KIUCHI Kazutoshi

J-GLOBAL         Last updated: Dec 11, 2019 at 02:48
KIUCHI Kazutoshi
Gifu University
(BLANK)(Nagoya University)


Expression mechanism of GDNF gene/Intracellular signaling pathways through GDNF receptors/Search for a factor activating neprilysin and clarification of its mechanism of action

Research Areas


Academic & Professional Experience

Nagoya University, Research Assistant
Nagoya University, Lecturer
THe Institute of Physical and Chemical Research(RIKEN), Head
- Gifu University, Professor


Graduate School, Division of Medicine, Nagoya University
Applied Chemistry, Faculty of Science and Engineering, Waseda University

Published Papers

Development of electrodes with conductive polymer for stimulating nervous system.
Ito Y, Yagi T, Ohnishi Y, Kiuchi K, Uchikawa Y
Technical Report of IEICE   155 33-38   2000
Takeuchi A, Miyaishi O, Kiuchi K, Isobe K
J. Neurobiol.   45(1) 39-46   Oct 2000
Tanaka M, Ito S, Kiuchi K
Biochim. Biophys. Acta   1494(1-2) 63-74   Nov 2000
Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinalcord injury.
Satake K, Matsuyama Y, Kamiya M, Kawakami H, Iwata H, Adachi K, Kiuchi K
Neuroreport   11(17) 3877-3881   Nov 2000
Tanaka M, Ito S, Matsushita N, Mori N, Kiuchi K
Brain Res. Mol. Brain Res.   85(1-2) 91-102   Dec 2000


Shoko Shibata, Kyoji Furuta, Masahide Maeda, Masaaki Suzuki, Kentaro Oh-hashi, Kazutoshi Kiuchi, Yoko Hirata
Brain Research   1296 196-202
We show that cyclopentenone derivatives, which are synthetic analogs of cyclopentenone prostaglandins, are neuroprotective against glutamate-induced oxidative stress in HT22 cells. This effect was antagonized by a peroxisome proliferator-activated...
Junpei Norisada, Yoko Hirata, Yoko Hirata, Fumimasa Amaya, Kazutoshi Kiuchi, Kazutoshi Kiuchi, Kentaro Oh-Hashi, Kentaro Oh-Hashi
PLoS ONE   11    Jan 2016
© 2016 Norisada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ar...
Takahiro Hikiji, Junpei Norisada, Junpei Norisada, Yoko Hirata, Yoko Hirata, Kensuke Okuda, Hideko Nagasawa, Shinsuke Ishigaki, Gen Sobue, Kazutoshi Kiuchi, Kazutoshi Kiuchi, Kentaro Oh-Hashi, Kentaro Oh-Hashi
Biochemical and Biophysical Research Communications   463 881-887
© 2015 Elsevier Inc. All rights reserved. Activation of inositol-requiring enzyme 1 (IRE1) due to abnormal conditions of the endoplasmic reticulum (ER) is responsible for the cleavage of an unspliced form of X-box binding protein 1 (uXBP1), produc...
Mikiei Tanaka, Mikiei Tanaka, Hengyi Xiao, Yoko Hirata, Yoko Hirata, Kazutoshi Kiuchi, Kazutoshi Kiuchi
Brain Research Protocols   11 119-122
Glial cell line-derived neurotrophic factor (GDNF), a potent survival and trophic factor for various neuronal cells, has been measured by assaying its bioactivity based on neurite outgrowth or cell proliferation. We describe herein a sensitive and...
Akira Ishii, Kazutoshi Kiuchi, Ryoji Kobayashi, Mariko Sumi, Hiroyoshi Hidaka, Toshiharu Nagatsu
Biochemical and Biophysical Research Communications   176 1051-1056
Involvement of Ca2+ calmodulin-dependent protein kinase II ( Ca2+ CaM-kinase II) on the phosphorylation of tyrosine hydroxylase (TH, EC. in rat pheochromocytoma, PC12h cells was examined using KN-62, 1-[N,O-Bis(5-isoquinolinsulfonyl)-N-m...

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2008    Investigator(s): Kiuchi KAZUTOSHI
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1994 - 1995    Investigator(s): Kazutoshi KIUCHI
We have established a model of focal striatial injury and observed an expression of iNOS gene.A direct injection of 5-mul ethanol into rat striatum with the stereotaxic operation destroyed about one-fifth of the tissue.Expressions of genes such as...
Expression mechanisms of glial cell line-derived neurotrophic factor (GDNF) under inflammatory conditions
Grant-in-Aid for Scientific Research
Project Year: 2007 - 2008
Search for activating factors of neprilysin and analysis of their induction mechanisms
Funded Research
Project Year: 2006   
System biological analysis of gene expression in mammalian cells suffered from endoplasmic reticulum stress
Funded Research
Project Year: 2007   


Method for Detecting a Specific Portion of Organism Specimen, for Physiological Measurement of Organism Specimen, Apparatus for Detecting a Specific Portion of Organism Specimen, and a Device for Holding Optical Fiber