論文

2009年8月

The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

SCIENCE
  • Ying He
  • ,
  • Christopher R. Jones
  • ,
  • Nobuhiro Fujiki
  • ,
  • Ying Xu
  • ,
  • Bin Guo
  • ,
  • Jimmy L. Holder
  • ,
  • Moritz J. Rossner
  • ,
  • Seiji Nishino
  • ,
  • Ying-Hui Fu

325
5942
開始ページ
866
終了ページ
870
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1126/science.1174443
出版者・発行元
AMER ASSOC ADVANCEMENT SCIENCE

Sleep deprivation can impair human health and performance. Habitual total sleep time and homeostatic sleep response to sleep deprivation are quantitative traits in humans. Genetic loci for these traits have been identified in model organisms, but none of these potential animal models have a corresponding human genotype and phenotype. We have identified a mutation in a transcriptional repressor (hDEC2-P385R) that is associated with a human short sleep phenotype. Activity profiles and sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice in a zeitgeber time- and sleep deprivation-dependent manner. These mice represent a model of human sleep homeostasis that provides an opportunity to probe the effect of sleep on human physical and mental health.

リンク情報
DOI
https://doi.org/10.1126/science.1174443
CiNii Articles
http://ci.nii.ac.jp/naid/80020523014
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19679812
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000269242400044&DestApp=WOS_CPL
ID情報
  • DOI : 10.1126/science.1174443
  • ISSN : 0036-8075
  • CiNii Articles ID : 80020523014
  • PubMed ID : 19679812
  • Web of Science ID : WOS:000269242400044

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