2004年11月
Kinetic characteristics and toxic effects of benzalkonium chloride following intravascular and oral administration in rats
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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- 巻
- 811
- 号
- 1
- 開始ページ
- 53
- 終了ページ
- 58
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.jchromb.2004.03.075
- 出版者・発行元
- ELSEVIER SCIENCE BV
Kinetic characteristics and toxic effects of benzalkonium chloride (BZK) following injection via jugular vein (7V), femoral artery (FA) and oral administration (PO) were experimentally investigated using rats. The BZK concentrations in blood and tissues (lung, liver and kidney) were determined by high-performance liquid chromatography with solid phase extraction. Toxic doses of 15 and 250 mg/kg of BZK were used for intravascular (JV and FA) and PO administration, respectively. The fatal effects appeared soon after the dose in JV-rats, while delayed in FA- or PO-rats. The blood BZK concentrations and the elimination half-lives were similar between JV- and FA-rats, while the distribution of BZK in tissues was slightly different. In PO administration, the rats that aspirated BZK into their lungs had some symptoms, while the rats that did not aspirate BZK appeared to be normal. The BZK concentrations in blood and tissues were significantly higher in the aspirated PO-rats. The toxic degree of BZK was correlated with the BZK concentration in orally dosed rats. Lung and kidney had higher BZK concentrations compared to blood or liver, and they could be the target organs of BZK. (C) 2004 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jchromb.2004.03.075
- ISSN : 1570-0232
- Web of Science ID : WOS:000224397300009