2005年
Natural recombinant between equine herpesviruses 1 and 4 in the ICP4 gene
MICROBIOLOGY AND IMMUNOLOGY
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- 巻
- 49
- 号
- 2
- 開始ページ
- 167
- 終了ページ
- 179
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1348-0421.2005.tb03716.x
- 出版者・発行元
- CENTER ACADEMIC PUBL JAPAN
Equine herpesvirus 1 (EHV-1) is a pathogen causing rhinopneumonia in young horses, abortion in mares, and myeloencephalitis in adult horses. Two types, EHV-1 P and EHV-1 B, have recently been dominant among 16 electropherotypes. EHV-1 P and EHV-1 B viruses were compared by long and accurate polymerase chain reaction (LA-PCR) and restriction fragment length polymorphism (RFLP) analysis. Differences in restriction sites were found to be focused in ORF64, which encodes the infected cell protein 4 (ICP4), and downstream of the ICP4 gene. The 3'-end and downstream of ICP4 gene of EHV-1 B were found to be replaced by the corresponding region of EHV-4, indicating that EHV-1 B is a naturally occurring recombinant virus between progenitors of EHV-1 P and EHV-4. This is the first report showing a natural interspecies recombinant in alphaherpesviruses.
- リンク情報
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- DOI
- https://doi.org/10.1111/j.1348-0421.2005.tb03716.x
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/15722602
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000227142600009&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=14944356396&origin=inward
- ID情報
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- DOI : 10.1111/j.1348-0421.2005.tb03716.x
- ISSN : 0385-5600
- PubMed ID : 15722602
- Web of Science ID : WOS:000227142600009