論文

2009年9月

Central AMPK contributes to sleep homeostasis in mice

NEUROPHARMACOLOGY
  • Sachiko Chikahisa
  • ,
  • Nobuhiro Fujiki
  • ,
  • Kazuyoshi Kitaoka
  • ,
  • Noriyuki Shimizu
  • ,
  • Hiroyoshi Sei

57
4
開始ページ
369
終了ページ
374
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neuropharm.2009.07.015
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

AMP-activated protein kinase (AMPK) is an energy-sensing molecular signal involved in glucose and lipid metabolism. The known interaction of sleep with energy metabolism led us to investigate the role of central AMPK in sleep homeostasis. Sleep deprivation (SD) for 6 h increased p-AMPK protein in the hypothalamus and also increased the mRNA level of Ca(2+)-/calmodulin (CaM)-dependent protein kinase kinase beta (CaMKK2), an activator of AMPK, and carnitine palmitoyltransferase 1 (CPT1), a downstream signaling factor of AMPK. Central injection of compound C (CC), an inhibitor of AMPK, suppressed EEG delta power during NREM sleep, while 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMPK, enhanced EEG delta power. The treatment of both CC and AICAR attenuated rebound responses of delta power in NREM sleep after SD. These results indicate that central AMPK is involved in the regulation of sleep depth and sleep homeostasis. (C) 2009 Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.neuropharm.2009.07.015
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000270020100004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neuropharm.2009.07.015
  • ISSN : 0028-3908
  • Web of Science ID : WOS:000270020100004

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