MISC

1993年

BARORECEPTOR CONTROL OF VASOPRESSIN-PRODUCING CELLS IN STREPTOZOTOCIN-DIABETIC RATS

BRAIN RESEARCH BULLETIN
  • T AKAISHI
  • ,
  • S HOMMA

31
6
開始ページ
719
終了ページ
722
記述言語
英語
掲載種別
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Electrical activities of the vasopressin (AVP)-producing cell in the supraoptic nucleus of the streptozotocin diabetic (STZ-DM) rat were recorded extracellularly and compared with those in the control rat. Higher hematocrit (45.3 +/- 0.5%, mean +/- SE) and lower mean blood pressure (MBP) (89.5 +/- 2.1 mmHg) suggested that STZ-DM rats were hypovolemic and hypotensive. The mean discharge rates of AVP cells were 15.2 +/- 3.1 Hz (STZ-DM) (p < 0.05 vs. control) and 8.8 +/- 0.8 Hz (control), respectively. Pressor and depressor responses were caused by phenylephrine (1.5 and 2.9 mug/kg, IV) and nitroprusside (1.5 mug/kg, IV), respectively, during the recording the AVP cells. Pressor and depressor responses lineally (STZ-DM; gamma = -0.7071, control; gamma = -0.9262) decreased and increased the discharge activity of the cells in both experimental groups, respectively. The MBP-neuronal activity relationship in STZ-DM did not differ statistically from that in the control. These results suggest that cardiovascular regulation of AVP release is well retained in STZ-DM rats.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1993LB23100015&DestApp=WOS_CPL
ID情報
  • ISSN : 0361-9230
  • Web of Science ID : WOS:A1993LB23100015

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