pretreated mice revealed increased spike bursting of nigral dopamine<br />
neurons. In slice preparations from NRG1-pretreated mice, spontaneous firing was <br />
elevated relative to controls. The relative increase in firing rates was<br />
abolished by a GABAA receptor antagonist. Whole-cell recording showed that<br />
perinatal NRG1 pretreatment diminished inhibitory miniature synaptic currents as <br />
well as GABAA receptor sensitivity. These results collectively suggest that<br />
perinatal exposure to neuregulin-1 results in the disinhibition of nigral<br />
dopamine neurons to influence their firing properties at the adult stage when the<br />
behavioral deficits are evident.

リンク情報
DOI
https://doi.org/10.1038/srep22606.
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26935991