2005年12月
Analysis of genetic polymorphism of deoxyribonuclease I in Ovambo and Turk populations using a genotyping method
BIOCHEMICAL GENETICS
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- 巻
- 43
- 号
- 11-12
- 開始ページ
- 629
- 終了ページ
- 635
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s10528-005-9120-9
- 出版者・発行元
- SPRINGER/PLENUM PUBLISHERS
Deoxyribonuclease I (DNase I) polymorphism has been used as a valuable marker in genetic and clinical investigations. Six codorminant alleles are known for DNase I, DNASE1*1, *2, *3, *4, and the recently discovered alleles *5 and *6. To detect these two new, alleles, we added a new DNase I genotyping method based on both at? allele-specific amplification and mismatched polymerase chain reaction (PCR). These methods were used to examine the distribution of DNase 1 genotypes in unrelated individuals from bloodstains of Ovambo and Turkish populations. The DNASE1*1 allele was found to be most dominant in the Ovambos. In contrast, Turks showed the highest allele frequency for DNASE1*2. This study is the first to demonstrate that there is a certain genetic heterogeneity in the worldwide distribution of DNase I polypmorphism using the genotyping method of human DNase I polymorphism with PCR.
- リンク情報
- ID情報
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- DOI : 10.1007/s10528-005-9120-9
- ISSN : 0006-2928
- Web of Science ID : WOS:000234479500007