論文

本文へのリンクあり
2021年12月1日

Immunogenicity of bnt162b2 mrna covid-19 vaccine in patients with cardiovascular disease

Journal of Clinical Medicine
  • Hiroyuki Naruse
  • ,
  • Hiroyasu Ito
  • ,
  • Hideo Izawa
  • ,
  • Masayoshi Sarai
  • ,
  • Junnichi Ishii
  • ,
  • Eirin Sakaguchi
  • ,
  • Reiko Murakami
  • ,
  • Tatsuya Ando
  • ,
  • Hidetsugu Fujigaki
  • ,
  • Kuniaki Saito

10
23
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/jcm10235498

Concern has been raised about the effectiveness of the coronavirus disease 2019 (COVID-19) vaccine in the population of patients with various comorbidities such as heart disease. We investigated the humoral response to the BNT162b2 mRNA COVID-19 vaccine in patients with cardiovascular disease (CVD). We measured IgG against severe acute respiratory syndrome coronavirus 2 spike receptor-binding domain (RBD−IgG) in 85 CVD patients and 179 healthcare workers (HCWs). Blood samples were collected from patients and HCWs three times: (1) before the first dose of vaccination, (2) two weeks after the first dose of vaccination, and (3) two weeks after the second dose of vaccination. Patients with CVD showed a significantly inferior serological response to the BNT162b2 mRNA COVID-19 vaccine at 14 days after the prime dose compared to HCWs (21% vs. 95%, p < 0.001). Median RBD−IgG titers of patients with CVD at 14 days after the second dose were significantly lower than those of HCWs (137.2 U/mL (80.6–200.4 U/mL) vs. 176.2 U/mL (123.9–260.0 U/mL), p < 0.001). In multivariable analyses, CVD is significantly associated with seropositivity after first vaccination and RBD−IgG titers after second vaccination. CVD patients may have a poor humoral response to the BNT162b2 mRNA COVID-19 vaccine, need to be closely monitored, and require earlier revaccination to ensure stronger immunity and protection against infection.

リンク情報
DOI
https://doi.org/10.3390/jcm10235498
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85119700684&origin=inward 本文へのリンクあり
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https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85119700684&origin=inward
ID情報
  • DOI : 10.3390/jcm10235498
  • eISSN : 2077-0383
  • SCOPUS ID : 85119700684

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