MISC

2007年1月

Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
  • Ayako Uchiyama
  • ,
  • Mutsuko Mukai
  • ,
  • Yuko Fujiwara
  • ,
  • Susumu Kobayashi
  • ,
  • Nobuyuki Kawai
  • ,
  • Hiromu Murofushi
  • ,
  • Masahiro Inoue
  • ,
  • Shigenori Enoki
  • ,
  • Yuichiro Tanaka
  • ,
  • Tamotsu Niki
  • ,
  • Tetsuyuki Kobayashi
  • ,
  • Gabor Tigyi
  • ,
  • Kimiko Murakami-Murofushi

1771
1
開始ページ
103
終了ページ
112
記述言語
英語
掲載種別
DOI
10.1016/j.bbalip.2006.10.001
出版者・発行元
ELSEVIER SCIENCE BV

Cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3-cyclic phosphate; cPA) is a naturally occurring analog of lysophosphatidic acid (LPA) with a variety of distinctly different biological activities from those of LPA. In contrast to LPA, a potent inducer of tumor cell invasion, palmitoyl-cPA inhibits FBS- and LPA-induced transcellular migration and metastasis. To prevent the conversion of cPA to LPA we synthesized cPA derivatives by stabilizing the cyclic phosphate ring; to prevent the cleavage of the fatty acid we generated alkyl ether analogs of cPA. Both sets of compounds were tested for inhibitory activity on transcellular tumor cell migration. Carba derivatives, in which the phosphate oxygen was replaced with a methylene group at either the sn-2 or the sn-3 position, showed much more potent inhibitory effects on MM1 tumor cell transcellular migration and the pulmonary metastasis of B16-FO melanoma than the natural pal-cPA. The antimetastatic effect of carba-cPA was accompanied by the inhibition of RhoA activation and was not due to inhibition of the activation of LPA receptors. (c) 2006 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 43

リンク情報
DOI
https://doi.org/10.1016/j.bbalip.2006.10.001
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000244132300011&DestApp=WOS_CPL

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