2004年8月
Enterovirus-related type 1 diabetes mellitus and antibodies to glutamic acid decarboxylase in Japan
JOURNAL OF INFECTION
- 巻
- 49
- 号
- 2
- 開始ページ
- 147
- 終了ページ
- 151
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.jinf.2004.01.012
- 出版者・発行元
- W B SAUNDERS CO LTD
Objectives. In order to clarify the relationship between enteroviruses and type 1 diabetes mellitus in Japan we investigated enteroviral RNA in serum from 1 children with type 1 diabetes mellitus.
Methods. We investigated enteroviral RNA in serum from children with type 1 diabetes mellitus by using highly sensitive RT-PCR. Additionally the sequences and viral loads were determined and compared with anti-coxsackie virus antibodies and anti-glutamic acid decarboxylase (GAD) antibodies.
Results. RT-PCR for enterovirus was positive in 23 (37.7%) from 61 samples. The positivity had no disparity of age, but decreased by aging after the occurrence of type 1 diabetes mellitus. The sequences of the positives were similar as those of coxsackie B4. The viral loads revealed that there was no positive patient with high titers of anti-GAD antibodies.
Conclusion. In Japan there is some correlation with type 1 diabetes mellitus and enterovirus. The pathophysiology of type 1 diabetes mellitus seems to consist of a direct destruction by persistent coxsackie virus and the autoimmune mechanism through autoantibodies against beta-cells. (C) 2004 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
Methods. We investigated enteroviral RNA in serum from children with type 1 diabetes mellitus by using highly sensitive RT-PCR. Additionally the sequences and viral loads were determined and compared with anti-coxsackie virus antibodies and anti-glutamic acid decarboxylase (GAD) antibodies.
Results. RT-PCR for enterovirus was positive in 23 (37.7%) from 61 samples. The positivity had no disparity of age, but decreased by aging after the occurrence of type 1 diabetes mellitus. The sequences of the positives were similar as those of coxsackie B4. The viral loads revealed that there was no positive patient with high titers of anti-GAD antibodies.
Conclusion. In Japan there is some correlation with type 1 diabetes mellitus and enterovirus. The pathophysiology of type 1 diabetes mellitus seems to consist of a direct destruction by persistent coxsackie virus and the autoimmune mechanism through autoantibodies against beta-cells. (C) 2004 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.jinf.2004.01.012
- ISSN : 0163-4453
- Web of Science ID : WOS:000222756800010