2009年8月
The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals
SCIENCE
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- 巻
- 325
- 号
- 5942
- 開始ページ
- 866
- 終了ページ
- 870
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.1174443
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
Sleep deprivation can impair human health and performance. Habitual total sleep time and homeostatic sleep response to sleep deprivation are quantitative traits in humans. Genetic loci for these traits have been identified in model organisms, but none of these potential animal models have a corresponding human genotype and phenotype. We have identified a mutation in a transcriptional repressor (hDEC2-P385R) that is associated with a human short sleep phenotype. Activity profiles and sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice in a zeitgeber time- and sleep deprivation-dependent manner. These mice represent a model of human sleep homeostasis that provides an opportunity to probe the effect of sleep on human physical and mental health.
- リンク情報
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- DOI
- https://doi.org/10.1126/science.1174443
- CiNii Articles
- http://ci.nii.ac.jp/naid/80020523014
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/19679812
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000269242400044&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1126/science.1174443
- ISSN : 0036-8075
- CiNii Articles ID : 80020523014
- PubMed ID : 19679812
- Web of Science ID : WOS:000269242400044