J-GLOBAL         Last updated: Dec 11, 2019 at 02:48
Gifu University
Faculty of Engineering
Job title
Ph.D.(Tokyo Institute of Technology)


Development of novel neuroprotective compounds effective for different neurodegenerative diseases/Oxidative and ER stress are commonly involved in the neuronal cell death in various neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Age-related decline in various neurotrophic factors which are essential for the neuronal survival and maintenance may be related to neuronal cell death. We develop newly synthesized neuroprotective compounds which protect neuronal cells from multiple stress including oxidative and ER stress, and dual-functional neuroprotective compounds which have neuroprotective and neurotrophic factor-producing activities.

Research Areas


Academic & Professional Experience

Oct 1994
Jun 2000
Frontier Research Associate, RIKEN
Jul 2000
Associate Professor, Gifu University

Published Papers

Madoka Takashima, K. Ichihara, Yoko Hirata
Food and Chemical Toxicology   132    Oct 2019
© 2019 Elsevier Ltd Propolis is a sticky dark-colored substance produced by honey bees and comprises resin, balsam, wax, essential and aromatic oils, pollen, and several other substances; it is used in food and beverages to improve health and prev...
Yoko Hirata, Takuya Iwasaki, Yukimi Makimura, Sayaka Okajima, Kentaro Oh-hashi, Hiroshi Takemori
Toxicology   418 1-10   Apr 2019
© 2019 Elsevier B.V. Double-stranded RNA-dependent protein kinase (PKR) is a component of signal transduction pathways mediating various stress signals including oxidative stress and endoplasmic reticulum (ER) stress and is suggested to be implic...
Sayaka Okajima, Akie Hamamoto, Masataka Asano, Kenta Isogawa, Hironari Ito, Shinya Kato, Yoko Hirata, Kyoji Furuta, Hiroshi Takemori
Biochemical and Biophysical Research Communications   509 209-215   Jan 2019
© 2018 Elsevier Inc. Melanin plays an important role in the protection of the skin from ultraviolet irradiation. However, excessive melanin deposition leads to hyperpigmentation and freckles, which are recognized as skin problems, and signs of agi...
Kentaro Oh-hashi, Shiori Matsumoto, Takayuki Sakai, Yoko Hirata, Kensuke Okuda, Hideko Nagasawa
Applied Biochemistry and Biotechnology      Jan 2019
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. We recently characterized the cytotoxic action of a novel phenformin derivative, 2-(2-chlorophenyl)ethylbiguanide (2-Cl-Phen), on HT-29 cells under a serum- and glucose-deprive...
Oh-Hashi K, Matsumoto S, Sakai T, Nomura Y, Okuda K, Nagasawa H, Hirata Y
Cell biology and toxicology   34(4) 279-290   Aug 2018   [Refereed]
Oh-Hashi K, Fujimura K, Norisada J, Hirata Y
Scientific reports   8(1) 12236   Aug 2018   [Refereed]
Hirata Y, Yamada C, Ito Y, Yamamoto S, Nagase H, Oh-Hashi K, Kiuchi K, Suzuki H, Sawada M, Furuta K
Neuropharmacology   135 242-252   Jun 2018   [Refereed]
Norisada J, Fujimura K, Amaya F, Kohno H, Hirata Y, Oh-Hashi K
Molecular biotechnology      Jun 2018   [Refereed]
Oh-Hashi K, Sugiura N, Amaya F, Isobe KI, Hirata Y
Molecular and cellular biochemistry   440(1-2) 65-75   Mar 2018   [Refereed]
Oh-Hashi K, Soga A, Naruse Y, Takahashi K, Kiuchi K, Hirata Y
Molecular and cellular biochemistry      Feb 2018   [Refereed]
Oh-Hashi K, Furuta E, Fujimura K, Hirata Y
Biochemistry and biophysics reports   12 40-45   Dec 2017   [Refereed]
Furuta K, Kawai Y, Mizuno Y, Hattori Y, Koyama H, Hirata Y
Bioorganic & medicinal chemistry letters   27(18) 4457-4461   Sep 2017   [Refereed]
Shibata S, Furuta K, Oh-Hashi K, Ueda H, Kiuchi K, Hirata Y
Toxicology   390 83-87   Sep 2017   [Refereed]
Furuta K, Mizuno Y, Maeda M, Koyama H, Hirata Y
Chemical & pharmaceutical bulletin   65(11) 1093-1097   2017   [Refereed]
Oh-Hashi K, Furuta E, Norisada J, Amaya F, Hirata Y, Kiuchi K
Genes to cells : devoted to molecular & cellular mechanisms   21(10) 1137-1143   Oct 2016   [Refereed]
Oh-Hashi K, Hirata Y, Kiuchi K
Cell biochemistry and function   34(7) 497-504   Oct 2016   [Refereed]
Oh-Hashi K, Irie N, Sakai T, Okuda K, Nagasawa H, Hirata Y, Kiuchi K
Molecular and cellular biochemistry   419(1-2) 29-40   Aug 2016   [Refereed]
Nomura Y, Hirata Y, Kiuchi K, Oh-Hashi K
Scientific reports   6 28016   Jun 2016   [Refereed]
Junpei Norisada, Yoko Hirata, Yoko Hirata, Fumimasa Amaya, Kazutoshi Kiuchi, Kazutoshi Kiuchi, Kentaro Oh-Hashi, Kentaro Oh-Hashi
PLoS ONE   11(1)    Jan 2016
© 2016 Norisada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ar...
Takahiro Hikiji, Junpei Norisada, Junpei Norisada, Yoko Hirata, Yoko Hirata, Kensuke Okuda, Hideko Nagasawa, Shinsuke Ishigaki, Gen Sobue, Kazutoshi Kiuchi, Kazutoshi Kiuchi, Kentaro Oh-Hashi, Kentaro Oh-Hashi
Biochemical and Biophysical Research Communications   463(4) 881-887   2015
© 2015 Elsevier Inc. All rights reserved. Activation of inositol-requiring enzyme 1 (IRE1) due to abnormal conditions of the endoplasmic reticulum (ER) is responsible for the cleavage of an unspliced form of X-box binding protein 1 (uXBP1), produc...


The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B (共著)
J. Biol. Chem.   268 24808-24812   1993
Phosphorylation and activation of p70 S6 kinase by manganese in PC12 cells (共著)
NeuroReport   9 3037-3040   1998
Manganese mimics the action of MPP+, a dopaminergic neurotoxin, in rat striatal tissue slices (共著)
Neurosci. Lett.   311 53-56   2001
Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cell(共著)
Brain Res   1021: 243-249    2004
Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brain of anorexia nervosa (共著)
J. Neural Transm.   80 145-150   1990

Books etc

Tyrosine hydroxylase : Biochemical properties and short-term regulation in vitro and in vivo
"Pharmacology of Endogeneous Neurotoxins" ed. by A. Moser, Birkhauser, Boston   1998   
The nerve growth factor family (共著)
"Growth Factors and Cytokines in Health and Disease", JPI Press Inc.   1996   
Abnormality of central monoaminergic neurons in spontaneously hypertensive rats : In vitro and in vivo(voltammetry) studies (共著)
"Brain and blood pressure control" ed. by K. Nakamura, Elsevier, Amsterdam   1986   
Elucidation of hydroxylases by calmodulin antagonists (共著)
"Calmodulin Angagonists and Cellular Physiology" eds. H.Hidaka and D.J.Hartshorne, Academic Press, New York   1985   
Receptor-mediated mutual regulation of tyrosine hydroxylase activity and the biopterin cofactor level (共著)
"Progress in Bioorganic Chemistry and Molecular Biology" eds. Yu.A. Ovchinnikov, Elsevier, Amsterdam   1984   

Association Memberships



Akt phosphorylates and regulates the orphan nuclear receptor Nur77
Characterization of NGFI-B kinase activity in rat brain
1994 - 1999
Role of caspase and Bcl-2 protein in manganese-induced apoptosis in PC12 cells

Research Grants & Projects

The role of neurotrophic factors for apoptosis induced by dopaminergic neurotoxins
Mechanisms of signaling for GDNF
Drug development for neurodegenerative diseases